MALIGNANT SOLID NEOPLASM

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study looks at whether giving focused radiation before or after surgery works better for people with cancer that has spread to the brain. About 140 adults who need surgery for a brain tumor will be randomly assigned to receive stereotactic radiosurgery either before or after…

This study tests a new way to deliver radiation therapy for people with lung cancer, melanoma, or kidney cancer that has started to grow in a few new spots while on other treatments. The approach uses a PET scan to find the most active parts of the tumor and deliver a higher radi…

This study tests whether adding a cancer vaccine (SurVaxM) to standard chemotherapy (temozolomide) helps people with advanced neuroendocrine tumors that are growing. The vaccine trains the immune system to attack cancer cells. About 60 adults with tumors that have spread will tak…

This early-stage trial tests whether specially designed immune cells (T-cells) can safely control viral infections like CMV, BK virus, or COVID-19 in cancer patients with weakened immune systems. The cells are modified to resist common anti-rejection drugs and target specific vir…

This study tests a two-step treatment for people with advanced cancer that blocks their main breathing passages. First, they get low-dose radiation to shrink the tumor. Then, they receive a light-sensitive drug and a laser treatment to destroy remaining tumor tissue. The goal is …

This study tests whether stem cells from a donor can help control heart failure in people whose hearts were weakened by a type of chemotherapy called anthracyclines. About 72 adults with low heart function will receive either standard care alone or standard care plus stem cells g…

This study looks at whether adding a procedure called vertebroplasty (which repairs broken spine bones) to radiation therapy can help patients whose cancer has spread to the spine. The goal is to reduce bone fractures and improve survival and quality of life. About 200 adults wit…

This early-phase study tests a wearable device that creates low-intensity electric fields (tumor treating fields) combined with either cabozantinib or a chemo-immunotherapy pair (nab-paclitaxel and atezolizumab) in people with advanced solid tumors in the abdomen or chest. The go…

This study tests whether giving triptorelin before chemotherapy can protect the ovaries of young women (under 40) with cancer. Chemotherapy drugs called alkylating agents can harm the ovaries, making it hard or impossible to get pregnant later. Triptorelin temporarily pauses ovar…

This study compares two drugs, neratinib and palbociclib, used together versus neratinib alone for people with HER2-positive gynecologic and other solid tumors (excluding breast cancer). The goal is to see if the combination can shrink or slow cancer growth. About 70 adults with …

This study tests whether infusions of stem cells from donated umbilical cord blood can help control severe pneumonia caused by COVID-19 in cancer patients. About 70 adults with moderate to critical illness will receive either stem cells plus standard care or standard care alone. …

This study is testing a new blood and urine test that looks for DNA markers to detect cancer early and identify where it started. Researchers at Mayo Clinic will enroll about 6,150 people, including those with and without cancer. The goal is to see if this simple test can accurat…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 who are CMV-positive will take letermovir after transplant. The goal is to see if the …

This study tests three ways to prevent nerve damage (numbness, tingling, pain) caused by taxane chemotherapy in people with solid tumors. About 777 participants will wear special wraps that cool and/or compress their arms and legs during treatment. The goal is to see which method…

This study tests a program called ASCENT that helps cancer survivors manage pain using an educational guide and coaching from community health workers and pain care managers. The goal is to improve pain and reduce the risk of opioid misuse. The study will include 660 adults with …

This study looks at whether a spinal cord stimulator can help people with long-term nerve pain caused by chemotherapy. About 20 adults who still have pain at least six months after finishing chemo will try this device. The goal is to see if it cuts pain by half or more and improv…

This study looks at whether creative arts like drawing, painting, and sculpting can help children with cancer feel better and improve their quality of life. Researchers will compare art activities to watching videos in 72 children aged 8 to 13 who were diagnosed with cancer in th…

This study tests whether Wisconsin ginseng can reduce severe fatigue in people with solid-tumor cancers. About 160 adults who are currently or previously treated for cancer and have significant fatigue will take either ginseng or a placebo. The goal is to see if ginseng improves …

This study looks at whether expressive writing can help cancer survivors cope with stress, especially during tough times like the COVID-19 pandemic. About 414 adults diagnosed with cancer in the last 3 years will participate online from home. They will write about their experienc…

This study tests a home-based exercise program for underserved cancer survivors and their caregivers. Participants will receive tailored workouts through the YMCA to help improve physical function and quality of life. The goal is to see if this approach is practical and acceptabl…

This study looks at whether giving the cancer drug nivolumab as a shot at home is as good as getting it at the clinic. About 50 adults with various cancers will try both ways to see which they prefer and how it affects their quality of life. The goal is to reduce the time, cost, …

