OVERWEIGHT OR OBESITY

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, for weight loss in adults with overweight or obesity. About 872 participants will receive either the drugs or a placebo injection. The main goal is to see how much weight they lose over…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This early-stage study tests a new daily pill, RO7795081, in 30 healthy Chinese adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body handles it. Participants will receive either the drug or a placebo, and researchers will monitor…

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This early-stage trial tests a new drug called SYH9017 in 66 Chinese adults who are overweight or obese. The main goal is to check the drug's safety and how the body processes it after single and multiple doses. Participants will receive either the drug or a placebo, and research…

This Phase 3 study tests whether switching to a once-monthly injection of GZR18 can help 500 overweight or obese adults maintain weight loss for an additional 24 weeks. All participants previously completed a year of biweekly GZR18 treatment. The study measures changes in body we…

This study tests whether metformin, a diabetes drug, can improve memory and thinking in overweight adults aged 60-75 with mild cognitive impairment. Half of the 54 participants will take metformin daily for 26 weeks, while the other half will receive lifestyle advice only. Resear…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a combination of counseling, text messages, phone support, and self-monitoring tools. Researchers will enroll about 1,785 drivers in New York City to find out which parts of the program wo…

This early-stage study tests two versions of an experimental tablet called HRS9531 in people who are overweight or obese. The main goals are to compare how the body absorbs each version and to check for side effects. About 168 men aged 18-55 with a BMI between 24 and 35 will part…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AFib) in people who are overweight or have obesity. About 200 adults aged 18-75 with AFib and a BMI of 30 or higher will receive semaglutide plus standard AFib care. Res…

This early-stage trial is testing a new drug called BGM1812, given as an injection under the skin, to see if it is safe and how it works in the body. The study involves 60 healthy adults who are overweight or obese. Researchers will measure weight changes and monitor for any side…

This early-stage trial tests a new drug called KN069 in 36 Chinese men who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. Researchers will also look at weight and waist changes over time.

This study tests an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) designed for young women aged 18-39 with overweight or obesity who may become pregnant within two years. Participants will either join online group classes for 12 months or receive sta…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether the Thrive AI Health app can help adults with type 2 diabetes or overweight improve their daily habits like diet, exercise, and sleep. About 20 participants will either use the app or not, and researchers will compare changes over time. The app uses artif…

This study looks at whether adding a special whey protein supplement to a high-fat meal can improve markers of heart and brain health in postmenopausal women who are overweight and at moderate risk for heart disease. Sixteen women will each try the supplement and a placebo on sep…

This early-stage study is testing an experimental drug called LY4064912 in 144 healthy volunteers and people with overweight or obesity. The main goal is to check safety and how the body handles the drug, not yet to prove it works for weight loss. Participants will receive either…

This early-stage study tests a new drug called BGM1812 in 60 healthy or overweight/obese Chinese adults who do not have diabetes. The main goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo by injection, and researc…

This study tests whether people with overweight or obesity and high food cravings can learn to change their brain's response to food cues using real-time neurofeedback. Participants will try to control a thermometer-like display reflecting their brain activity while viewing food …

This early-stage study tests a new tablet called MWN109 in healthy adults who are overweight or have obesity. The main goal is to check if the drug is safe and how the body processes it. About 60 participants will receive either the drug or a placebo, and researchers will monitor…

This study tests whether adding a behavioral weight reduction program (diet, exercise, and behavior changes) to standard pain education and exercise therapy can reduce chronic low back pain in overweight or obese adults. Researchers will compare the combined approach against pain…

This study tests whether a smartphone app that sets daily exercise goals and helps you plan around barriers can change your automatic feelings about physical activity. Researchers will enroll 120 inactive adults who are overweight or obese. Participants wear a Fitbit and answer q…

This study examines how a park-based afterschool program called Fit2Lead affects the mental health, resilience, physical fitness, and violence prevention of teens aged 12-17 in Miami-Dade County. Researchers will analyze data from 1,000 participants to see changes in weight, bloo…