Masonic Cancer Center, University Of Minnesota

This study tests a special stem cell transplant that removes certain immune cells to lower the risk of graft-versus-host disease (GVHD) and reduce the need for long-term immune-suppressing drugs. It is for people with inherited bone marrow failure disorders like Fanconi anemia. T…

This early-phase study tests a new approach called peptide alarm therapy (PAT) given as an injection directly into tumors, along with a standard immunotherapy drug, for people with advanced solid tumors that have stopped responding to at least one prior treatment. The goal is to …

This study tests a stem cell transplant using the patient's own cells to treat Hodgkin and non-Hodgkin lymphoma, including in people with HIV. The goal is to see if a radiation-free preparation before transplant can improve survival and reduce side effects. About 150 participants…

This study tests a new way to prepare stem cells for transplant in children and adults with blood cancers like leukemia. The method removes certain immune cells to lower the risk of graft-versus-host disease, a serious side effect. About 70 participants will receive the treatment…

This study tests whether adding a special gut bacteria therapy (RMT) to standard immunotherapy and chemotherapy can help control advanced lung cancer better than placebo. About 82 people with untreated, advanced non-small cell lung cancer will take RMT or placebo pills along with…

This study tests a stem cell transplant approach for people with blood cancers like AML and MDS. It uses milder chemotherapy (treosulfan and fludarabine) followed by a donor stem cell infusion, plus drugs to prevent graft-versus-host disease. The goal is to improve survival at 10…

This early-phase study tests a new drug called FT536 for adults with a fast-growing brain tumor (WHO grade 4 astrocytoma) that has come back after standard treatment. The drug is injected directly into the tumor during surgery. The main goal is to check safety and find the right …

This study uses a cord blood transplant after strong chemotherapy and radiation to treat various blood cancers like leukemia and lymphoma. About 200 participants will receive the transplant to see if it improves survival one year later. The approach aims to replace diseased bone …

This study tests a stem cell transplant from a donor to treat people with severe blood disorders like sickle cell disease and thalassemia. About 62 participants will receive the transplant and be monitored for side effects like graft-versus-host disease. The goal is to control th…

This study tests a two-step treatment for children and young adults with high-risk neuroblastoma. After initial chemotherapy, participants receive two rounds of very strong chemo, each followed by an infusion of their own stem cells to help the body recover. The goal is to see if…

This study tests a treatment for people whose stem cell transplant (for blood cancers or other diseases) fails to take hold. The approach uses chemotherapy and low-dose radiation to prepare the body for a second infusion of donor stem cells, usually from a half-matched family don…

This early-phase study tests a new drug called GTB-5550 in adults with advanced solid tumors that have not responded to prior treatments. The drug is designed to bridge natural killer cells to cancer cells, helping the immune system attack the tumor. The main goal is to find the …

This early-stage trial tests whether injecting lab-grown muscle cells into the feet of adults with Duchenne muscular dystrophy is safe. Only 8 non-ambulatory participants will receive the cells, and researchers will monitor for side effects and immune reactions. The goal is to fi…

This early-phase study tests a specially modified virus that is injected directly into pancreatic tumors during an endoscopic procedure. The goal is to find the safest dose and see if the virus can attack cancer cells without harming healthy tissue. The trial enrolls 18 adults wi…

This study tests whether offering free legal services to people caring for someone with advanced colorectal cancer can reduce their stress and improve their finances and well-being. About 20 patient-caregiver pairs will receive personalized legal help from a nonprofit organizatio…

This study tests if a nerve block using long-lasting numbing medicine works as well as an epidural for pain after pancreatic surgery. About 78 adults having this surgery will be randomly assigned to one of the two methods. The goal is to see if the nerve block provides similar pa…

This study aims to see if unlicensed umbilical cord blood units are safe to use for cell therapy in people with blood cancers or lymphatic diseases. Up to 250 participants will receive an infusion of these cells. The main goal is to check for any infections or serious reactions f…

This study looks at how much harmful chemicals firefighters are exposed to when fighting structural fires. Researchers will collect urine and cheek cell samples from 60 firefighters before and after a fire call. The goal is to measure changes in biomarker levels to better underst…

This study is building a national registry of people with adrenoleukodystrophy (ALD) and their family members. Researchers will collect medical records and survey data every six months to understand how the disease progresses and to find biological markers. No treatment is given;…

This study looks at what happens when smokers relight cigarettes instead of smoking them all at once. Researchers will measure chemicals in the smoke and how people puff. The goal is to see if relit cigarettes produce more harmful substances. The study involves 30 smokers who alr…

This study is for people aged 8 to 25 who have survived a heart transplant, childhood leukemia, or were born with chronic lung disease (BPD). Researchers want to measure how the heart and lungs work during exercise using special breathing tests. The goal is to better understand w…

This study tests a tool kit called SALSA that tracks stress, mood, and speech to catch thinking problems early in people getting CAR-T therapy for cancer. About 38 adults will use the tool during their hospital stay. The goal is to see if it's practical and better than the usual …