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New drug tulisokibart aims to ease psoriatic arthritis pain

NCT ID NCT07486960

Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 15, 2026 · Updated 8 times

Summary

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain and skin plaques. Researchers will compare different doses of the drug to a placebo in 140 adults to see if it improves symptoms like joint tenderness and swelling. The main goal is to check if at least one dose works better than a placebo after 16 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tulisokibart (also called MK-7240 or PRA023)
What this could lead to
If it works, this could point toward a new treatment option for people with psoriatic arthritis who haven't responded well to other therapies.
What could go wrong
This is an early phase 2 trial with only 140 participants, so results may not apply to everyone. The drug may not work better than a placebo, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 140 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Jan 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Has a clinical diagnosis of PsA and fulfillment of the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria at Screening, with symptom onset ≥6 months before Screening. * Has a diagnosis of active plaque psoriasis or documented history of plaque psoriasis. * Has history of biologic disease-modifying antirheumatic drug (bDMARD)-naïve or bDMARD-inadequate response/intolerant. Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has any arthritis with onset before age 17 years or current diagnosis of inflammatory joint disease other than PsA (such as, but not limited to, rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, myositis, etc), or any other conditions that may, in the judgment of the investigator, interfere with the assessment of PsA. * Has a skin condition diagnosis, other than psoriasis that may, in the judgment of the investigator, interfere with the assessment of psoriasis. * Has a history of cancer (except fully treated nonmelanoma skin cancers or cervical carcinoma in situ after complete surgical removal) and is disease free for \<5 years before Randomization. * Has any active infection. * Has known allergies, hypersensitivity, or intolerance to tulisokibart of its excipients.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psoriatic arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    48 sites in 8 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Altoona Center for Clinical Research ( Site 5110)

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Arizona Arthritis & Rheumatology Associates, P.C. ( Site 5117)

    RECRUITING

    Sun City, Arizona, 85351, United States

  • Arizona Arthritis & Rheumatology Associates, P.C. - Tucson ( Site 5120)

    RECRUITING

    Tucson, Arizona, 85704-1140, United States

  • Arthritis and Rheumatic Disease Specialties ( Site 5105)

    RECRUITING

    Aventura, Florida, 33180, United States

  • Arthritis and Rheumatism Associates - Rockville ( Site 5127)

    RECRUITING

    Rockville, Maryland, 20850, United States

  • Articularis Healthcare Group dba: Low Country Rheumatology ( Site 5128)

    RECRUITING

    Summerville, South Carolina, 29486, United States

  • Bradfordhill ( Site 8212)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • CECIM ( Site 8205)

    RECRUITING

    Santiago, Region M. de Santiago, 8331143, Chile

  • CHUS - Hospital Clinico Universitario ( Site 7102)

    RECRUITING

    Santiago de Compostela, La Coruna, 15706, Spain

  • Centre Rhumatologie De L'Est ( Site 5201)

    RECRUITING

    Rimouski, Quebec, G5L 8W1, Canada

  • Centre de Recherche Musculo-Squelettique ( Site 5202)

    RECRUITING

    Trois-Rivières, Quebec, G9A 3Y2, Canada

  • Centro Internacional de Estudios Clinicos (CIEC) ( Site 8201)

    RECRUITING

    Santiago, Region M. de Santiago, 8420383, Chile

  • Centro de Estudios GyC ( Site 8206)

    RECRUITING

    Santiago, Region M. de Santiago, 7500504, Chile

  • Centro de investigacion en reumatologia y especialidades medicas SAS (CIREEM SAS) ( Site 8306)

    RECRUITING

    Bogota, Cundinamarca, 110221, Colombia

  • Clinica Dermacross ( Site 8200)

    RECRUITING

    Santiago, Region M. de Santiago, 7640881, Chile

  • Clinica de la Costa S.A.S. ( Site 8301)

    RECRUITING

    Barranquilla, Atlántico, 080020, Colombia

  • Cohen Medical Centers ( Site 5111)

    RECRUITING

    Thousand Oaks, California, 91360, United States

  • Edelweiss Medics ( Site 7409)

    RECRUITING

    Kyiv, Kyivska Oblast, 02002, Ukraine

  • Enroll SpA ( Site 8203)

