New pill could ease psoriatic arthritis without biologics

NCT ID NCT06671483

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 7 times

Summary

This Phase 3 study tests whether the oral drug zasocitinib (TAK-279) can improve symptoms of active psoriatic arthritis in people who have never used biologic treatments. About 1,088 adults will receive either zasocitinib, an active comparator, or a placebo for up to 60 weeks. The main goal is to see if more participants achieve at least a 20% improvement in joint and skin symptoms by week 16 compared to placebo.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Zasocitinib (TAK-279), an oral tablet
What this could lead to: If successful, zasocitinib could offer a new oral treatment option for people with psoriatic arthritis who have not yet tried biologic drugs, potentially reducing joint pain and swelling.
What could go wrong: This is a Phase 3 trial, but results are not yet known. The drug may not work better than placebo or existing treatments, and side effects could emerge. Long-term safety and effectiveness are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PSORIATIC ARTHRITIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

AARR- Chandler AZ
RECRUITING

Chandler, Arizona, 85225, United States
AES Partner Site -Plovdiv
RECRUITING

Plovdiv, 4000, Bulgaria
ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO
RECRUITING

Milan, Lombardy, 20122, Italy
Accellacare of Hickory
RECRUITING

Hickory, North Carolina, 28602, United States
Accurate Clinical Research
RECRUITING

Baytown, Texas, 77521, United States
Accurate Clinical Research
RECRUITING

Houston, Texas, 77089, United States
Accurate Clinical Research, Inc. | Lake Charles
RECRUITING

Lake Charles, Louisiana, 70605, United States
Ajou University Hospital | Clinical Trial Center
RECRUITING

Suwon, Gyeonggido, 16499, South Korea
Albuquerque Center for Rheumatology PC
RECRUITING

Albuquerque, New Mexico, 87102-1710, United States
Ambulatorium Sp. z o.o.
RECRUITING

Elblag, Warmian-Masurian Voivodeship, 82-300, Poland
Aotearoa Clinical Trials
RECRUITING

Auckland, North Island, 2025, New Zealand
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85032, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85032, United States
Arizona Arthritis & Rheumatology Research, PLLC | Phoenix, AZ
RECRUITING

Phoenix, Arizona, 85306, United States
Arthritis & Rheumatic Disease Specialties (AARDS)
RECRUITING

Aventura, Florida, 33180, United States
Arthritis Northwest, PLLC | Spokane, WA
RECRUITING

Spokane, Washington, 99204, United States
Asan Medical Center
RECRUITING

Seoul, 05505, South Korea
Ash Research Clinic - Howell
RECRUITING

Howell, Michigan, 48843, United States
Assuta Ashdod Medical Center
RECRUITING

Ashdod, Southern District, 7747629, Israel
Azienda Ospedale Università Padova
RECRUITING

Padova, Veneto, 35128, Italy
Azienda Ospedaliera Universitaria Careggi
RECRUITING

Florence, 50134, Italy
Azienda Ospedaliero Universitaria Pisana
RECRUITING

Pisa, 56126, Italy
Azienda Ospedaliero-Universitaria delle Marche; SOD Clinica Medica
RECRUITING

Torrette, Ancona, 60126, Italy
Barzilai Medical Center | Rheumatology Department
RECRUITING

Ashkelon, 7830604, Israel
Bif-Med s.c. NZOZ
RECRUITING

Bytom, Silesian Voivodeship, 41-902, Poland
Bioresearch Partners
RECRUITING

Miami, Florida, 33143, United States
CCR Ostrava
RECRUITING

Ostrava, Moravian-Silesian Region, 702 00, Czechia
CGM Research Trust
RECRUITING

Christchurch Central, Christchurch, 8013, New Zealand
CINTRE, Centro de Investigacion y Tratamiento Reumatologico S.C.
RECRUITING

Mexico City, Mexico City, 11850, Mexico
CMed Rehabilitacios es Diagnosztikai Kozpont
RECRUITING

Székesfehérvár, Fejér, 8000, Hungary
CTR Estudios
RECRUITING

Santiago, 8320000, Chile
Center for Clinical and Basic Research
RECRUITING

Tallinn, Harju, 10128, Estonia
Centre Hospitalier Universitaire (CHU) de Liege - Domaine Universitaire du Sart Tilman
RECRUITING

Liège, 4000, Belgium
Centre of Rheumatology St. Irina
RECRUITING

Sofia, Sofia-Grad, 1784, Bulgaria
Centro Hospitalar Universitario de Lisboa Norte | Hospital Santa Maria - Rheumatology Department
RECRUITING

