Ice wraps may shield nerves from chemo pain
NCT ID NCT05642611
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether cooling and compressing the arms and legs during taxane chemotherapy can prevent peripheral neuropathy—a common side effect causing numbness, tingling, or pain. About 777 cancer patients will be randomly assigned to one of three approaches: cryocompression (cooling + compression), continuous compression, or low cyclic compression. The goal is to see which method best prevents nerve damage.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- cryocompression therapy (cooling and compression of limbs)
- What this could lead to
- If it works, this could give cancer patients a simple, non-drug way to prevent painful nerve damage from taxane chemotherapy.
- What could go wrong
- This is a large phase III trial, but it's still possible that none of the compression methods work better than the others, or that the devices are too uncomfortable for patients to use consistently.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Baptist Health Lexington
RECRUITINGLexington, Kentucky, 40503, United States
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Bon Secours Saint Francis Medical Center
RECRUITINGMidlothian, Virginia, 23114, United States
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CaroMont Regional Medical Center
RECRUITINGGastonia, North Carolina, 28054, United States
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Cone Health Cancer Center
RECRUITINGGreensboro, North Carolina, 27403, United States
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Contra Costa Regional Medical Center
SUSPENDEDMartinez, California, 94553-3156, United States
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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
RECRUITINGGrand Rapids, Michigan, 49503, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITINGLebanon, New Hampshire, 03756, United States
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Emory University Hospital/Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
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Fred Hutchinson Cancer Center
SUSPENDEDSeattle, Washington, 98109, United States
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Gibbs Cancer Center-Gaffney
RECRUITINGGaffney, South Carolina, 29341, United States
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Gibbs Cancer Center-Pelham
RECRUITINGGreer, South Carolina, 29651, United States
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Good Samaritan Hospital - Cincinnati
RECRUITINGCincinnati, Ohio, 45220, United States
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Henry Ford Macomb Hospital-Clinton Township
RECRUITINGClinton Township, Michigan, 48038, United States
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Kapiolani Medical Center for Women and Children
RECRUITINGHonolulu, Hawaii, 96826, United States
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Margaret R Pardee Memorial Hospital
RECRUITINGHendersonville, North Carolina, 28791, United States
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McLeod Regional Medical Center
RECRUITINGFlorence, South Carolina, 29506, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITINGNew York, New York, 10032, United States
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Regional Cancer Center at Johnson City Medical Center
RECRUITINGJohnson City, Tennessee, 37604, United States
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Rhode Island Hospital
RECRUITINGProvidence, Rhode Island, 02903, United States
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SMC Center for Hematology Oncology Union
RECRUITINGUnion, South Carolina, 29379, United States
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STCC at DHR Health Institute for Research and Development
RECRUITINGEdinburg, Texas, 78539, United States
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Smilow Cancer Hospital Care Center-Fairfield
RECRUITINGFairfield, Connecticut, 06824, United States
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Smilow Cancer Hospital Care Center-Trumbull
RECRUITINGTrumbull, Connecticut, 06611, United States
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Spartanburg Medical Center
RECRUITINGSpartanburg, South Carolina, 29303, United States
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State University of New York Upstate Medical University
ACTIVE_NOT_RECRUITINGSyracuse, New York, 13210, United States
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The Valley Hospital - Luckow Pavilion
RECRUITINGParamus, New Jersey, 07652, United States
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University of Alabama at Birmingham Cancer Center
RECRUITINGBirmingham, Alabama, 35233, United States
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University of Kansas Cancer Center
RECRUITINGKansas City, Kansas, 66160, United States
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University of Kansas Hospital-Indian Creek Campus
RECRUITINGOverland Park, Kansas, 66211, United States
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University of Kansas Hospital-Westwood Cancer Center
RECRUITINGWestwood, Kansas, 66205, United States
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University of New Mexico Cancer Center
RECRUITINGAlbuquerque, New Mexico, 87106, United States
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University of Washington Medical Center - Montlake
RECRUITINGSeattle, Washington, 98195, United States
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Valley Health System Ridgewood Campus
RECRUITINGRidgewood, New Jersey, 07450, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
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