This study looks at whether different types of massage can help lower anxiety in cancer patients while they receive chemotherapy. Many patients feel anxious during infusions, and massage has shown promise in reducing stress and other side effects. The trial will enroll 50 adults …

This study tests a telehealth program for caregivers of patients undergoing a major cancer surgery. The goal is to see if connecting caregivers with resources can reduce their stress, depression, and financial burden. About 50 adult caregivers will participate. The program is del…

This study tests whether acupressure—a gentle finger-pressure technique—can reduce anxiety in cancer patients receiving chemotherapy. Researchers will compare real acupressure to a sham (placebo) version in 78 adults with cancer. If effective, this drug-free method could offer a …

This study tests whether alteplase, a drug that dissolves blood clots, can improve drainage of fluid around the lungs and reduce shortness of breath in cancer patients. About 30 adults with malignant pleural effusion that is not draining well will receive either alteplase or a pl…

This study tests a virtual art therapy program for teens and young adults who have had cancer. The goal is to see if it can help with anxiety, depression, stress, and thinking skills. About 30 people aged 10 to 25 who were diagnosed in the past year or finished treatment within 5…

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether a short guided meditation before cancer surgery can reduce anxiety more than sitting in silence. About 300 adults scheduled for cancer surgery will be randomly assigned to either listen to a meditation recording or rest quietly. Researchers will measure a…

This study tests whether using virtual reality (VR) headsets is safe and helpful for cancer patients who feel anxious, depressed, or stressed during treatment. About 24 patients will use VR to explore calming scenes like forests or oceans. The goal is to see if this can improve t…

This study tests a short, virtual therapy called solution-focused brief therapy (SFBT-C) to see if it reduces anxiety and depression in teens and young adults who have had cancer. About 60 participants aged 15-39 who are distressed will either get SFBT-C or standard care. The goa…

This study tests a program called GEM-S, which combines a geriatric check-up with survivorship health education, to see if it helps older cancer survivors with daily activities, memory, and mental well-being. About 668 participants will be split into two groups: one gets GEM-S, t…

This study tests whether a virtual mindfulness-based stress reduction (MBSR) program can help cancer patients in underserved rural areas of Minnesota feel less stressed and anxious. About 30 adults with a history of cancer who report high emotional distress will take the online c…

This study tests whether a mobile app can teach family caregivers safe massage techniques to help cancer survivors with long-term nerve damage from chemotherapy. About 300 people (survivors and their caregivers) will use the app at home to see if it reduces pain, numbness, and ti…

This study tests whether a home-based exercise program designed for Hispanic and Latino/Latina teens and young adults who survived childhood cancer can help them be more active. Participants will use a Fitbit and get support through social media. The goal is to improve physical f…

This study tests whether a virtual diet program (low added sugar, high fiber, and omega-3s) can help cancer survivors manage nerve pain, numbness, and tingling caused by chemotherapy. About 50 adults who finished chemo at least three months ago and still have moderate nerve sympt…

This study tests two ways to help people on oral cancer drugs manage symptoms and emotional distress. One method uses automated phone calls to track symptoms and alert doctors. The other adds a self-help handbook and counseling for those feeling anxious or sad. The goal is to red…

This study tests whether L-theanine, a natural substance found in green tea, can help cancer survivors feel more relaxed and improve their mood. About 50 adults who have finished cancer treatment and are under surveillance will take L-theanine and report their stress and anxiety …

This study tests whether combining a nerve pain drug (duloxetine) with neurofeedback—a therapy that teaches you to change your own brain waves—can better relieve chemotherapy-induced nerve damage than either treatment alone. About 380 adults with nerve pain from past chemo will b…

This study tests a web-based toolkit called CONNECT designed to help rural older adults who have survived cancer manage emotional distress and anxiety. The toolkit provides interactive activities, educational materials, and personalized mental health resource recommendations. Res…

This study tests if a virtual group therapy program, combining Acceptance and Commitment Therapy (ACT) and compassion-based techniques, can improve psychological well-being in cancer patients. Researchers will enroll 200 adults at Mayo Clinic Arizona who have a cancer diagnosis o…

This study tests whether using a mask to deliver pressurized oxygen (non-invasive ventilation) can help cancer patients with respiratory failure breathe better and avoid needing a breathing tube. About 256 adults with cancer and low oxygen levels will be randomly assigned to rece…

This study tests a program called CostCOM that provides financial counseling and resources to cancer patients. The goal is to see if it helps patients stick to their treatments and reduces financial hardship. About 760 patients will take part, and researchers will track whether t…

This study is testing a program called TEAM Me that uses tokens and rewards to encourage exercise in children and young adults with cancer who are recovering from a stem cell transplant. The goal is to see if the program is doable and safe, and if it helps improve physical fitnes…