Lisbon, 1649-035, Portugal
Centro Hospitalar de Vila Nova de Gaia / Espinho E.P.E
RECRUITING

Vila Nova de Gaia, New Mexico, 4434-502, Portugal
Centro Hospitalar e Universitário de Coimbra E.P.E - Hospitais da Universidade de Coimbra
RECRUITING

Coimbra, Barcelona, 3004-561, Portugal
Centro Integral en Reumatologia, S.A. de C.V.
RECRUITING

Guadalajara, Jalisco, 44160, Mexico
Centro Internacional de Estudios Clínicos
RECRUITING

Santiago, 8420383, Chile
Centro Reumatologico de Caguas | Caguas, PR
RECRUITING

Caguas, 00725, Puerto Rico
Centro de Estudios Clinicos
RECRUITING

Santiago, 8320000, Chile
Centro de Investigacion en Artritis y Osteoporosis S.C. (CIAO)
RECRUITING

Mexicali, Estado de Baja California, 21200, Mexico
Centrum Medyczne Katowice - PRATIA
RECRUITING

Katowice, Lower Silesian Voivodeship, 40-081, Poland
Centrum Medyczne Plejady
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-363, Poland
Centrum Medyczne Reuma Park
RECRUITING

Warsaw, Masovian Voivodeship, 02-665, Poland
Chi Mei Medical Center
RECRUITING

Tainan, 710, Taiwan
Chung Shan Medical University Hospital
RECRUITING

Taichung, 40201, Taiwan
Clinica Dermacross S.A.
RECRUITING

Santiago, Santiago Metropolitan, 7640881, Chile
Clinical Hospital Center Rijeka
RECRUITING

Rijeka, 51000, Croatia
Clinical Hospital Centre Osijek
RECRUITING

Osijek, 31000, Croatia
Clinical Investigations of Texas
RECRUITING

Plano, Texas, 75075, United States
Clinical Research Centre | Tartu, Estonia
RECRUITING

Tartu, Tartu, 50106, Estonia
Clinical Research Institute of Michigan
RECRUITING

Saint Clair Shores, Michigan, 48081, United States
Clinical Research of West Florida | Clearwater, FL
RECRUITING

Clearwater, Florida, 33765, United States
Clinical Research of West Florida | Tampa, FL
RECRUITING

Tampa, Florida, 33606, United States
Clintrial s.r.o. | Prague, Czech Republic
RECRUITING

Prague, Czech Rep, 100 00, Czechia
Consultorio de Reumatologia
RECRUITING

Gustavo Adolfo Madero, Mexico City, 07760, Mexico
Corporacio Sanitaria Parc Tauli - Hospital de Sabadell
RECRUITING

Sabadell, Barcelona, 08208, Spain
D. Saulites Kandevicas Private Practice in Cardiology and Rheumatology | Liepaja, Latvia
RECRUITING

Liepāja, 3401, Latvia
Denver Arthritis Clinic | Denver, CO
RECRUITING

Denver, Colorado, 80230, United States
Diagnostic Consultative Centre - Focus-5 - LZIP EOOD
RECRUITING

Sofia, Sofia-Grad, 1463, Bulgaria
Diagnostic- Consultative Center- 1- Ruse EOOD
RECRUITING

Rousse, 7002, Bulgaria
Dr Stoyanka Vladeva IPSMP VBR | Stara Zagora, Bulgaria
RECRUITING

Stara Zagora, 6000, Bulgaria
Driven Research LLC
RECRUITING

Coral Gables, Florida, 33134-3901, United States
ETG Warszawa Sp. z o.o.
RECRUITING

Warsaw, Masovian Voivodeship, 02-677, Poland
El Centro de Estudios Reumatologicos (CER)
RECRUITING

Providencia, Santiago Metropolitan, 7500000, Chile
Etyka Osrodek Badan Klinicznych | Olsztyn, Poland
RECRUITING

Olsztyn, Warmian-Masurian Voivodeship, 10-117, Poland
Fachklinik Bad Bentheim
RECRUITING

Bad Bentheim, Lower Saxony, 48455, Germany
Far Eastern Memorial Hospital | Allergy, Immunology and Rheumatology Department
RECRUITING

New Taipei City, 220, Taiwan
Fejer Varmegyei Szent Gyorgy Egyetemi Oktató Korhaz | Rheumatology Department - Arthritis Center
RECRUITING

