OVERWEIGHT OR OBESITY

This study tests if a weight loss program combined with a walking exercise plan helps people with peripheral artery disease (PAD) and overweight maintain or improve their walking ability better than walking exercise alone. About 212 adults with PAD and a BMI over 25 will take par…

This study tests whether a weight loss injection (GZR18) given once every 4 weeks can safely help people continue losing weight. It includes 500 adults who already completed a year of treatment with the same drug. Participants will receive the injection for 24 weeks while maintai…

This study looks at whether adding tirzepatide (a weight-loss drug) to the usual psoriatic arthritis treatment ixekizumab helps people with active psoriatic arthritis who are also overweight or obese. About 200 adults will take both drugs for up to 12 months. The goal is to see i…

This early-stage study tests a new drug called KN069 in 36 Chinese men who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers will monitor weight, waist size…

This early-stage study tests an experimental oral drug, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to prove weight loss yet. Participants will receive either the drug o…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AF) in overweight or obese adults. About 200 people aged 18-75 with AF and a BMI of 30 or higher will receive semaglutide alongside standard AF care. The goal is to see …

This study tests a new drug called olatorepatide in 120 adults who are overweight or obese but do not have diabetes. The drug aims to help with weight loss by targeting hormones that control appetite. Researchers will check how safe the drug is, how the body processes it, and how…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a program that includes counseling, text messages, phone support, and self-monitoring tools. About 1,785 drivers in New York City will take part. The goal is to find the most effective and…

This study tests whether metformin, a common diabetes medicine, can improve memory and thinking in overweight or obese older adults with mild cognitive impairment (MCI). Researchers will give metformin or a placebo to 54 people aged 60-75 for 26 weeks. They will use brain scans a…

This study looks at whether adding tirzepatide (a weight-loss medication) to ixekizumab (a psoriasis treatment) helps adults with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 participants will receive both drugs for up to 12 months. The main goa…

This early-phase study tests an experimental drug called BGM1812 in 60 overweight or obese but otherwise healthy adults. Participants receive either the drug or a placebo as a shot under the skin. The main goal is to check safety and how the body processes the drug, while also me…

This study tests a once-daily pill called orforglipron to see if it can lower blood pressure in people who have both high blood pressure and obesity or overweight. About 487 adults will take either the study drug or a placebo. The goal is to manage blood pressure and weight, but …

This early-stage study tests a new medicine called SYH9017 in 66 Chinese adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it after one or multiple doses. Participants receive either the drug or a placebo, and researchers…

This early-stage study tests a new formulation of the drug HRS9531 in healthy men who are overweight or obese. The goal is to compare how the body handles the new versus the old version, and to check for side effects. About 168 participants will take a single dose of the drug, an…

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. About 360 women will either join the online program or receive standard health …

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using real-time neurofeedback. Participants will undergo brain scans while practicing techniques to reduce craving-related brain activity. The…

This early-stage study tests whether MWN109 tablets are safe in healthy adults who are overweight or have obesity. About 60 participants will receive either the drug or a placebo to check for side effects and how the body processes the medication. The goal is to gather safety dat…

This early-stage study tests a new drug called LY4064912 in healthy volunteers and people with overweight or obesity. The main goal is to see if the drug is safe and what side effects it may cause. Researchers will also measure how the body processes the drug and track any change…

This study looks at whether a whey protein-enriched milk fat globule membrane supplement can improve heart and brain health after a high-fat meal. Sixteen postmenopausal women with overweight and moderate heart disease risk will drink either the supplement or a placebo. Researche…

This study tests whether adding a weight loss program (diet, exercise, and behavior changes) to standard back pain treatment helps overweight or obese people with chronic low back pain. About 252 adults will be split into two groups: one gets standard care, the other gets standar…

This early-stage study is testing an investigational drug called BGM1812 in healthy and non-diabetic overweight or obese Chinese adults. The main goal is to check the drug's safety and how the body processes it. Participants will receive either the drug or a placebo by injection,…

This phase 3 study tests a once-weekly injection called eloralintide in 900 adults who have osteoarthritis of the knee with pain and are overweight or obese. The goal is to see if the drug reduces knee pain and body weight over about 75 weeks. Participants will be randomly assign…

This study looks at how a park-based afterschool program affects the mental health, resilience, physical fitness, and violence prevention of 1000 teens aged 12-17 in Miami-Dade County. Researchers will measure changes in weight, blood pressure, fitness, anxiety, depression, and o…

This study looks at whether changing people's hidden feelings about exercise can help them be more active. Researchers will work with 120 overweight or obese adults who currently exercise less than 60 minutes per week. Participants will use a smartphone app and wear a Fitbit to t…

This study tests whether a remotely delivered resistance training program is practical and helpful for Black women aged 30-64 who are overweight, have prediabetes/diabetes, or high blood pressure. Participants will do strength training at home using their own equipment or bodywei…