This study is testing whether using virtual reality (VR) can help patients feel better during their bone marrow transplant hospital stay. Researchers will compare VR sessions focused on relaxation and nature to standard care alone. They want to see if VR reduces symptoms like pai…

This study aims to see if blood samples from cancer patients can be used to create personalized stem cell models that predict side effects from treatments like chemotherapy. Researchers will compare cells from patients who had side effects with those who did not. The goal is to b…

This study places cancer patients in special hospital rooms equipped with cameras, microphones, and temperature sensors. The goal is to see if these tools can help nurses and doctors detect early signs of confusion, falls, sleep trouble, or mood changes. About 134 patients and th…

This study aims to learn more about cancer genes in people from different ethnic backgrounds. Researchers will test 1,800 adults with various solid tumors to see how common certain gene changes are. The goal is to improve cancer risk assessment and tailor screening for these popu…

This study looks at how the COVID-19 pandemic changed the emotional, financial, physical, and social well-being of teens and young adults who have or had cancer. Researchers will survey 600 participants to understand their stress and health behaviors during the pandemic. The goal…

This study is a large registry for children and young adults with cancer. It collects health information and leftover tumor or blood samples over time. The goal is to help doctors find better ways to treat and care for these patients. Up to 75,000 people will take part.

This study analyzes tumor samples from 12,000 cancer patients to find gene changes (mutations). The goal is to match each person with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to improve future treatme…

This study brings together a panel of prostate cancer experts to agree on the most important pieces of information that should be included in medical reports. The goal is to create a standard way of reporting key data in electronic health records, which could help doctors better …

This study follows 250 young adults (ages 18-39) recently diagnosed with cancer to see how their social relationships and physical activity change over time and affect their quality of life. Researchers will track hospitalizations, treatment details, exercise habits, and well-bei…

This study surveys 10 cancer patients at USC Norris Cancer Center to learn what they know and think about integrative oncology services such as acupuncture, massage, and nutrition counseling. The goal is to understand patient interest and identify barriers to offering these servi…

This study tracks side effects and treatment results in 170 advanced cancer patients receiving anti-VEGF therapy. Researchers want to see if certain side effects are linked to how well the cancer responds. The goal is to help doctors better predict outcomes and manage treatment.

This study looks at the genetic changes in cancer cells from Indigenous American people in the Southwest. The goal is to learn more about these cancers to improve screening and treatment. Researchers will enroll 300 adults who have or had cancer and identify as Indigenous America…

This study looks at why some people get mild or serious side effects from immunotherapy drugs used to treat cancer. Researchers will track over 2,000 patients to see how age, gender, and other health conditions affect side effects. The goal is to help doctors choose safer treatme…

This study collects blood and tissue samples from 2000 people—some with cancer, some without—to help researchers develop and improve blood tests that can detect many types of cancer early. Participants provide samples that are stored and later used to test new diagnostic methods.…

This study looks at how physical activity relates to memory and thinking in people who survived cancer as teens or young adults. Researchers will use computer-based brain games to measure cognitive performance. The goal is to understand these connections, not to test a new treatm…

This study uses virtual reality to show people two versions of the same neighborhood—one messy and one clean—to measure how it affects their heart rate, sweat, and feelings. Researchers want to understand if the look of a neighborhood can impact health. About 32 adults with cance…

This study looks at whether recording personal messages of wisdom and hope can help maintain dignity for people with serious illnesses like cancer and their caregivers. About 40 adults with a chronic or progressive illness will make recordings and complete surveys before and afte…

This study is developing and testing a culturally informed patient navigation program for American Indian and Alaska Native cancer patients in rural California. The goal is to reduce delays between diagnosis and treatment by providing personalized support and addressing barriers …

This study looks at how patients and doctors discuss immunotherapy, a type of cancer treatment. Researchers want to find out where patients get their information, what they understand, and how doctors explain it. They will also test if educational videos help patients learn more …

This study looks at how doctors' words and actions affect distress in cancer patients receiving radiation therapy. Researchers will ask 5,000 adults about their experiences to find out which behaviors help or hurt. The goal is to improve how doctors communicate and support patien…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study looks at how the bacteria in your gut might cause stomach issues like diarrhea and colitis when you take certain cancer drugs called immune checkpoint inhibitors. Researchers will collect stool, blood, and tissue samples from 800 people with melanoma, lung, or genitour…

This study enrolls 50 adults with any type of cancer to see if watching videos and reading materials improves their understanding of cancer clinical trials. Participants complete a survey before and after the educational materials to measure changes in knowledge and beliefs. The …

This study is testing whether step counts from wearable activity trackers can help predict when cancer patients undergoing radiation therapy might need to go to the emergency room or be hospitalized. Researchers will collect step data from 260 adults with cancer before, during, a…