Székesfehérvár, 8000, Hungary
First OC Dermatology Research Inc.
RECRUITING

Fountain Valley, California, 92708, United States
Fondazione PTV Policlinico Tor Vergata
RECRUITING

Rome, Lazio, 00133, Italy
Foothill Arthritis Clinic
RECRUITING

Tujunga, California, 91042, United States
FutureMeds Wroclaw
RECRUITING

Wroclaw, 53-673, Poland
FutureMeds | Lodz Center - Lodz, Poland
RECRUITING

Lodz, 91-363, Poland
GCM Medical Group, PSC | San Juan, PR
RECRUITING

San Juan, 00917, Puerto Rico
GNP Research, LLC | Hollywood, FL
RECRUITING

Cooper City, Florida, 33024, United States
GSCP/CIS
RECRUITING

Orland Park, Illinois, 60467, United States
Galilee Medical Center | Rheumatology Unit
RECRUITING

Nahariya, 2210001, Israel
General Hospital Zadar
COMPLETED

Zadar, 23000, Croatia
Greater Chicago Specialty Physicians LLC/CIS
RECRUITING

Schaumburg, Illinois, 60195, United States
HMD Research LLC
RECRUITING

Orlando, Florida, 32819, United States
HMG Hospital Coyoacan
WITHDRAWN

Mexico City, Mexico City, 06720, Mexico
Henry Ford Health System-Rheumatology Department
WITHDRAWN

Detroit, Michigan, 48202, United States
Hospital Clinico Universitario de Santiago de Compostela | Building A - Rheumatology Department
RECRUITING

Santiago de Compostela, Galicia, 15706, Spain
Hospital Clinico Universitario de Valencia
RECRUITING

Valencia, 46010, Spain
Hospital Conde de Bertiandos Unidade Local de Saúde Do Alto Minho
RECRUITING

Ponte de Lima, Barcelona, 4990-041, Portugal
Hospital Garcia de Orta
RECRUITING

Almada, 2805-267, Portugal
Hospital Regional Universitario de Malaga
RECRUITING

Málaga, 29010, Spain
Hospital Universitario Virgen Macarena
RECRUITING

Seville, 41009, Spain
Hospital Universitario de Badajoz
RECRUITING

Mérida, Badajoz, 06006, Spain
Hospitales Star Medica
RECRUITING

Mérida, Yucatán, 97133, Mexico
INTER CLINIC Piotr Adrian Klimiuk | Bialystok, Poland
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-077, Poland
IRCCS Istituto Clinico Humanitas
RECRUITING

Rozzano, Milano, 20089, Italy
IRIS Research and Development | Plantation, FL
RECRUITING

Plantation, Florida, 33324, United States
Innomedica OU | Tallinn, Estonia
RECRUITING

Tallinn, Harju, 10117, Estonia
Instituto Portugues de Reumatologia
RECRUITING

Lisbon, 1050-034, Portugal
Introscience Research | Northwest Houston Arthritis Center - Houston, TX
RECRUITING

Houston, Texas, 77090, United States
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
RECRUITING

Milan, Lombardy, 20132, Italy
June DO, PC Private Practice - Dr. Justus Fiechtner
RECRUITING

Lansing, Michigan, 48911-4285, United States
Klein & Associates, M.D., P.A.
RECRUITING

Hagerstown, Maryland, 21740, United States
Kohler and Milstein Research Yucatan
RECRUITING

Mérida, Yucatán, 97070, Mexico
Krakowskie Centrum Medyczne
RECRUITING

Krakow, Lesser Poland Voivodeship, 31-501, Poland
Kyung Hee University Hospital
RECRUITING

Seoul, 2447, South Korea
L.K.N. Arthrocentrum, s.r.o. - Revmatologicka
ACTIVE_NOT_RECRUITING

Hlučín, Czech Rep, 92307, Czechia
MEDICAL Plus s.r.o.
RECRUITING

Uherské Hradiště, Czech Rep, 68601, Czechia
MICS Centrum Medyczne Torun
RECRUITING

Torun, Silesian Voivodeship, 87-100, Poland
MTZ Clinical Research Powered by PRATIA
RECRUITING

Warsaw, Masovian Voivodeship, 02-172, Poland
MVZ Rheumatologie und Autoimmunmedizin Hamburg GmbH - Hamburg
RECRUITING

