New shot for nerve disease could mean fewer infusions

NCT ID NCT06747351

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial is testing whether a new, more concentrated antibody treatment (TAK-881) works similarly to the current standard (HYQVIA) for adults with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). About 59 participants who already receive antibody infusions will switch to HYQVIA for 20 weeks, then TAK-881 for 24 weeks. The main goal is to compare drug levels in the blood, not symptom improvement.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Immune globulin (antibodies) with hyaluronidase, given as a shot under the skin
What this could lead to: If successful, this could show that a more concentrated antibody treatment (TAK-881) works as well as the current standard (HYQVIA) for controlling CIDP, potentially offering a similar option with fewer infusions.
What could go wrong: This is a small, single-arm trial focused on drug levels in the blood, not on whether symptoms improve. It may not prove that TAK-881 is better or even as effective as existing treatments. Side effects from immune globulin can include headaches, allergic reactions, and blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic inflammatory demyelinating polyradiculoneuropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC INFLAMMATORY DEMYELINATING POLYRADICULONEUROPATHY (CIDP)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ASST degli Spedali Civili di Brescia - Spedali Civili di Brescia
NOT_YET_RECRUITING

Brescia, 25123, Italy
Aarhus Universitetshospital
RECRUITING

Aarhus, Central Jutland, 8200, Denmark
Atrium Health Wake Forest Baptist
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Attikon University General Hospital
NOT_YET_RECRUITING

Athens, Attica, 12462, Greece
Az Ospedaliera Universitaria Policlinico G Martino
NOT_YET_RECRUITING

Messina, 98125, Italy
Azienda Ospedaliera Universitaria Policlinico Tor Vergata
NOT_YET_RECRUITING

Rome, 00133, Italy
Azienda Ospedaliero - Universitaria San Luigi Gonzaga
NOT_YET_RECRUITING

Orbassano, Torino, Piemonte, 10043, Italy
Azienda Ospedaliero Universitaria Pisana
NOT_YET_RECRUITING

Pisa, 56126, Italy
BCN Research, LLC
RECRUITING

Greenfield, Wisconsin, 53228, United States
Charite - Universitatsmedizin Berlin
NOT_YET_RECRUITING

Berlin, 12203, Germany
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Clinirem Sp zo.o.
RECRUITING

Lublin, Lublin Voivodeship, 20-064, Poland
Copenhagen University Hospital
NOT_YET_RECRUITING

Copenhagen, Capital Region, 2100d, Denmark
Copernicus Podmiot Leczniczy
NOT_YET_RECRUITING

Gdansk, Pomeranian Voivodeship, 80-462, Poland
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Fakultni nemocnice Hradec Kralove
NOT_YET_RECRUITING

Hradec Králové, 500 05, Czechia
Fondazione Istituto Neurologico Casimiro Mondino
NOT_YET_RECRUITING

Pavia, 27100, Italy
Higashimatsuyama Municipal Hospital
RECRUITING

Higashi-Matsuyama, Saitama, 355-0005, Japan
HonorHealth Neurology
RECRUITING

Scottsdale, Arizona, 85251, United States
Hospital Universitari i Politecnic La Fe
NOT_YET_RECRUITING

Valencia, 46026, Spain
Hospital de La Santa Creu I San Pau
NOT_YET_RECRUITING

Barcelona, 08041, Spain
INECO
NOT_YET_RECRUITING

Rosario, Santa Fe Province, 2000, Argentina
IRCCS Istituto Clinico Humanitas
NOT_YET_RECRUITING

Rozzano, Milano, Lombardia, 20089, Italy
Instituto Argentino de Investigacion Neurologica (IADIN)
NOT_YET_RECRUITING

Buenos Aires, C1015ABR, Argentina
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
NOT_YET_RECRUITING

Milan, Lombardy, 20132, Italy
Japan Organization of Occupational Health and Safety Chubu Rosai Hospital
NOT_YET_RECRUITING

Nagoya, Aichi-ken, 455-8530, Japan
Juntendo University Hospital
RECRUITING

Bunkyo-ku, Tokyo, 113-8431, Japan
Knight Neurology
RECRUITING

Rockledge, Florida, 32955, United States
Kumamoto University Hospital
RECRUITING

Kumamoto, Kumamoto, 860-8556, Japan
Medizinische Hochschule Hannover
NOT_YET_RECRUITING

Hanover, Lower Saxony, 30625, Germany
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Nara Medical University Hospital
NOT_YET_RECRUITING

Kashihara, Nara, 634-8522, Japan
Neurology Associates
RECRUITING

Maitland, Florida, 32751, United States
Neurology Rare Disease Center
RECRUITING

Denton, Texas, 76208, United States
Oddzial Kliniczny Neurologii
NOT_YET_RECRUITING

Krakow, Lesser Poland Voivodeship, 30-688, Poland
Oregon Health & Science University (OHSU) - Nephrology and Hypertension Clinic - Marquam Hill
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
Ospedale San Martino
NOT_YET_RECRUITING

Genova, 16132, Italy
Raleigh Neurology Associates
RECRUITING

Raleigh, North Carolina, 27607, United States
Sahlgrenska Universitetssjukhuset
RECRUITING

Gothenburg, Västra Götaland County, 41345, Sweden
Shiga University of Medical Science Hospital
NOT_YET_RECRUITING

Ōtsu, Shiga, 520-2192, Japan
Stanford Neuroscience Health Center
NOT_YET_RECRUITING

Palo Alto, California, 94304, United States
The University of Vermont Medical Center
NOT_YET_RECRUITING

Burlington, Vermont, 05401, United States
The Washington University
NOT_YET_RECRUITING

St Louis, Missouri, 63130, United States
Tohoku Medical and Pharmaceutical University Hospital
NOT_YET_RECRUITING

Sendai, Miyagi, 981-8558, Japan
Tokushima University Hospital
NOT_YET_RECRUITING

Tokushima, Tokuchima, 770-8503, Japan
Universitaetsklinikum Giessen und Marburg GmbH Standort Marburg
NOT_YET_RECRUITING

Marburg, Hesse, 35043, Germany
University General Hospital of Patras
NOT_YET_RECRUITING

Patras, Peloponnese, 26504, Greece
University of North Carolina (UNC)
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Ulm
NOT_YET_RECRUITING

Ulm, Baden-Wurttemberg, 89081, Germany
Universitätsklinikum Mannheim GmbH
NOT_YET_RECRUITING

Mannheim, Baden-Wurttemberg, 68167, Germany
Warszawski Uniwersytet Medyczny
NOT_YET_RECRUITING

Warsaw, Masovian Voivodeship, 02-097, Poland
Yale University School of Medicine
NOT_YET_RECRUITING

New Haven, Connecticut, 06510, United States

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