    RECRUITING

    Santiago, Region M. de Santiago, 7500587, Chile

  • Fundación Valle del Lili ( Site 8302)

    RECRUITING

    Cali, Valle del Cauca Department, 760032, Colombia

  • Greater Houston Rheumatology ( Site 5103)

    RECRUITING

    Houston, Texas, 77095, United States

  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg G ( Site 6404)

    RECRUITING

    Hamburg, 20095, Germany

  • Hospital Universitario la Fe ( Site 7107)

    RECRUITING

    Valencia, 46026, Spain

  • Hospital Vall d' Hebron ( Site 7101)

    RECRUITING

    Barcelona, 08029, Spain

  • Hospital Viamed Santa Elena ( Site 7105)

    RECRUITING

    Madrid, 28003, Spain

  • Hospital of the University of Pennsylvania ( Site 5134)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • International Center for Research ( Site 5124)

    RECRUITING

    Tampa, Florida, 33618, United States

  • Johns Hopkins Bayview Medical Center - Johns Hopkins Asthma & Allergy Center ( Site 5132)

    RECRUITING

    Baltimore, Maryland, 21224, United States

  • Joint and Muscle Research Institute ( Site 5108)

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Joseph S. and Diane H. Steinberg Ambulatory Care Center ( Site 5106)

    RECRUITING

    Brooklyn, New York, 11201, United States

  • Kansas City Physician Partners ( Site 5119)

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain ( Site 7401)

    RECRUITING

    Kiev, Kyiv Oblast, 03049, Ukraine

  • Limited liability company "Medical center Health Clinic" ( Site 7412)

    RECRUITING

    Vinnytsia, Vinnytsia Oblast, 21009, Ukraine

  • Lviv Clin Hospital of Planned Treatment Rehabilitation Palliative Care ( Site 7410)

    RECRUITING

    Lviv, Lviv Oblast, 79011, Ukraine

  • MICS Centrum Medyczne Bydgoszcz ( Site 6907)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-065, Poland

  • MICS Centrum Medyczne Torun ( Site 6903)

    RECRUITING

    Torun, Kuyavian-Pomeranian Voivodeship, 87-100, Poland

  • MICS Centrum Medyczne Warszawa ( Site 6905)

    RECRUITING

    Warsaw, Masovian Voivodeship, 00-874, Poland

  • Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 7406)

    RECRUITING

    Kyiv, 03057, Ukraine

  • Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 7415)

    RECRUITING

    Kyiv, Kyivska Oblast, 04050, Ukraine

  • Medvin Clinical Research - Riverside ( Site 5115)

    RECRUITING

    Riverside, California, 92508, United States

  • Medvin Clinical Research - Tujunga ( Site 5113)

    RECRUITING

    Tujunga, California, 91042, United States

  • Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical Hospital n.a. M. I. Pyrohov of Vinnytsia ( Site 7400)

    RECRUITING

    Vinnytsia, Vinnytsia Oblast, 21028, Ukraine

  • Narodowy Instytut Geriatrii Reumatologii i Rehabilitacji im.Prof. El. Reicher-ul.Spartanska 1 ( Site 6906)

    ACTIVE_NOT_RECRUITING

    Warsaw, Masovian Voivodeship, 02-637, Poland

  • Physician Research Collaboration, LLC ( Site 5102)

    RECRUITING

    Lincoln, Nebraska, 68516, United States

  • Rheuma-Research Lausitz ( Site 6409)

    RECRUITING

    Cottbus, Brandenburg, 03042, Germany

  • Rheumatologische Schwerpunktpraxis ( Site 6405)

    RECRUITING

    Berlin, 10777, Germany

  • Rheumazentrum Ruhrgebiet ( Site 6400)

    RECRUITING

    Herne, North Rhine-Westphalia, 44649, Germany

  • St. Luke's Clinic - Rheumatology - Boise ( Site 5109)

    RECRUITING

    Boise, Idaho, 83702-4565, United States

  • Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy ( Site 6904)

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland

  • Zespół Poradni Specjalistycznych Reumed Filia nr 1 Wallenroda ( Site 6901)

    ACTIVE_NOT_RECRUITING

    Lublin, Lubusz Voivodeship, 20-607, Poland

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