Hamburg, 20095, Germany
Marietta Rheumatology Associates
RECRUITING

Marietta, Georgia, 30060, United States
MediTrials OÜ
RECRUITING

Tartu, 50708, Estonia
Medical Center Artmed OOD | Plovdiv, Bulgaria
RECRUITING

Plovdiv, 4000, Bulgaria
Medical Center Medconsult Pleven OOD
RECRUITING

Pleven, 5800, Bulgaria
Medical Center Zara-Med EOOD
RECRUITING

Stara Zagora, 6000, Bulgaria
Medicinski Centar Kuna and Peric
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
Medicover MVZ München Ost
RECRUITING

München, 81667, Germany
Medvin Clinical Research
RECRUITING

Whittier, California, 90602-1005, United States
Michigan Rheumatology Group, P.C. - Grand Blanc Office
RECRUITING

Grand Blanc, Michigan, 48439-2451, United States
Military Medical Academy Multiprofile Hospital for Not Yet Recruiting Treatment - Sofia
RECRUITING

Sofia, Sofia-Grad, 1606, Bulgaria
Millennium Research | Ormond Beach, FL
RECRUITING

Ormond Beach, Florida, 32174, United States
NYU Langone Health | Joseph S. and Diane H. Steinberg Ambulatory Care Center - Rheumatology Department
RECRUITING

Brooklyn, New York, 11201, United States
Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. prof. dr hab. med. Eleonory Reicher, Centrum Wsparcia Badań Klinic
RECRUITING

Warsaw, Masovian Voivodeship, 02-637, Poland
National Cheng Kung University
RECRUITING

Tainan, Tainan City, 701, Taiwan
National Taiwan University Hospital
RECRUITING

Zhong Zheng Qu, Taipei City, 100, Taiwan
North Estonia Medical Centre | Mustamae Building - Internal Medicine Clinic - Rheumatology Department
RECRUITING

Tallinn, 13419, Estonia
North Shore Hospital
RECRUITING

Auckland, North Island, 6022, New Zealand
Nova Reuma Domyslawska i Rusilowicz- Spolka Partnerska Lekarza Reumatologa i Fizjoterapeuty
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-077, Poland
Novel Research | Bellaire Location
RECRUITING

Houston, Texas, 77024, United States
Novel Research | Bellaire Location
RECRUITING

Houston, Texas, 77024, United States
ORTO Clinic | Rheumatology Department
RECRUITING

Riga, LV-1005, Latvia
Office of Cesar F. Pacheco-Tena, MD
RECRUITING

Chihuahua City, 31000, Mexico
PA Regional Center for Arthritis and Osteoporosis Research
RECRUITING

Wyomissing, Pennsylvania, 19610-3206, United States

Contact Email: •••••@•••••
Paramount Medical Research & Consulting, LLC
RECRUITING

Middleburg Heights, Ohio, 44130, United States
Policlinico Agostino Gemelli, UOC Reumatology
RECRUITING

Rome, Lazio, 168, Italy
Porcika Klinika
RECRUITING

Hódmezővásárhely, Csongrad-Csanad, 6800, Hungary
Porter Rheumatology Ltd
RECRUITING

Nelson, South Island, 7010, New Zealand
Praglandia | Prague, Czech Republic
RECRUITING

Prague, Czech Rep, 150 00, Czechia
Pratia MCM Krakow
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-727, Poland
Pratia Pardubice a.s.
RECRUITING

Pardubice, 53002, Czechia
Pratia Poznań
RECRUITING

Poznan, Greater Poland Voivodeship, 60-192, Poland
Private Practice - Dr. Delfina Villanueva Quintero
RECRUITING

Guadalajara, Jalisco, 44600, Mexico
Prywatna Praktyka Lekarska Prof. dr hab. med. Pawel Hrycaj | Poznan, Poland
RECRUITING

Poznan, Woj. Wielkopolskie, 61-397, Poland
Purushotham & Akther Kotha MD
RECRUITING

La Mesa, California, 91942, United States
Pv Medical Services
RECRUITING

Zlín, NAP, 760 01, Czechia
Qualiclinic | Budapest, Hungary
RECRUITING

Budapest, 1036, Hungary
RASF- Clinical Research Center
RECRUITING

Boca Raton, Florida, 33486-1390, United States
RCMed | Sochaczew, Poland
RECRUITING

Sochaczew, Masovian Voivodeship, 96-500, Poland
Rambam Health Care Campus
RECRUITING

