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Weight-Loss drug added to arthritis therapy shows promise in new trial

NCT ID NCT06864026

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 2 times

Summary

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this combination improves physical function and leads to significant weight loss.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2025

Expected to finish

Nov 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a diagnosis of active psoriatic arthritis (PsA) as defined by a rheumatologist or other healthcare professional (HCP) experienced in treating PsA. * Body Mass Index (BMI) of 30 kilograms per meter squared (kg/m²) or greater (obesity) or 27 kg/m2 to \<30 kg/m² (overweight) in the presence of at least 1 weight-related comorbid condition (hypertension, dyslipidemia, type 2 diabetes, obstructive sleep apnea, or cardiovascular disease). * Who have been treated with ixekizumab for approximately 3 months (±1 month) prior to decision to add tirzepatide. * Must be able to initiate tirzepatide (Day 0) within 30 days of treatment decision (baseline or screening). Exclusion Criteria: * Have currently received ixekizumab for more than 4 months or less than 2 months. * Had any exposure to tirzepatide or other glucagon-like peptide-1 (GLP-1) receptor agonist (for example, dulaglutide, liraglutide, or semaglutide). * Are currently enrolled in any other clinical study. * Have a known hypersensitivity to any component of tirzepatide. * Have a personal or family history of medullary thyroid cancer. * Have multiple endocrine neoplasia type 2. * Have type 1 diabetes mellitus. * Have a history of chronic or acute pancreatitis at any time before screening. * Have a history of proliferative diabetic retinopathy, diabetic maculopathy, or nonproliferative diabetic retinopathy that requires acute treatment. * Have a history of ketoacidosis or hyperosmolar state/coma. * Have a history of severe hypoglycemia unawareness within the 6 months before screening. * Have a history of severe gastrointestinal complications, including gastroparesis, gastroesophageal reflux disease, dyspepsia, chronic nausea/vomiting.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight or obesity Psoriatic arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    9 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale

    RECRUITING

    Avondale, Arizona, 85392, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler

    RECRUITING

    Chandler, Arizona, 85225, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff

    ACTIVE_NOT_RECRUITING

    Flagstaff, Arizona, 86001, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert

    COMPLETED

    Gilbert, Arizona, 85297, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale

    ACTIVE_NOT_RECRUITING

    Glendale, Arizona, 85306, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa

    ACTIVE_NOT_RECRUITING

    Mesa, Arizona, 85210, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV

    RECRUITING

    Phoenix, Arizona, 85032, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City

    ACTIVE_NOT_RECRUITING

    Sun City, Arizona, 85351, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson

