Free genetic testing offered to 27,500 people to find hidden cancer risks

NCT ID NCT04494945

Recruiting now Knowledge-focused Sponsor: OHSU Knight Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times

Summary

This study offers free genetic testing to the general public to identify people with inherited cancer syndromes like hereditary breast and ovarian cancer or Lynch syndrome. Researchers aim to see if broad testing is more effective than only testing those with a family history. Up to 27,500 adults will provide saliva samples and complete surveys, with genetic counseling for those who test positive.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: genetic testing
What this could lead to: If successful, this could show that broad public genetic testing is effective and cost-efficient for identifying cancer risks, leading to wider screening programs.
What could go wrong: This is an observational study, not a treatment trial. It may not prove that testing improves health outcomes, and results depend on participants following up with recommended care.

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Conditions

The condition(s) this trial relates to.

cancer Colorectal Neoplasms, Hereditary Nonpolyposis ductal breast carcinoma in situ hematopoietic and lymphoid system neoplasm hereditary breast ovarian cancer syndrome hereditary neoplastic syndrome Lynch syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRCA1/2-ASSOCIATED HEREDITARY BREAST AND OVARIAN CANCER SYNDROME BREAST DUCTAL CARCINOMA IN SITU HEMATOPOIETIC AND LYMPHOID SYSTEM NEOPLASM HEREDITARY NEOPLASTIC SYNDROME LYNCH SYNDROME MALIGNANT SOLID NEOPLASM

Contacts and locations

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Locations

OHSU Knight Cancer Institute
RECRUITING

Portland, Oregon, 97239, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact
Providence Portland Medical Center
RECRUITING

Portland, Oregon, 97213, United States

Contact Email: •••••@•••••

Contact

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