New drug combo aims to reduce deadly transplant complication

NCT ID NCT06615050

Recruiting now Disease control Sponsor: Incyte Corporation Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 14, 2026 · Updated 30 times

Summary

This study tests whether a new combination of drugs (tacrolimus, methotrexate, and ruxolitinib) works better than the standard combination (cyclophosphamide, tacrolimus, and mycophenolate) at preventing graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD is a serious condition where donor cells attack the patient's body. The trial involves 572 adults and will measure how long patients live without severe GVHD or death. Participants will be randomly assigned to one of the two drug regimens.

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Contacts and locations

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Study contacts

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Locations

Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
Blood and Marrow Transplant Group of Georgia
RECRUITING

Atlanta, Georgia, 30342, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Dana Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Duke University Medical Center
RECRUITING

Durham, North Carolina, 27705, United States
Fred Hutchinson Cancer Research Center
RECRUITING

Seattle, Washington, 98109, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Indiana University Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Karmanos Cancer Institute
RECRUITING

Detroit, Michigan, 48201, United States
Levine Cancer Institute
RECRUITING

Charlotte, North Carolina, 28204, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Memorial Sloan Kettering
RECRUITING

New York, New York, 10065, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Sarah Cannon
RECRUITING

Nashville, Tennessee, 37203, United States
Stanford Cancer Center
RECRUITING

Palo Alto, California, 94304, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94158, United States
University of Kansas Hospital Authority
RECRUITING

Kansas City, Kansas, 66160, United States
University of Miami
RECRUITING

Miami, Florida, 33136, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
University of North Carolina At Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53705, United States
Vanderbilt Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University, North Hospital
RECRUITING

Richmond, Virginia, 23298, United States
Washington University
RECRUITING

St Louis, Missouri, 63110, United States

Conditions

Explore the condition pages connected to this study.

GRAFT-VERSUS-HOST DISEASE (GVHD)