HODGKIN LYMPHOMA

This early-stage study tests a new type of cell therapy for people with certain lymphomas that have come back or not responded to treatment. The therapy uses immune cells from healthy donors that are modified to better recognize and attack cancer cells, plus an added molecule to …

This study tests a stem cell transplant using the patient's own cells to treat Hodgkin and non-Hodgkin lymphoma, including in people with HIV. The goal is to see if a radiation-free preparation before transplant can improve survival and reduce side effects. About 150 participants…

This program provides an experimental drug called AVM0703 to people with various cancers, including brain tumors, breast cancer, and leukemia. It is available in the US when a doctor requests it. So far, 37 patients have received the treatment, and side effects have been mostly m…

This study tests whether two newer drugs (pembrolizumab and brentuximab vedotin) can shrink or eliminate Hodgkin lymphoma that has returned or not responded to initial treatment. About 84 adults will receive either the new drug combo or standard chemotherapy, followed by high-dos…

This study tests a combination of four drugs (mosunetuzumab, polatuzumab, tafasitamab, and lenalidomide) in people with relapsed B-cell lymphoma that has not responded to prior treatments. The goal is to see if this mix can shrink tumors or stop the cancer from growing. About 36 …

This study tests a new drug called CTX-8371 in people with advanced cancers that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 85 adults with certain types of lung, breast, lymphoma, head and neck, or skin can…

This study tests a new oral drug called AZD3470 in people with certain blood cancers, including Hodgkin and non-Hodgkin lymphoma. The goal is to see if the drug is safe and works, either alone or with other cancer treatments. About 161 adults and adolescents will take part in thi…

This study tests whether a cord blood transplant, used as a first or second transplant, can help children and young adults (up to age 26) with blood cancers like leukemia and lymphoma. About 71 participants will receive the transplant to see if it keeps them cancer-free for at le…

This study tests a new treatment for advanced Hodgkin lymphoma that combines the immunotherapy drug nivolumab with chemotherapy. Doctors use PET scans during treatment to see how well it's working and adjust therapy accordingly. The goal is to improve outcomes while reducing side…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests a new approach to collecting stem cells for transplant in people with multiple myeloma, Hodgkin lymphoma, or non-Hodgkin lymphoma. The goal is to see if using a standard drug alone, with a second drug only when needed, can collect enough stem cells while possibly…

This study tests a combination of two drugs, nivolumab and ruxolitinib, in people with classical Hodgkin lymphoma that has returned or not responded to prior treatments. The goal is to find the safest dose of ruxolitinib when given with nivolumab and to see how well the combinati…

This study is for people with Hodgkin lymphoma that has come back or not responded to treatment. After a stem cell transplant, participants will receive a drug called a PD-1 inhibitor to help keep the cancer from returning. The goal is to see if this maintenance therapy improves …

This study tests a new treatment for people with blood cancers like leukemia, lymphoma, or multiple myeloma that have come back or not responded to standard therapy. Participants receive donor immune cells (NK cells) that are engineered to better target cancer, along with chemoth…

This study tests whether a drug called BV (brentuximab vedotin) combined with standard chemotherapy (AVD) works better than chemotherapy alone for people with newly diagnosed, early stage bulky Hodgkin lymphoma. BV targets and kills cancer cells with a specific marker (CD30), whi…

This study tests three different drug combinations to prevent graft-versus-host disease (GVHD) in 400 people with blood cancers receiving stem cells from unrelated donors. GVHD is a serious complication where donor cells attack the patient's body. The goal is to find which approa…

This study tests a two-step, lower-intensity approach using radiation and chemotherapy before a stem cell transplant for people with various blood cancers or disorders. The goal is to see if this gentler preparation reduces the risk of death from the transplant itself. About 63 p…

This study is for adults in India with untreated stage 3 or 4 Hodgkin lymphoma. It tests a drug called brentuximab vedotin combined with standard chemotherapy (AVD) to see how safe and effective it is. Participants receive treatment for about 6 months and are monitored for side e…

This study tests a new form of the chemotherapy drug carmustine (called VI-0609) that doesn't contain ethanol, compared to the standard version (BiCNU) which does. Both are used as part of the BEAM conditioning regimen before a stem cell transplant in adults with Hodgkin or non-H…

This study is for people with certain blood cancers, like leukemia or lymphoma. It tests a stem cell transplant from a half-matched donor, using a special drug combo (treosulfan and fludarabine) plus low-dose radiation to prepare the body. The goal is to see if this approach help…

