Takeda

This study is testing a vaccine designed to prevent dengue fever in adults aged 45 to 79. Researchers want to see how safe the vaccine is and how well it triggers an immune response, especially in older adults and people with other health conditions like diabetes or high blood pr…

This study aims to see how well an approved dengue vaccine works in a real-world public health program. It will follow 70,000 children and adolescents in Southeast Asia for three years, comparing hospitalization rates for dengue between those who get the vaccine and those who don…

This program provides continued access to an investigational drug called vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. It is for participants who were already benefiting from the drug in a previous clinical study and have no…

This study is testing an investigational drug called KER-050 (elritercept) to see if it is safe and can help people with myelofibrosis, a serious bone marrow cancer. The drug is designed to help the body make more red blood cells and platelets, which could reduce anemia and other…

This study is testing a new drug called elritercept against a standard drug (epoetin alfa) for adults with a bone marrow disorder (MDS) who have anemia and need regular blood transfusions. The main goal is to see if elritercept can help patients go longer periods without needing …

This study is testing a new treatment called VONVENDI, sometimes given with another drug called ADVATE, to see if it safely and effectively controls bleeding episodes in Chinese adults with Von Willebrand Disease (VWD). The goal is to help people with VWD manage bleeding during s…

This study is testing whether a daily oral medication called vortioxetine is safe and effective at reducing depression symptoms in Japanese teenagers aged 12 to 17. About 180 participants will be randomly assigned to receive either the real medication or a placebo (a pill with no…

This is an early-stage study to check the safety of a new drug called TAK-781. It will first be given to healthy volunteers to see how their bodies handle it. Then, a single dose will be given to a small group of people with a specific chronic liver disease called primary scleros…

This study aims to see how the drug maribavir is used and how well it works for controlling cytomegalovirus (CMV) infections in adults who have had a transplant. Researchers will follow about 75 patients in Belgium for up to 2 years, collecting data from their regular doctor visi…

This study is testing whether a new oral medication called TAK-279 can reduce inflammation and symptoms in adults with moderate to severe ulcerative colitis. For the first 12 weeks, participants will be randomly assigned to receive either TAK-279 or a placebo pill, and then all p…

This study aims to monitor the long-term safety and effectiveness of an approved injection treatment for spinal and bulbar muscular atrophy (SBMA) in real-world medical settings. It will observe about 300 patients in Japan who are already receiving the treatment, tracking their h…

This study is monitoring the safety and effectiveness of the lung cancer drug brigatinib in real-world medical settings in South Korea. It will follow about 257 adults with ALK-positive advanced lung cancer who are starting brigatinib treatment for the first time. The main goal i…

This study is testing a combination of four drugs for adults in India with advanced Hodgkin lymphoma who haven't had any previous treatment. The main goal is to check how safe this treatment is and how well it works to control the cancer. Participants will receive the drug combin…

This study is testing whether an intravenous medication called vedolizumab can safely reduce symptoms and intestinal inflammation in Chinese adults with moderate to severe Crohn's disease. About 408 participants will receive either the drug or a placebo for 14 weeks, then all wil…

This study is testing whether a new drug called mezagitamab, given as an injection under the skin, can help adults with chronic immune thrombocytopenia (ITP) maintain safe platelet levels. ITP is a condition where the immune system mistakenly destroys platelets, increasing the ri…

This study is testing whether a modified form of immunoglobulin called TAK-411 can improve physical function and reduce symptoms in adults with CIDP, a rare autoimmune disease that damages nerves and causes muscle weakness. About 36 participants who have previously responded to s…

This study is testing a drug called fazirsiran for people with liver disease caused by Alpha-1 antitrypsin deficiency. The drug aims to reduce the buildup of an abnormal protein that causes liver scarring. About 50 adults with early-stage liver scarring will receive either the dr…

This study is testing a medication called vedolizumab to see if it can help children and teenagers with moderate to severe Crohn's disease who haven't gotten better with other standard treatments. About 120 participants will receive the drug through an IV to try to reduce gut inf…

