OVERWEIGHT OR OBESITY

This study is testing a weekly injection called eloralintide in adults who have painful knee osteoarthritis and are overweight or have obesity. The main goals are to see if the treatment helps reduce knee pain and leads to weight loss. About 900 participants will be in the study …

This is an early-stage study to check the safety and basic effects of a new drug called BGM1812 in Chinese adults. It will involve 60 healthy and overweight participants who will receive injections of the drug or a placebo. Researchers will monitor for side effects and see how th…

This is the first study in people to test a new injectable drug called KN069. It aims to check if the drug is safe and how it affects the body in 36 Chinese men who are overweight or have obesity. Researchers will also measure early signs of its effect on body weight and waist si…

This study is testing if adding the weight-loss medication tirzepatide to an existing psoriasis treatment (ixekizumab) works better for people who have both conditions. It will involve about 200 adults with moderate-to-severe plaque psoriasis who are also overweight or have obesi…

This study is testing a new injectable medication called olatorepatide for weight management in people who are overweight or have obesity but do not have diabetes. Researchers will compare the drug to a placebo (inactive substance) in about 120 participants to see how safe it is,…

This study is testing a once-daily pill called orforglipron to see if it can help lower high blood pressure and reduce body weight. It will involve about 487 adults who have both hypertension and are overweight or have obesity. Participants will be randomly assigned to receive ei…

This study is testing if adding a supervised weight loss program to standard back pain therapy works better for pain relief. It will involve 252 overweight or obese adults with long-term low back pain across Belgium and Switzerland. Participants will be randomly assigned to recei…

This study is testing a weight loss program designed for taxi and ride-share drivers in New York City. It will compare four different support methods—like personal counseling, text messages, and weekly calls—to see which combination works best to help drivers lose at least 5% of …

This Yale University study is testing whether people with overweight or obesity can learn to control their brain's response to food images using real-time feedback during MRI scans. Researchers want to see if this 'neurofeedback' training helps reduce food cravings and improves e…

This early-stage study aims to test two different versions of an experimental tablet called HRS9531 for managing overweight and obesity. It will involve about 168 overweight or obese men to see how their bodies process the new tablet version compared to the old one and to check f…

This study is testing if a medication called semaglutide, which is approved for weight loss, can help people with both obesity and atrial fibrillation (AFib). Researchers want to see if losing weight with this drug can reduce how often AFib occurs and its severity when used along…

This study is testing if a 4-month, online strength training program is practical and helpful for Black women at risk for heart disease and diabetes. It will enroll 36 women who do not currently do regular strength training. The main goal is to see if the program is easy to follo…

This is the first human study of a new oral medication called MWN109 tablets, designed for weight management. Researchers will test the drug's safety, how the body processes it, and what side effects occur in 60 healthy adults with overweight or obesity. The study will start with…

This study is testing whether adding the weight-loss medication tirzepatide to the standard arthritis drug ixekizumab helps people with psoriatic arthritis who are also overweight or obese. About 200 adults who have been on ixekizumab for about 3 months will take tirzepatide for …

This is an early-stage study to check the safety and side effects of a new drug called LY4064912, which is being developed for weight management. It will involve 144 healthy and overweight participants who will receive the drug as an injection under the skin or through an IV. Res…

This study is testing if the diabetes medication metformin can help control mild memory problems in older adults who are overweight or obese. Researchers will enroll 54 participants aged 60-75 and randomly assign them to receive either metformin plus lifestyle advice or lifestyle…

This study is for people who have already completed a year-long trial of the GZR18 weight loss injection. It aims to see if continuing the treatment with injections every four weeks (instead of every two) for another 24 weeks is safe and effective at helping people maintain or fu…

This early-stage study is testing a new injection called BGM1812 in healthy adults who range from normal weight to obese. Researchers want to understand how the body processes the drug, check its safety, and see if it affects body weight. The study will involve 60 participants re…

This study is testing a special online lifestyle program for young women who are planning to become pregnant. The goal is to see if improving a mother's health before and during pregnancy can lower the risk of obesity and diabetes for both her and her baby. Researchers will compa…

This study aims to understand the effects of a free, park-based afterschool program on teens' health and well-being. Researchers will analyze existing data from about 1,000 participants, aged 12-17, in Miami-Dade County's 'Fit2Lead' program. The program offers academic help, spor…

This early research study aims to understand if changing people's automatic, gut-feeling attitudes toward physical activity can help them exercise more consistently. The study will involve 120 inactive adults who are overweight or obese, using smartphone prompts and Fitbit tracke…