Masonic Cancer Center, University Of Minnesota

This study tests a stem cell transplant (bone marrow transplant) for people with severe immune system problems, like SCID (bubble boy disease) and Wiskott-Aldrich syndrome. The goal is to replace the faulty immune system with healthy donor cells. 57 participants will be followed …

This study tests a new stem cell treatment called MGTA-456 for people with high-risk blood cancers like leukemia and lymphoma. The treatment uses a special process to grow more stem cells from donated umbilical cord blood before transplant. The goal is to help the body rebuild he…

This study tests FDA-approved CAR-T cell therapy in 150 children and adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia or large B-cell lymphoma. Participants receive immune cells that are modified to recognize and attack cancer cells. The main goals are to…

This early-stage trial tests a new treatment called FT536 for people with ovarian, fallopian tube, or primary peritoneal cancer that has returned after prior therapy. The treatment is given directly into the abdomen three times in one week, after a short course of chemotherapy to…

This study tests whether adding a drug called E7777 before standard CAR-T cell therapy can help people with relapsed or hard-to-treat large B-cell lymphoma. About 30 adults will receive E7777 followed by chemotherapy and an approved CAR-T product. The goal is to find the safest d…

This study tests a stem cell transplant method for people with inherited metabolic disorders and severe osteopetrosis. The goal is to get donor cells to grow in the patient's body while keeping transplant-related deaths low. Participants receive chemotherapy drugs (busulfan and f…

This study tests whether giving two drugs—simvastatin (a cholesterol pill) and dexamethasone (a steroid injected into the spine)—can safely prevent or reduce brain-related side effects from a powerful lymphoma cell therapy called axi-cel. About 37 adults with certain types of B-c…

This study looks at whether kava, a plant used for relaxation, can safely reduce anxiety and stress in people who have finished cancer treatment. About 43 survivors of breast, gynecologic, lung, or head/neck cancer will take either kava or a placebo for 14 days, then switch after…

This early-phase study tests whether taking curcumin (from turmeric) and a special olive oil rich in healthy compounds can safely help adults with NF1 who have skin tumors. About 23 participants take these supplements twice daily for up to 12 months. The main goal is to check for…

This study watches how the drug laronidase behaves in the body of children with a rare disease called MPS IH before and after they get a stem cell transplant. Researchers will take blood samples from 13 children up to 3 years old to see what affects drug levels. The goal is to le…

This study looks at the 'time toxicity' of cancer—how much time people with advanced breast or ovarian cancer spend on care tasks like appointments, travel, and managing symptoms. About 80 participants will use a smartphone app for 28 days to track their activities and daily well…

This study looks at how nornicotine, a chemical found in smokeless tobacco, turns into a cancer-causing substance called NNN inside the body. Researchers will measure this process in 55 adult smokeless tobacco users. The goal is to understand the risk and help regulators decide w…

This study looks at what happens to chemicals in the body when smokers switch to a special research e-cigarette. About 47 adult smokers who smoke at least 5 cigarettes daily will use the e-cigarette for a period. Researchers will measure nicotine and other harmful substances in u…