New hope: drug may shield kids from virus after transplant

NCT ID NCT05711667

Recruiting now Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug lowers the chance of serious CMV infection compared to expected rates without it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Letermovir (an antiviral drug)
What this could lead to: If it works, this could provide a safe way to prevent CMV infection in children after stem cell transplant, reducing hospital stays and severe illness.
What could go wrong: This is a single-arm trial with no placebo group, so results may be less definitive. The drug may still fail to prevent CMV or cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cancer hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm cytomegalovirus infection prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOPOIETIC AND LYMPHOID CELL NEOPLASM MALIGNANT SOLID NEOPLASM

Contacts and locations

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Locations

Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital New Orleans
RECRUITING

New Orleans, Louisiana, 70118, United States
Children's Hospital of Alabama
RECRUITING

Birmingham, Alabama, 35233, United States

Contact Email: •••••@•••••
Children's Hospital of Michigan
RECRUITING

Detroit, Michigan, 48201, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96826, United States
Medical City Dallas Hospital
RECRUITING

Dallas, Texas, 75230, United States
Methodist Children's Hospital of South Texas
RECRUITING

San Antonio, Texas, 78229, United States
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Email: •••••@•••••
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Saint Jude Children's Research Hospital
ACTIVE_NOT_RECRUITING

Memphis, Tennessee, 38105, United States
The Children's Hospital at TriStar Centennial
RECRUITING

Nashville, Tennessee, 37203, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
VCU Massey Comprehensive Cancer Center
NOT_YET_RECRUITING

Richmond, Virginia, 23298, United States
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••

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