New study tests rinvoq for psoriatic arthritis spine pain

NCT ID NCT06454188

Recruiting now Disease control Sponsor: CARE ARTHRITIS LTD. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether upadacitinib (Rinvoq), a daily pill, can reduce inflammation in the spine and joints of people with active psoriatic arthritis. About 100 adults who have not responded well to other treatments will receive either the drug or a placebo for 12 weeks. Researchers will use MRI scans and symptom scores to measure changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: upadacitinib (Rinvoq)
What this could lead to: If successful, this could show that upadacitinib effectively reduces spinal and joint inflammation in people with psoriatic arthritis, offering a new treatment option.
What could go wrong: This is a phase 4 trial with only 100 participants, so results may not apply to everyone. Upadacitinib can have side effects like infections, and the placebo group may also show improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Axial Spondyloarthritis psoriatic arthritis spondyloarthropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIATIC ARTHRITIS SPONDYLOARTHRITIS, AXIAL

Contacts and locations

Locations

Groupe de Recherche en Maladies Osseuses (G.R.M.O.) Inc.
RECRUITING

Québec, Quebec, G1V 3M7, Canada
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
The Ottawa Hospital Research Institute
RECRUITING

Ottawa, Ontario, K1H 7W9, Canada
University Hospitals Cleveland Medical Center
RECRUITING

Cleveland, Ohio, 44106, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

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