New combo therapy aims to boost remission in hodgkin lymphoma

NCT ID NCT06831370

Recruiting now Disease control Sponsor: Takeda Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 4 study is testing the safety and effectiveness of brentuximab vedotin (Adcetris) combined with standard chemotherapy (doxorubicin, vinblastine, and dacarbazine) in 124 Indian adults with untreated stage 3 or 4 classical Hodgkin lymphoma. Participants will receive the treatment for about 6 months, with regular heart and lung checks. The goal is to see how well the combo works at achieving complete remission and to monitor any side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: brentuximab vedotin (Adcetris) plus doxorubicin, vinblastine, and dacarbazine
What this could lead to: If successful, this could confirm a safe and effective treatment option for advanced Hodgkin lymphoma in Indian patients, potentially improving remission rates.
What could go wrong: This is a single-arm, open-label study without a comparison group, so results may be less definitive. Side effects from chemotherapy and the targeted drug are possible, and the trial is limited to Indian patients, so findings may not apply broadly.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ACTREC
ACTIVE_NOT_RECRUITING

Navi Mumbai, Maharashtra, 410210, India
AIIMS
RECRUITING

New Delhi, 110029, India
DMH
ACTIVE_NOT_RECRUITING

Pune, Maharashtra, 411004, India
Gauhati Medical college and Hospital
ACTIVE_NOT_RECRUITING

Guwahati, Assam, 781032, India
HCG Cancer Centre
RECRUITING

Bangalore, Karnataka, 560027, India
HCG City Cancer Centre
RECRUITING

Vijayawada, Andhra Pradesh, 520002, India
HCG Manavata Cancer Centre
ACTIVE_NOT_RECRUITING

Nashik, Maharashtra, 422002, India
JIPMER
ACTIVE_NOT_RECRUITING

Puducherry, Kerala, 605006, India
NRS Medical college & Hospital, Kolkata
RECRUITING

Kolkata, West Bengal, 700014, India
Rajiv Gandhi Cancer Hospital
ACTIVE_NOT_RECRUITING

Delhi, New Delhi, 110085, India
Unique Hospital Multispeciality and Research Institute
RECRUITING

Surat, Gujarat, 395002, India

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