This study is monitoring the long-term safety and effectiveness of a cell-based injection (darvadstrocel) for treating complex anal fistulas in people with Crohn's disease. It will follow about 275 patients in Japan for three years after they receive the injection as part of thei…

This study is observing how well the medication brentuximab vedotin works for adults with Hodgkin's lymphoma who have undergone stem cell transplants. Researchers will follow 70 participants in Poland for two years to see how long they remain cancer-free and monitor treatment saf…

This study aims to understand how well a manufactured enzyme therapy works for people in China living with Fabry disease, a rare inherited disorder. Researchers will observe 200 children and adults who are already receiving this standard treatment in their regular care. The main …

This study compares a new drug called TAK-330 against standard treatment to quickly reverse blood thinners in people who need emergency surgery. Adults taking common blood thinners like apixaban or rivaroxaban who require urgent procedures with high bleeding risk may participate.…

This study is testing whether using two different medications together works better than one alone for adults with moderate to severe Crohn's disease who haven't responded well to previous treatments. About 100 participants will first receive a combination of two drugs, then cont…

This program allows children and adults with severe Von Willebrand Disease (VWD) to continue receiving an experimental treatment they benefited from in a previous study. It's for patients who have no other good treatment options available in their country and would be harmed if t…

This study is monitoring the safety and real-world effectiveness of vedolizumab injections in 600 Korean adults with ulcerative colitis or Crohn's disease. Participants have already tried other treatments without success and are receiving vedolizumab as part of their regular care…

This study is testing a new drug called TAK-188 in adults with advanced solid tumors that have not gotten better with standard treatments. TAK-188 is designed to help the body's own immune system fight cancer by targeting specific cells inside tumors that weaken the immune respon…

This study is testing a new oral medication called zasocitinib for people with active psoriatic arthritis, a condition that causes joint pain and skin plaques. The main goal is to see if the drug is better than a placebo at reducing joint swelling and tenderness and improving ski…

This study is testing an experimental medication called TAK-360 for adults with narcolepsy type 2, a condition that causes severe daytime sleepiness. Researchers want to find a safe and effective dose that helps people stay awake and alert. About 88 participants will be randomly …

This study is testing whether a new oral medication called TAK-279 can reduce inflammation and ulcers in the bowel for people with moderate to severe Crohn's disease. About 268 adults who haven't gotten enough relief from their current treatments will take one of three doses of T…

This study is testing if an investigational drug called TAK-861 can effectively control the symptoms of narcolepsy type 1, a sleep disorder that causes severe daytime sleepiness and sudden muscle weakness (cataplexy). About 88 participants worldwide will take the drug for several…

This study is monitoring the use of Maribavir tablets in Japan for patients who have received an organ or stem cell transplant and developed a Cytomegalovirus (CMV) infection that hasn't responded to other treatments. The main goals are to check how well the drug works to clear t…

This study is testing whether a lab-made clotting factor called vonicog alfa can safely prevent bleeding episodes in children with severe Von Willebrand Disease (VWD). It will enroll 24 children under 18 who have previously been treated for VWD. Participants will receive the trea…

This study is testing an oral medication called zasocitinib to see if it can help restore skin color in adults with nonsegmental vitiligo, an autoimmune condition that causes white patches on the skin. About 200 participants will be randomly assigned to receive either the study d…

This study aims to learn about the long-term safety of vedolizumab injections in children and teenagers with ulcerative colitis or Crohn's disease. About 70 participants who responded well to the treatment in a previous study will continue receiving injections for up to 2 years, …

This study is testing whether a medication called vedolizumab, given as an injection under the skin, can help control symptoms and achieve remission in people with moderate to severe ulcerative colitis or Crohn's disease. About 400 participants will receive the treatment for abou…

This study is monitoring how safe and effective a treatment called vonicog alfa is for children under 18 with Von Willebrand Disease, a rare bleeding disorder. Doctors in Japan will observe about 13 children receiving this treatment during normal medical care for bleeding episode…

