PSORIATIC ARTHRITIS

This study is testing two investigational drugs, risankizumab and lutikizumab, to see how well they control the symptoms of active psoriatic arthritis. About 120 adults who have not gotten enough relief from other treatments will receive one drug, the other, or both together. Res…

This study is testing if giving the arthritis drug bimekizumab through an IV (into a vein) works as well as the standard injection under the skin. It will involve about 392 adults with active psoriatic arthritis or axial spondyloarthritis. The main goal is to see if the drug leve…

This study follows 1,200 people with psoriatic arthritis across 15 countries for two years to see how long they stay on different advanced treatments in real-world settings. It compares the drug risankizumab against other available therapies to understand which treatments patient…

This study is testing an investigational drug called SPY002-072 to see if it can reduce disease activity in adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. It will compare the drug to a placebo in about 285 particip…

This study is testing the safety and effects of the immunotherapy drug nivolumab in people who have both advanced cancer and an autoimmune disease like lupus, rheumatoid arthritis, or Crohn's disease. It will enroll 300 adults to see if the drug can help control their cancer whil…

This study is testing a new injectable drug called picankibart for people with active psoriatic arthritis, a condition that causes joint pain, swelling, and skin plaques. Over 200 participants will receive either the drug or a placebo injection to see if it safely reduces joint s…

This study is testing a new oral medication called zasocitinib for people with active psoriatic arthritis, a condition that causes joint pain and skin plaques. The main goal is to see if the drug is better than a placebo at reducing joint swelling and tenderness and improving ski…

This study aims to help people with psoriatic arthritis who didn't get enough relief from their first biologic medication. Researchers want to know if switching to a different type of drug (guselkumab) works better than switching to another similar drug (golimumab). The trial wil…

This study is testing whether a new oral medication called zasocitinib can help control the joint pain, swelling, and skin symptoms of psoriatic arthritis. It will involve about 1,100 adults who have active disease but have not yet tried advanced biologic injections. Participants…

This study is testing whether adding the weight-loss medication tirzepatide to the standard arthritis drug ixekizumab helps people with psoriatic arthritis who are also overweight or obese. About 200 adults who have been on ixekizumab for about 3 months will take tirzepatide for …

This study is testing whether taking capsules containing processed stool from a healthy donor can help people newly diagnosed with certain inflammatory diseases like rheumatoid arthritis, Crohn's disease, or ulcerative colitis. About 200 participants will receive either these spe…

This study aims to see if adding two questions about morning stiffness and back pain, along with pictures, to an existing screening questionnaire helps doctors identify psoriatic arthritis in adults with moderate-to-severe plaque psoriasis. About 500 participants in Canada will f…

This study is testing whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. The coordinator will work with 520 patients aged 40-75 to better manage cholesterol, blood pressure, weight, and other heart health…

This study is testing whether an online wellness program can help people with conditions like rheumatoid arthritis and lupus feel less tired and improve their quality of life. Researchers will enroll 200 participants to try a 6-month online course focused on diet, gentle exercise…

This study aims to understand what causes painful Achilles tendons in people with psoriatic arthritis. Researchers will take small tissue samples from 30 patients' painful tendons to look for specific immune cells and inflammation markers. The goal is to learn more about the dise…

This study is creating a large collection of health information and biological samples from people with various rheumatic diseases, like rheumatoid arthritis and lupus. The goal is to help scientists compare different diseases to learn more about what causes them and how they pro…

This study aims to measure how much of the medication bimekizumab (Bimzelx®) passes into breast milk. It will enroll 20 breastfeeding mothers who are already using this drug to treat conditions like psoriasis or arthritis. Researchers will collect breast milk samples over several…

This study is testing an educational tool designed to help melanoma patients who also have autoimmune diseases (like rheumatoid arthritis or Crohn's disease) understand their treatment options with immune checkpoint inhibitor drugs. Researchers want to see if the tool is easy to …

This study aims to understand how the medication bimekizumab affects specific genes in the skin of people with moderate to severe plaque psoriasis. It will involve about 90 participants, some of whom also have psoriatic arthritis. Researchers will take small skin samples to measu…