HEMATOPOIETIC AND LYMPHOID SYSTEM NEOPLASM

This study tests a combination of two or three drugs (ivosidenib, venetoclax, with or without azacitidine) in people with certain blood cancers that have an IDH1 mutation. The goal is to find the best dose and see how well the drugs control the cancer. About 96 adults with acute …

This study is for people with certain blood cancers (like CLL or lymphoma) who are starting a type of targeted drug called a BTK inhibitor. These drugs can raise blood pressure and increase the risk of heart problems. The study will test whether carefully managing any new or wors…

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in 25 blood cancer patients receiving a stem cell transplant. GVHD occurs when donor cells attack the patient's body. The approach combin…

This study tests a low-intensity vibration board in 75 adults with blood cancers who are planning a stem cell transplant or cell therapy. The vibrations may help maintain bone density and boost immune cell activity. Researchers will measure how often patients use the board and wh…

This study tests a vaccine (CMV-MVA Triplex) given to stem cell donors to help prevent CMV infection in patients receiving a stem cell transplant. The vaccine boosts the donor's immunity against CMV, which is then passed to the patient through the transplant. About 216 donor-reci…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with …

This study looks at whether a spinal cord stimulator can help people with long-term nerve pain caused by chemotherapy. About 20 adults who still have pain at least six months after finishing chemo will try this device. The goal is to see if it cuts pain by half or more and improv…

This study tests a home-based exercise program for underserved cancer survivors and their caregivers. Participants will receive tailored workouts through the YMCA to help improve physical function and quality of life. The goal is to see if this approach is practical and acceptabl…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study compares giving cancer treatment at home versus in a clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves the overall experience. About 220 participants will be randomly assigned to receive their t…

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study looks at how patients and doctors discuss immunotherapy, a type of cancer treatment. Researchers want to find out where patients get their information, what they understand, and how doctors explain it. They will also test if educational videos help patients learn more …

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study aims to find normal levels for a new blood and urine test that might one day help screen for cancer. Researchers at Mayo Clinic will collect samples from 10,000 people without cancer to establish a baseline. The goal is to improve early detection, not to treat or cure …

This study looks at a new way to help family members of cancer patients learn about their own inherited cancer risk. Instead of relying on the patient to share genetic test results, doctors will directly contact at-risk relatives to offer genetic counseling and testing. The goal …

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers aim to build a biobank to improve cancer prevention, early detection, and treatment. Participants must have a con…

This study looks at whether a special health check-up for older adults with cancer, done over video, can find their weak spots and guide their care. It involves 216 people aged 65 and older starting new cancer treatment. The goal is to see if this approach helps patients complete…

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend weekly group meetings led by social workers and complete surveys about their quality of life and me…