This study is testing whether an investigational drug called fazirsiran can reduce liver scarring (fibrosis) in people with Alpha-1 antitrypsin deficiency, a genetic condition that can damage the liver and lungs. About 160 adults with moderate to advanced liver scarring will rece…

This study is testing whether a new oral medication called zasocitinib can help control the joint pain, swelling, and skin symptoms of psoriatic arthritis. It will involve about 1,100 adults who have active disease but have not yet tried advanced biologic injections. Participants…

This study is observing how well an existing drug called teduglutide works for children and teenagers with short bowel syndrome, a rare condition where their intestines can't absorb enough nutrients from food. The main goal is to see if the drug helps them reduce their dependence…

This study is testing a new oral medication called zasocitinib to see if it can effectively control skin symptoms and improve quality of life for children and teenagers with moderate-to-severe plaque psoriasis. It will involve about 110 participants aged 4 to under 18, comparing …

This study aims to check the long-term safety of an oral medication called zasocitinib (TAK-279) for adults with active Crohn's disease or ulcerative colitis. It is an extension for up to two years for people who benefited from the drug in earlier, shorter studies. The main goal …

This study is monitoring the safety and effectiveness of the drug ADZYNMA in patients with congenital Thrombotic Thrombocytopenic Purpura (cTTP), a rare and serious blood clotting disorder. It will observe about 40 patients in Japan for 18 months to track any side effects and see…

This study is monitoring the safety and effectiveness of the approved drug LIVTENCITY (maribavir) when used in routine medical practice. It will follow 168 adults in South Korea who have a difficult-to-treat CMV infection after an organ or stem cell transplant. The goal is to col…

This study is testing whether a drug called vedolizumab, given as an IV infusion, can help control moderate to severe ulcerative colitis over the long term. It will involve about 402 Chinese adults whose symptoms haven't improved enough with standard treatments. Participants will…

This study is testing an intravenous medication called vedolizumab to see if it can reduce inflammation and improve symptoms in children with chronic pouchitis. Pouchitis is a painful swelling and infection that can occur in a surgically created pouch after the large bowel is rem…

This study is testing an investigational oral medication called zasocitinib for adults with moderate to severe hidradenitis suppurativa (HS), a chronic and painful skin condition. For the first 4 months, participants will be randomly assigned to receive either the study drug or a…

This study aims to understand how well the preventive medication Takhzyro (lanadelumab) works for children with hereditary angioedema (HAE) in everyday life. It will look at the medical records of about 40 children, aged 2 to under 12, who are already taking Takhzyro to prevent s…

This study is testing an oral drug called maribavir in Chinese adults who have had a transplant and have a cytomegalovirus (CMV) infection that has not responded to standard antiviral treatments. The main goals are to see how safe the drug is, how well patients tolerate it, and i…

This study aims to see if a new treatment called TAK-881 works similarly to an existing treatment called HYQVIA for adults with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). Participants who are already receiving immunoglobulin therapy will switch to HYQVIA fo…

This study is testing an investigational drug called mezagitamab to see if it can help adults with IgA nephropathy, a condition where the immune system damages the kidneys. The main goal is to see if the drug reduces protein in the urine and helps protect long-term kidney functio…

This study is testing an investigational drug called elritercept to see if it can help adults with a lower-risk type of myelodysplastic syndrome (MDS) become less dependent on regular red blood cell transfusions. About 225 participants will receive either the drug or a placebo vi…

This study aims to check the long-term safety and side effects of the drug TAK-861 in people with type 1 narcolepsy. It will follow up to 500 participants for about 5 years to see how well they tolerate the medication over time. The study also tracks changes in key narcolepsy sym…

This study is checking the long-term safety and effectiveness of an injectable drug called mezagitamab for adults with chronic immune thrombocytopenia (ITP), a condition where the immune system attacks blood platelets. It is a continuation study for about 150 people who have alre…

This study observes how patients with multiple myeloma and weakened immune systems use HyQvia treatment during routine medical care. Researchers will track how the treatment is given, including dosage, timing, and any side effects, to understand real-world practice. The study inv…