    ACTIVE_NOT_RECRUITING

    Tucson, Arizona, 85704, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast

    RECRUITING

    Tucson, Arizona, 85748, United States

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Fort Worth

    ACTIVE_NOT_RECRUITING

    Fort Worth, Texas, 76109, United States

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving

    ACTIVE_NOT_RECRUITING

    Irving, Texas, 75039, United States

  • AARA Clinical Research - Murfreesboro Medical Clinic

    ACTIVE_NOT_RECRUITING

    Murfreesboro, Tennessee, 37128, United States

  • Accurate Clinical Research, Inc

    COMPLETED

    Lake Charles, Louisiana, 70605, United States

  • Accurate Clinical Research, Inc

    RECRUITING

    Houston, Texas, 77089, United States

  • Advanced Rheumatology of Houston - Woodlands

    ACTIVE_NOT_RECRUITING

    The Woodlands, Texas, 77382, United States

  • Arnold Arthritis & Rheumatology

    ACTIVE_NOT_RECRUITING

    Skokie, Illinois, 60076, United States

  • Arthritis Northwest, PLLC

    ACTIVE_NOT_RECRUITING

    Spokane Valley, Washington, 99216, United States

  • Atlanta Research Center for Rheumatology

    ACTIVE_NOT_RECRUITING

    Marietta, Georgia, 30060, United States

  • Biopharma Informatic, LLC

    ACTIVE_NOT_RECRUITING

    Katy, Texas, 77494, United States

  • CMRC Headlands, LLC

    RECRUITING

    San Juan, 00918, Puerto Rico

  • CZ Rheumatology

    ACTIVE_NOT_RECRUITING

    Miami Beach, Florida, 33140, United States

  • Clinical Research Institute of Michigan, LLC

    ACTIVE_NOT_RECRUITING

    Saint Clair Shores, Michigan, 48081, United States

  • DM Clinical Research - TRA

    RECRUITING

    Tomball, Texas, 77375, United States

  • Essential Medical Research

    ACTIVE_NOT_RECRUITING

    Tulsa, Oklahoma, 74137, United States

  • Great Lakes Clinical Trials - Ravenswood

    ACTIVE_NOT_RECRUITING

    Chicago, Illinois, 60640, United States

  • Greater Chicago Specialty Physicians

    ACTIVE_NOT_RECRUITING

    Schaumburg, Illinois, 60195, United States

  • International Center for Research

    COMPLETED

    Tampa, Florida, 33614, United States

  • Klein & Associates, M.D., P.A.

    ACTIVE_NOT_RECRUITING

    Cumberland, Maryland, 21502, United States

  • Klein & Associates, M.D., P.A.

    ACTIVE_NOT_RECRUITING

    Hagerstown, Maryland, 21740, United States

  • Lake Cumberland Rheumatology

    ACTIVE_NOT_RECRUITING

    New Albany, Indiana, 47150, United States

  • Life Clinical Trials

    ACTIVE_NOT_RECRUITING

    Margate, Florida, 33063, United States

  • Logan Health Rheumatology

    ACTIVE_NOT_RECRUITING

    Kalispell, Montana, 59901, United States

  • Medvin Clinical Research - Apple Valley

    ACTIVE_NOT_RECRUITING

    Apple Valley, California, 92307, United States

  • Medvin Clinical Research - Covina

    COMPLETED

    Covina, California, 91722, United States

  • Medvin Clinical Research - Riverside

    ACTIVE_NOT_RECRUITING

    Riverside, California, 92508, United States

  • Medvin Clinical Research - Temecula

    ACTIVE_NOT_RECRUITING

    Temecula, California, 92592, United States

  • Medvin Clinical Research - Tujunga

    RECRUITING

    Tujunga, California, 91042, United States

  • Medvin Clinical Research - Whittier

    ACTIVE_NOT_RECRUITING

    Whittier, California, 90602, United States

  • Newport Huntington Medical Group

    ACTIVE_NOT_RECRUITING

    Huntington Beach, California, 92648, United States

  • Onsite Clinical Solutions, LLC - Brenner Ave

    ACTIVE_NOT_RECRUITING

    Salisbury, North Carolina, 28144, United States

  • Paramount Medical Research & Consulting, LLC

    ACTIVE_NOT_RECRUITING

    Middleburg Heights, Ohio, 44130, United States

  • Precision Comprehensive Clinical Research Solutions - Colleyville

    RECRUITING

    Colleyville, Texas, 76034, United States

  • Providence Saint John's Medical Foundation

    ACTIVE_NOT_RECRUITING

    Santa Monica, California, 90404, United States

  • Purushotham & Akther Kotha MD, Inc

    ACTIVE_NOT_RECRUITING

    La Mesa, California, 91942, United States

  • Research Physicians Network, LLC

    ACTIVE_NOT_RECRUITING

    Houston, Texas, 77089, United States

  • Reuviva Research Center

    COMPLETED

    Guaynabo, 00968, Puerto Rico

  • Rheumatology Center of San Diego

    ACTIVE_NOT_RECRUITING

    San Diego, California, 92128, United States

  • Satilla Rheumatology & Internal Medicine

    ACTIVE_NOT_RECRUITING

    Waycross, Georgia, 31501, United States

  • Seattle Rheumatology Associates PLLC

    ACTIVE_NOT_RECRUITING

    Seattle, Washington, 98104, United States

  • University of Rochester Medical Center

    ACTIVE_NOT_RECRUITING

    Rochester, New York, 14642, United States

  • Vida Clinical Research

    ACTIVE_NOT_RECRUITING

    Kissimmee, Florida, 34741, United States

  • Vitalia Medical Research

    ACTIVE_NOT_RECRUITING

    Palm Beach Gardens, Florida, 33410, United States

  • West Tennessee Research Institute

    ACTIVE_NOT_RECRUITING

    Jackson, Tennessee, 38305, United States

  • Willow Rheumatology and Wellness PLLC

    ACTIVE_NOT_RECRUITING

    Willowbrook, Illinois, 60527, United States

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