New hope for CIDP: modified immune protein enters human testing
NCT ID NCT06798012
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 study is testing TAK-411, a specially modified immune globulin, in 36 adults with CIDP, an autoimmune disease that attacks nerve insulation and causes muscle weakness. The main goal is to see if TAK-411 improves physical function over 24 weeks compared to historical placebo data. Participants receive infusions for up to a year and are followed for three more weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
TAK-411 (a modified immune globulin made from human plasma)
What this could lead to
If successful, TAK-411 could offer a new treatment option to improve physical function and reduce disability in people with CIDP.
What could go wrong
This is an early Phase 2 proof-of-concept study with only 36 participants, so results may not apply to everyone. The trial is open-label, meaning both patients and doctors know the treatment, which can bias results.
Disclaimer
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the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02215, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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California Pacific Medical Center
RECRUITINGSan Francisco, California, 94109, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fundacion Oftalmologica de Santander - FOSCAL
NOT_YET_RECRUITINGBucaramanga, 680001, Colombia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fundacion Valle del Lili
NOT_YET_RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospital Universitario San Ignacio
NOT_YET_RECRUITINGBogotá, D.C., Colombia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Houston Methodist Research Institute
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic Rochester
RECRUITINGRochester, Minnesota, 55905, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Neuro ClinicaS.A.S
NOT_YET_RECRUITINGMedellín, Antioquia, 50021, Colombia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn Blood Disorders Program - Hospital of The University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Curators of the University of Missouri on behalf of University of Missouri Health Care
RECRUITINGColumbia, Missouri, 65212-0001, United States
Contact Email: •••••@•••••
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The Washington University
RECRUITINGSt Louis, Missouri, 63110, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UF Health Neurology - Jacksonville
RECRUITINGJacksonville, Florida, 32209, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universidad del Rosario
NOT_YET_RECRUITINGBogotá, 111711, Colombia
Contact
Contact Email: •••••@•••••
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University Health Network
NOT_YET_RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Calgary
NOT_YET_RECRUITINGCalgary, Alberta, T2N 4Z6, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California San Diego
RECRUITINGLa Jolla, California, 92093, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of South Florida
RECRUITINGTampa, Florida, 33612, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Washington
RECRUITINGSeattle, Washington, 98195, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Visionary Investigators Network
RECRUITINGMiami, Florida, 33133, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••