This study is testing an investigational drug called KER-050 (elritercept) to see if it can safely help the body make more healthy red blood cells in adults with lower-risk myelodysplastic syndromes (MDS) who have anemia. The main goals are to check the drug's safety and see if i…

This study is testing if a medicine called dexlansoprazole can heal and then keep healed a damaged esophagus in children aged 2 to 11. The damage, called erosive esophagitis, is caused by stomach acid rising up. About 76 children will take the medicine daily for up to 10 months t…

This study is testing a new under-the-skin injection form of the drug vedolizumab for children and teenagers with moderate to severe ulcerative colitis or Crohn's disease. About 70 participants who have already responded to the standard IV treatment will receive the injection for…

This study is testing whether starting treatment with two drugs together (vedolizumab and tofacitinib) is effective for adults with moderate to severe ulcerative colitis who haven't gotten enough relief from previous biologic treatments. About 65 participants will receive both dr…

This study aims to understand if the cancer drug fruquintinib causes high blood pressure more often in Black and Hispanic patients with advanced colorectal cancer that has stopped responding to other treatments. It will enroll 78 adults from these groups to monitor their blood pr…

This study is testing whether giving regular antibody infusions (Gammagard) from the start of a new cancer treatment can prevent serious infections better than waiting to treat infections only after they occur. It involves 183 adults with multiple myeloma who are receiving a spec…

This study is testing whether an experimental drug called TAK-360 can help adults with idiopathic hypersomnia stay awake and feel less sleepy during the day. TAK-360 works by mimicking a natural brain chemical called orexin that helps keep people alert. About 96 participants will…

This study is testing if a daily pill called dexlansoprazole can safely reduce heartburn and stomach pain in children aged 2 to 11 who have acid reflux disease (GERD). About 70 children will take one of three different doses, based on their weight, for 12 weeks. Parents and older…

This study aims to understand the risk of liver problems in Japanese children taking Livmarli for two rare liver diseases, Alagille Syndrome (ALGS) and Progressive Familial Intrahepatic Cholestasis (PFIC). Researchers will use an existing medical database to track about 50 patien…

This study aims to check the safety of the drug maribavir in adults who have had an organ or stem cell transplant, have a difficult-to-treat cytomegalovirus (CMV) infection, and also have severe kidney disease or kidney failure. Researchers will look at the existing medical recor…

This study is monitoring the safety of the lung cancer drug Alunbrig (brigatinib) in real-world use in Japan. It will follow 500 patients with a specific advanced lung cancer for one year to track side effects, with a special focus on lung-related problems. The goal is to gather …

This study is a survey to measure how well patients and their doctors understand the safety information and proper use of GATTEX, a medication for Short Bowel Syndrome. It is part of a required safety program for the drug and involves answering questions online, by phone, or on p…

This study aims to learn how liver disease naturally progresses over 5 years in 500 adults with Alpha-1 antitrypsin deficiency (AATD), a genetic condition. Researchers will observe participants without giving any treatment, tracking liver scarring, lung function, and overall heal…

This study aims to find out exactly how many people in Spain have narcolepsy, a rare sleep disorder causing severe daytime sleepiness. Researchers will review hospital records across the country to count diagnosed cases and track how many new cases appear each year. The goal is t…

This study aims to understand why adults with a nerve disorder called CIDP switch to a treatment called HyQvia and how it affects their daily lives. Researchers will follow about 30 people for a year, collecting information through medical records and questionnaires about their s…

This study is monitoring the safety and effectiveness of Fruzaqla (fruquintinib) in real-world colorectal cancer patients in South Korea. Researchers will track side effects and survival outcomes in 600 adults taking this already-approved medication. The goal is to better underst…

This study aims to check the safety of an existing treatment called Cuvitru in people with primary immunodeficiency (PID). Researchers will look back at the medical records of about 100 patients in Japan to see if they experienced specific, serious side effects. The goal is to ga…