Donor vaccine aims to shield transplant patients from common virus

NCT ID NCT06059391

Recruiting now Prevention Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tests a vaccine called CMV-MVA Triplex, given to stem cell donors before they donate. The goal is to boost the donor's immunity against cytomegalovirus (CMV), which can then be passed to the transplant patient. Researchers hope this will prevent CMV infection in the 216 patients receiving stem cell transplants for blood cancers or other blood disorders.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CMV-MVA Triplex vaccine
What this could lead to: If it works, this vaccine could help prevent dangerous CMV infections in stem cell transplant patients by boosting donor immunity.
What could go wrong: This is a phase 2 trial, so it is still early. The vaccine may not provide enough protection, and there are risks like graft-versus-host disease or side effects from the vaccine.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia acute myeloid leukemia B-cell chronic lymphocytic leukemia chronic myelogenous leukemia, BCR-ABL1 positive hematopoietic and lymphoid system neoplasm Hodgkins lymphoma Leukemia, Myelogenous, Chronic, BCR-ABL Positive myelodysplastic syndrome Myelodysplastic Syndromes myelofibrosis Myeloproliferative Disorders myeloproliferative neoplasm non-Hodgkin lymphoma Precursor Cell Lymphoblastic Leukemia-Lymphoma primary myelofibrosis cytomegalovirus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA ACUTE MYELOID LEUKEMIA CHRONIC LYMPHOCYTIC LEUKEMIA CHRONIC MYELOID LEUKEMIA, BCR-ABL1 POSITIVE HEMATOPOIETIC AND LYMPHOID SYSTEM NEOPLASM HODGKIN LYMPHOMA MYELODYSPLASTIC SYNDROME MYELOFIBROSIS MYELOPROLIFERATIVE NEOPLASM NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

City of Hope Medical Center
RECRUITING

Duarte, California, 91010, United States
DFCI/BWH Brigham and Women's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Northside Hospital
RECRUITING

Atlanta, Georgia, 30342, United States

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