Can a Triple-Drug combo wipe out Slow-Growing lymphomas?

NCT ID NCT06792825

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether adding tafasitamab to the standard combination of lenalidomide and rituximab can improve complete responses in people with untreated follicular lymphoma or marginal zone lymphoma. Participants receive the three-drug regimen for about a year, and researchers will measure how many achieve a complete response at the end of treatment. The study enrolls adults who need treatment but have not yet received any systemic therapy for their lymphoma.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tafasitamab combined with lenalidomide and rituximab
What this could lead to
If successful, this combination could become a new first-line treatment option for people with these slow-growing lymphomas, potentially improving complete response rates.
What could go wrong
This is an early-phase trial with a modest number of participants, so results may not hold up in larger studies. Side effects from the drug combination are possible, and not all patients may respond.

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Conditions

The condition(s) this trial relates to.

follicular lymphoma Lymphoma, B-Cell, Marginal Zone marginal zone lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Masonic Cancer Center

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

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