Can a Triple-Drug combo wipe out Slow-Growing lymphomas?
NCT ID NCT06792825
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether adding tafasitamab to the standard combination of lenalidomide and rituximab can improve complete responses in people with untreated follicular lymphoma or marginal zone lymphoma. Participants receive the three-drug regimen for about a year, and researchers will measure how many achieve a complete response at the end of treatment. The study enrolls adults who need treatment but have not yet received any systemic therapy for their lymphoma.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- tafasitamab combined with lenalidomide and rituximab
- What this could lead to
- If successful, this combination could become a new first-line treatment option for people with these slow-growing lymphomas, potentially improving complete response rates.
- What could go wrong
- This is an early-phase trial with a modest number of participants, so results may not hold up in larger studies. Side effects from the drug combination are possible, and not all patients may respond.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for FOLLICULAR LYMPHOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Masonic Cancer Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Engineered immune cells take aim at Hard-to-Treat lymphomas
- Can a targeted pill boost Chemotherapy's punch against lymphoma?
- Can donor immune cells be engineered to fight blood cancer?
- Can a simple blood test spot lymphoma earlier?
- Can a targeted drug beat radiation for early-stage lymphoma?
- Can a targeted drug boost standard therapy for a rare lymphoma?