This study looks at how well the drug brentuximab vedotin (BV) works for adults with Hodgkin's lymphoma who have had a stem cell transplant. The goal is to see if BV can help prevent the cancer from coming back. About 70 participants will receive BV as part of their regular care …

This study tests a new treatment for Hodgkin lymphoma that has returned or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to recognize and attack cancer cells carrying a protein called CD30. About 31 participants will receive…

This phase 3 trial compares two chemotherapy combinations (ABVD and A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. About 1,042 participants will receive 3-4 cycles of chemo, with a PET scan after 2 cycles to tailor further treatment. The goal is to see which…

This study gives people with blood cancers, immune disorders, and other serious diseases access to unlicensed cord blood units for transplant. It includes both children and adults of any age. The main goal is to see how well the body recovers its white blood cells after the trans…

This study tracks side effects in children and teenagers with untreated Hodgkin lymphoma who receive ADCETRIS along with standard chemotherapy (AVD). Researchers will monitor for serious side effects like low blood counts, nerve damage, and lung problems over 26 weeks. The goal i…

This study tests a drug called tislelizumab as a first treatment for adults with Hodgkin lymphoma who cannot receive standard chemotherapy due to age or other health issues. The goal is to see if the drug can shrink or control the cancer. About 28 participants will take part in t…

This study tests a shorter course of a drug combination called BrECADD for people with advanced Hodgkin lymphoma (stage 2B to IV). About 48 adults aged 18 to 60 will receive this treatment to see if it works well and is tolerable. Researchers will also check if a blood test for t…

This early-stage study tests a new type of stem cell transplant for children whose blood cancers or solid tumors have come back or are hard to treat. Doctors use a special method to remove certain immune cells from the donor's stem cells and give a drug called zoledronate after t…

This study tests whether adding the drug pembrolizumab to standard chemotherapy (GVD) can help people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive the combination, and those who respond well may go on to a stem…

This study compares two first-line treatments for advanced Hodgkin lymphoma. One group gets the immunotherapy drug nivolumab combined with chemotherapy (AVD), while the other receives standard chemotherapy (BEACOPP-like). The goal is to see which approach is safer and more effect…

This study is for people with certain types of lymphoma (B-cell or Hodgkin) that have come back or not responded well to treatment. Participants first receive a stem cell transplant using their own cells, then if their disease is stable or better, they get up to 8 doses of a targ…

This early-stage trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV), a common and dangerous infection after transplant. About 46 people with various blood cancers or disorders will take part. The g…

This study tests a vaccine (CMV-MVA Triplex) given to stem cell donors to help prevent CMV infection in patients receiving a stem cell transplant. The vaccine boosts the donor's immunity against CMV, which is then passed to the patient through the transplant. About 216 donor-reci…

This study looks at whether a 12-week high intensity interval training (HIIT) program is doable for young people who finished Hodgkin lymphoma treatment within the last two years. About 20 survivors aged 10 to 25 will try the program to see if it improves their heart and lung fit…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether a tailored physical activity program can help preserve exercise capacity, heart function, memory, and quality of life in adults (ages 18-85) with Hodgkin or non-Hodgkin lymphoma or stage I-III breast cancer who are undergoing chemotherapy or other cardiot…

This study looks at whether a Mediterranean diet and exercise program can help lymphoma patients finish their chemotherapy with fewer side effects. About 140 adults with untreated Hodgkin or Non-Hodgkin lymphoma will take part. The goal is to see if this lifestyle approach improv…

This study aims to find genetic markers that make some women more likely to experience early menopause after chemotherapy for breast cancer or Hodgkin lymphoma. Researchers will analyze stored ovarian tissue from 50 women who had fertility preservation before treatment. The goal …

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…

This research study aims to discover new genes that may cause cancer to run in families. Researchers will collect blood samples and health information from 1,500 people in families where multiple members have had childhood cancers. Participants will not receive direct treatment o…

This study looks at how certain blood cell changes (called clonal hematopoiesis) after Hodgkin lymphoma treatment might be linked to heart problems later in life. Researchers will check blood samples from 190 survivors who had chemotherapy as children or teens. The goal is to fin…

This study looks at how social and genetic factors affect the long-term health of young adults who survived Hodgkin or non-Hodgkin lymphoma. Researchers will collect blood samples and health information from 2000 survivors to understand why some have more health problems after tr…

This study looks at how the bodies of children and young adults (ages 6-25) with Hodgkin or non-Hodgkin lymphoma process certain drugs. Researchers will give small doses of probe medications during regular hospital visits and take blood samples to measure how the drugs are broken…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid for children and young adults with blood cancers like leukemia or lymphoma. About 30 participants who already take venetoclax this way will have their blood levels measured. T…