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study collects tissue and blood samples from 1,500 people with prostate or bladder cancer that has returned or spread. Researchers will analyze these samples to find new biomarkers and understand why some cancers stop responding to treatment. The goal is to improve future th…

This study aims to find normal levels for a new blood and urine test that might one day help screen for cancer. Researchers at Mayo Clinic will collect samples from 10,000 people without cancer to establish a baseline. The goal is to improve early detection, not to treat or cure …

This study tests whether a computer-generated character (called PERLA) can help cancer patients learn about genetic testing as well as a human counselor does. The goal is to make genetic testing easier to access for people who often miss out, like those in rural areas or who spea…

This study aims to understand how the body's immune cells react to a new type of vaccine (neoantigen vaccine) that helps the immune system recognize and fight cancer. Researchers will collect blood samples from 24 people with solid tumors or healthy volunteers to study immune cel…

This study looks at a new way to help family members of cancer patients learn about their own inherited cancer risk. Instead of relying on the patient to share genetic test results, doctors will directly contact at-risk relatives to offer genetic counseling and testing. The goal …

This study aims to understand why some cancer patients develop heart issues after chemotherapy while others do not. Researchers will collect blood samples from 1,000 adults who have had chemotherapy for any type of cancer. The goal is to find biological markers that could predict…

This study gathers information on short- and long-term side effects from proton therapy in adults with various cancers. Researchers will collect data from up to 5,000 participants to better understand and predict these side effects. The goal is to improve future treatment plannin…

This study collects and analyzes genetic material (DNA, RNA) and tissue samples from 500 adults with cancer to identify markers and causes of the disease. Researchers aim to build a biobank to improve cancer prevention, early detection, and treatment. Participants must have a con…

This study tests an online platform for people with lung, colorectal, breast, or prostate cancer to track medication side effects and concerns at home. About 80 participants will use the tool and report on its ease of use and how it affects their health. The goal is to see if sel…

This study surveys 250 U.S. pulmonologists to learn how the COVID-19 pandemic changed their lung procedures, staffing, and clinic operations. The goal is to help lung programs improve and guide future research for better pandemic preparedness. Participants are doctors who are mem…

This study tests whether special breathing exercises can improve brain and mental health in people with multiple sclerosis or cancer, and their caregivers. Researchers will use MRI scans to see how breathing affects oxygen flow in the brain. The goal is to understand the connecti…

This study aims to improve how we measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers will ask 3,000 participants—including patients, survivors, and their caregivers—about topics like body image, fertility concerns, and financial stress. …

This study tests whether a virtual community health educator (vCHE) can help more cancer patients and their caregivers learn about and sign up for clinical trials. The vCHE is a computer character that speaks English or Spanish and offers personalized guidance. The goal is to inc…

This study looks at how sex and gender might change the side effects people experience during immunotherapy for cancer. Researchers will track symptoms and quality of life in 100 adults starting standard immunotherapy. The goal is to better understand these differences to improve…

This study looks at whether a supervised exercise and nutrition program in the community is practical and helpful for cancer survivors. Researchers want to see if it improves survivors' confidence, physical fitness, and quality of life. The study will include 150 adults who have …

This study looks at how the natural bacteria in your gut (the microbiome) can change the way cancer treatments work. Researchers will collect samples from 3,000 cancer patients to find links between gut bacteria and treatment success. No new drugs are tested—the goal is to learn …

This study looks at whether a special health check-up for older adults with cancer, done over video, can find their weak spots and guide their care. It involves 216 people aged 65 and older starting new cancer treatment. The goal is to see if this approach helps patients complete…

This study collects tissue and blood samples from 5,000 cancer patients to create lab models, like patient-derived xenografts and cell lines. The goal is to help scientists better understand cancer and test new treatments. Participants must be over 2 months old and have a confirm…

This study is testing a mobile app called PACT that helps people with advanced cancer talk about and plan the medical care they would want if they couldn't speak for themselves. The app involves both patients and their loved ones. The goal is to see if the app is easy to use and …

This study tests a tool kit called SALSA that tracks stress, mood, and speech to catch thinking problems early in people getting CAR-T therapy for cancer. About 38 adults will use the tool during their hospital stay. The goal is to see if it's practical and better than the usual …

This study looks at whether a 6-week group program can help young adults (ages 18-39) who have finished cancer treatment feel more prepared for daily life. Participants will attend weekly group meetings led by social workers and complete surveys about their quality of life and me…

This study is testing new blood tests that look for signs of many different cancers at the same time. Researchers want to see if these tests can find cancer early, when treatment works best. About 24,000 adults aged 45 to 75 who do not have cancer will be split into three groups:…