Haifa, 3109601, Israel
ReumaClinic Genk
RECRUITING

Genk, Limburg, 3600, Belgium
Reumedika | Poznan, Poland
RECRUITING

Poznan, Wlkp, 60-446, Poland
Revmatologicky ustav | Clinical Evaluation Department
RECRUITING

Prague, Prague, 12800, Czechia
Revmatologie s.r.o. | Brno, Czech Republic
RECRUITING

Brno, Czech Rep, 63800, Czechia
Rheuma Medicus | Warsaw, Poland
RECRUITING

Warsaw, Masovian Voivodeship, 02-118, Poland
Rheumatologische Schwerpunktpraxis | Berlin, Germany
RECRUITING

Berlin, 12161, Germany
Rheumazentrum Ratingen-Studienambulanz
RECRUITING

Ratingen, North Rhine-Westphalia, 40878, Germany
Rheumzentrum Prof.Dr.med.Gunther Neeck
RECRUITING

Bad Doberan, Mecklenburg-Vorpommern, 18209, Germany
SMG - SNU Boramae Medical Center
RECRUITING

Seoul, 07061, South Korea
Saint Louis Rheumatology
RECRUITING

St Louis, Missouri, 63119, United States
Santa Familia PTG Lodz | Lodz, Poland
RECRUITING

Lodz, 90-302, Poland
Santa Fe Rheumatology
RECRUITING

Santa Fe, New Mexico, 87505-1102, United States
Sarasota Arthritis Research Center
RECRUITING

Sarasota, Florida, 34239, United States
Southwest Rheumatology Research, LLC | Mesquite, TX
RECRUITING

Mesquite, Texas, 75150, United States
St Pierre Brussels
RECRUITING

Brussels, 1000, Belgium
Städtisches Klinikum Dresden
RECRUITING

Dresden, 01067, Germany
Sweet Hope Research Specialty, Inc, d/b/a Neoclinical Research
RECRUITING

Hialeah, Florida, 33016, United States
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
RECRUITING

Szeged, Csongrad-Csanad, 6720, Hungary
Tectum Medical Research
RECRUITING

Davie, Florida, 33024, United States
Tel Aviv Sourasky Medical Center
RECRUITING

Tel Aviv, 6423906, Israel
The Catholic University of Korea
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
The Chaim Sheba Medical Center - The Zabludowicz Center for Autoimmune Diseases
RECRUITING

Ramat Gan, 5265601, Israel
The Cohen Medical Centers
RECRUITING

Thousand Oaks, California, 91360-3967, United States
Triwest Research Associates LLC
RECRUITING

La Mesa, California, 91942, United States
Twoja Przychodnia - Poznanskie Centrum Medyczne Sp. z o.o.
RECRUITING

Poznan, Wielkopolska, 60-324, Poland
Twoja Przychodnia Opolskie Centrum Medyczne
RECRUITING

Opole, Opole Voivodeship, 45-819, Poland
Twoja Przychodnia | Nowa Sol, Poland
RECRUITING

Nowa Sól, 67-100, Poland
UNICA CR sp. z.o. o.
RECRUITING

Dąbrówka, Warmian-Masurian Voivodeship, 62-069, Poland
Universitaetsklinikum Leipzig AoeR
RECRUITING

Leipzig, Saxony, 4103, Germany
University Hospital Centre Split
RECRUITING

Split, 21000, Croatia
University Hospital Ghent
RECRUITING

Ghent, Flanders, 9000, Belgium
University Hospitals | UH Cleveland Medical Center - Department of Medicine - Rheumatology Division
RECRUITING

Cleveland, Ohio, 44106, United States
Université Libre de Bruxelles
RECRUITING

Anderlecht, Brussels Capital, 1070, Belgium
Vital Medical Center Medical Center and Dental Center | Reumatologia - Veszprem, Hungary
RECRUITING

Veszprém, 8200, Hungary
Waikato Hospital
RECRUITING

Hamilton, Waikato Region, 8011, New Zealand
West Broward Rheumatology Associates, Inc.
RECRUITING

Tamarac, Florida, 33321, United States
West Tennessee Research Institute
RECRUITING

Jackson, Tennessee, 38305, United States

Contact Email: •••••@•••••
West Texas Clinical Research
RECRUITING

Lubbock, Texas, 79424, United States
Zdrowie Osteo Medic sc L i A Racewicz, A i J Supronik
RECRUITING

Bialystok, Podlaskie Voivodeship, 15-351, Poland
iBiomed Guadalajara
RECRUITING

Zapopan, Guadalajara, 44160, Mexico

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