HEMATOPOIETIC AND LYMPHOID SYSTEM NEOPLASM

This study tests a combination of three drugs—ivosidenib, venetoclax, and azacitidine—in people with blood cancers like acute myeloid leukemia (AML) that have a specific IDH1 mutation. The goal is to see if the combo is safe and works better than current treatments. About 96 adul…

This study at Mayo Clinic looks at how often high blood pressure happens in patients with certain blood cancers (like CLL or lymphoma) who are taking a type of targeted drug called a BTK inhibitor. It will track 100 patients over a year to see if managing blood pressure well can …

This study tests the safety and best dose of bendamustine, given with or without cyclophosphamide, to prevent graft-versus-host disease (GVHD) in people with blood cancers receiving a stem cell transplant. About 25 participants will receive the drug after transplant, along with s…

This study tests whether low-intensity mechanical stimulation (LIMS) vibration therapy can help blood cancer patients who are about to receive a stem cell transplant or cell therapy. The vibration board sends gentle waves through the bones, which may stimulate bone growth, improv…

This study aims to find normal values for a new blood and urine test that might detect cancer early. Researchers at Mayo Clinic will collect samples from 10,000 adults without known cancer and review their medical records. The goal is to set a baseline for future cancer screening…

This phase 2 trial tests a vaccine called CMV-MVA Triplex, given to stem cell donors before they donate. The goal is to boost the donor's immunity against cytomegalovirus (CMV), which can then be passed to the transplant patient. Researchers hope this will prevent CMV infection i…

This study tests whether group sessions that teach stress management skills can lower distress in people with cancer. About 400 adults with cancer who have moderate distress will take part. The program helps patients recognize and reduce stress in their daily lives.

This study tests whether virtual group therapy based on Acceptance and Commitment Therapy (ACT) and compassion practices can improve psychological well-being in cancer patients. Researchers at Mayo Clinic will enroll 200 adults with cancer who are experiencing stress. Participant…

This study compares giving cancer treatment at home versus in the clinic for people with advanced cancers. The goal is to see if home treatment reduces stress, financial burden, and improves overall experience. About 220 participants will be randomly assigned to receive their reg…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain control and lower the risk of opioid misuse. About 660 adults with cancer-rel…

This pilot study at Mayo Clinic is testing whether a single 20-30 minute virtual reality session can safely reduce anxiety, depression, and fatigue in cancer patients. 24 adults undergoing chemotherapy or bone marrow transplant will try calming VR experiences like nature walks or…

This study tests whether spinal cord stimulation (SCS) can reduce pain and improve quality of life in people with chemotherapy-induced peripheral neuropathy (CIPN). CIPN causes numbness, tingling, and pain, often in the hands and feet. Researchers will follow 20 adults who have h…

This study offers a home-based exercise program for underserved cancer survivors and their caregivers. The goal is to see if this program helps improve physical function and quality of life. Participants will follow tailored exercise videos for 12 weeks. The study aims to make su…

This study looks at DNA and protein changes in tumor samples from 50 adults with aggressive or metastatic cancer. Researchers aim to find new markers for diagnosis and potential drugs. Participants provide blood, cheek swabs, and tissue from standard biopsies or surgeries.

This study tests a program called CUSP2CT, designed to increase the number of racial and ethnic minorities referred to and enrolled in cancer clinical trials. The program involves educational sessions, discussions, and patient navigation. Researchers will track changes in referra…

This study looks at how patients and doctors discuss immunotherapy, a type of cancer treatment. Researchers want to find out where patients get their information, what they understand, and how doctors explain it. They will also test if educational videos can help patients learn m…

This study aims to find markers and causes of cancer by analyzing participants' DNA, RNA, and tissue samples. Researchers will use this information to improve cancer prevention, early detection, and treatment. The study will enroll 500 adults with cancer at Mayo Clinic.

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. About 60 participants will join group sessions led by social workers. The goal is to see if the program improves quality of …

This study offers free genetic testing to the general public to identify people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers aim to see if broad testing is more effective than only testing those with a family history. Up…

This study looks at a new way to help family members of cancer patients learn if they have inherited a higher risk for cancer. About 240 people with a known cancer gene change will be asked to share their test results with their close relatives, either on their own or with help f…

This study looks at whether a special health check-up done over video (telemedicine) can help find weak spots in older adults with cancer and guide their care. It includes 216 people aged 65 and older with cancer who are starting a new treatment. The goal is to see if this approa…