PET-Guided chemotherapy trial aims to improve hodgkin lymphoma treatment

NCT ID NCT04685616

Recruiting now Disease control Sponsor: University College, London Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 09, 2026 · Updated 2 times

Summary

This phase 3 trial compares two chemotherapy combinations (ABVD and A2VD) for people with newly diagnosed, early-stage Hodgkin lymphoma. About 1,042 participants will receive 3-4 cycles of chemo, with a PET scan after 2 cycles to tailor further treatment. The goal is to see which regimen better prevents the cancer from returning, while reducing side effects.

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Conditions

The condition(s) this trial relates to.

classic Hodgkin lymphoma Hodgkins lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN LYMPHOMA

Contacts and locations

Locations

AZ Delta Campus Rumbeke
RECRUITING

Roeselare, West Flanders, Deltalaan 1, 8800, Belgium
Aarhus University Hospitak Skjeby
RECRUITING

Aarhus, Denmark
Aberdeen Royal Infirmary
RECRUITING

Aberdeen, AB25 2ZN, United Kingdom
Amsterdam UMC - location VUMC
RECRUITING

Amsterdam, 1081 HV, Netherlands
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, G12 0YN, United Kingdom
Blackpool Victoria Hospital
RECRUITING

Blackpool, Lancashire, FY3 8NR, United Kingdom
Box Hill Hospital
RECRUITING

Box Hill, VIC 3128, Australia
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, United Kingdom
CHU-UCL Namur
RECRUITING

Namur, Belgium
CancerCare Manitoba
RECRUITING

Winnipeg, R3E 0V9, Canada
Castle Hill Hospital
RECRUITING

Hull, HU16 5JQ, United Kingdom
Christie Hospital
RECRUITING

Manchester, M20 4BX, United Kingdom
Churchill Hospital
RECRUITING

Oxford, OX3 7LE, United Kingdom
Colchester Hospital, ESNEFT
RECRUITING

Colchester, CO4 5JL, United Kingdom
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, Spain
Concord Repatriation General Hospital
RECRUITING

Sydney, NSW 2139, Australia
Derriford Hospital
RECRUITING

Plymouth, PL6 8DH, United Kingdom
Freeman Hospital, Newcastle
RECRUITING

Newcastle upon Tyne, Newcastle, NE7 7DN, United Kingdom
Glan Clwyd Hospital
RECRUITING

Bodelwyddan, LL18 5UJ, United Kingdom
Hampshire Hospitals NHS Foundation Trust
RECRUITING

Basingstoke, Hampshire, RG24 9NA, United Kingdom
Hospital Del Mar
RECRUITING

Barcelona, ES 08003, Spain
Institut Catala d'Oncologia
RECRUITING

Barcelona, ES 08908, Spain
Instituto Portugues de Oncologia de Lisboa Francisco Gentil
RECRUITING

Lisbon, Portugal
Juravinski Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 5C2, Canada
Lanarkshire
RECRUITING

Glasgow, Scotland, G71 8BB, United Kingdom
Liverpool Hospital
RECRUITING

Liverpool, Australia
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
NL 331 - Haaglanden Medisch Centrum (HMC) - Haaglanden MC
RECRUITING

The Hague, Netherlands
Narodny Onkologicky Ustav
RECRUITING

Bratislava, Slovakia
Norfolk & Norwich University Hospital
RECRUITING

Norwich, NR4 7UY, United Kingdom
Nottingham University Hospitals NHST
RECRUITING

Nottingham, NG51PB, United Kingdom
Ottowa Hospital Research Institute
RECRUITING

Ottawa, K1Y 4E9, Canada
QEII Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 3A7, Canada
Radboud University Medical Center Nijmegen
RECRUITING

Nijmegen, Netherlands
Reinier de Graafweg 3-11 - Postbus 5011 - 2625 AD Delft
RECRUITING

Delft, Netherlands
Rigshospitalet
RECRUITING

Copenhagen, Denmark
Royal Adelaide Hospital
RECRUITING

Adelaide, 5000, Australia
Royal Brisbane and Women's Hospital
RECRUITING

Brisbane, QLD 4006, Australia
Royal Cornwall Hospital
RECRUITING

Truro, TR1 3LJ, United Kingdom
Royal Darwin Hospital
RECRUITING

Darwin, NT 0810, Australia
Royal Hallamshire Hospital
RECRUITING

Sheffield, S10 2JF, United Kingdom
Royal Marsden Hospital
RECRUITING

Sutton, SM2 5PT, United Kingdom
Royal Marsden Hospital Chelsea
RECRUITING

London, SW3 6JZ, United Kingdom
Royal North Shore Hospital
RECRUITING

Saint Leonards, New South Wales, 2065, Australia
Saint John Regional Hospital
RECRUITING

Saint John, E2L 4L2, Canada
Southampton General Hospital
RECRUITING

Southampton, SO16 6YD, United Kingdom
St Bartholomew's Hospital
RECRUITING

London, EC1A 7BE, United Kingdom
St George Hospital
RECRUITING

Sydney, NSW 2217, Australia
St George's Hospital
RECRUITING

London, Tooting, SW17 0QT, United Kingdom
St James University Hospital
RECRUITING

Leeds, LS9 7TF, United Kingdom
St James's Hospital
RECRUITING

Dublin, Ireland
St. Vincent's University Hospital
RECRUITING

Dublin, Ireland
Stanford University - (Stanford Cancer Institute)
RECRUITING

Stanford, California, 94305, United States
Sunderland Royal Hospital
RECRUITING

Sunderland, SR4 7TP, United Kingdom
Sunshine Hospital (Western Health)
RECRUITING

Melbourne, VIC 3021, Australia
The Clatterbridge Cancer Centre NHSFT, 65 Pembroke Place
RECRUITING

Liverpool, L7 8YA, United Kingdom
Torbay Hospital
RECRUITING

Torquay, TQ2 7AA, United Kingdom
Townsville University Hospital
RECRUITING

Townsville, Queensland, QLD 4814, Australia
UZ Leuven
RECRUITING

Leuven, Belgium
Universitair Medisch Centrum Groningen
RECRUITING

Groningen, Netherlands
Universitair Ziekenhuis Antwerpen
RECRUITING

Antwerp, Belgium
University College London Hospitals NHS Foundation Trust (UCLH)
RECRUITING

London, NW1 2BU, United Kingdom
University Health Network Princess Margaret Cancer Centre
RECRUITING

Toronto, M5G 2M9, Canada
University Hospital Coventry
RECRUITING

Coventry, CV2 2DX, United Kingdom
University Hospital Galway
RECRUITING

Galway, Ireland
University Hospital of Wales, Cardiff & Vale University Local Health Board
RECRUITING

Cardiff, CF14 4XW, United Kingdom
University Hospitals Birmingham
RECRUITING

Birmingham, B15 2GW, United Kingdom
University Hospitals of Leicester NHS Trust
RECRUITING

Leicester, LE1 5WW, United Kingdom
University of Miami School of Medicine
RECRUITING

Miami, Florida, 33136, United States
Vancouver Cancer Centre
RECRUITING

Vancouver, V5Z 4E6, Canada
Ziekenhuis Netwerk Antwerpen
RECRUITING

Antwerp, Belgium

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