Children's Oncology Group

This study aims to see if adding a nutrient supplement called levocarnitine to standard chemotherapy can protect the liver in adolescents and young adults (ages 15-39) being treated for leukemia or lymphoma. A key chemotherapy drug, asparaginase, often causes severe liver damage …

This early-stage study is testing a new oral drug, AZD1390, given alongside standard radiation therapy in children and young adults with aggressive brain tumors. The main goals are to find the safest dose of the drug and to see what side effects occur when it's combined with radi…

This study aims to find out which of two surgical methods is better for removing lung tumors that have spread from bone cancer (osteosarcoma) in patients under 50. It directly compares traditional open-chest surgery with a less invasive 'keyhole' camera-guided surgery. The main g…

This early-stage study is testing a new drug, imetelstat, combined with two standard chemotherapy drugs (fludarabine and cytarabine) in children and young adults. It aims to find the safest dose and see if this combination can help control three types of aggressive blood cancers …

This study is testing a new two-drug combination for children, teens, and young adults whose solid tumors or a rare liver cancer called fibrolamellar carcinoma have come back or stopped responding to standard treatments. The main goals are to find the safest and most effective do…

This study is testing if adding a drug called melphalan, injected directly into the eye, to standard chemotherapy is safe and more effective for treating a serious childhood eye cancer called retinoblastoma. It focuses on children under 18 with a specific, high-risk form of the d…

This study aims to reduce a major side effect of childhood brain cancer treatment: hearing loss. It tests whether adding a drug called sodium thiosulfate to standard chemotherapy can protect hearing in children with average-risk medulloblastoma. For children with low-risk feature…

This study is testing new drug combinations for children and young adults newly diagnosed with a serious blood cancer called acute myeloid leukemia (AML). It aims to see if a newer, packaged chemotherapy (CPX-351) works better and is safer for the heart than standard chemotherapy…

This early-stage trial is testing a new drug called CBL0137 in children and young adults (ages 1-21) whose solid tumors, brain tumors, or lymphoma have come back or stopped responding to standard treatments. The main goals are to find the safest dose and see if the drug can help …

This study is testing whether a drug called triptorelin can protect the ovaries in young women and adolescents receiving chemotherapy for cancer. Chemotherapy can damage the ovaries, which may make it difficult or impossible to have children later. Researchers want to see if givi…

This study is testing a personalized treatment plan for children and young adults with a rare, localized brain tumor called a non-germinomatous germ cell tumor (NGGCT). Doctors first give chemotherapy and then decide the next steps based on how well the tumor responds. The goal i…

This study is testing a new drug called tegavivint in children, teens, and young adults whose solid tumors or lymphomas have come back or haven't responded to other treatments. The main goals are to find the safest dose, understand the side effects, and see if the drug can help s…

This study is testing different combinations of surgery and chemotherapy for children with pleuropulmonary blastoma (PPB), a rare and aggressive lung tumor. For early-stage tumors, it compares surgery alone to surgery followed by chemotherapy. For more advanced tumors, it tests w…

This large study is testing if adding a targeted drug called inotuzumab ozogamicin to standard chemotherapy and immunotherapy improves long-term survival for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). It will also track outcomes for pati…

This study is testing a new approach for children and young adults with a type of brain tumor called a central nervous system germinoma. The goal is to see if using a lower dose of radiation therapy after initial chemotherapy can still effectively control the tumor while reducing…

This study aims to improve treatment for children with Wilms tumor, the most common kidney cancer in kids. It will test whether doctors can use specific features of a child's tumor to choose the right amount and type of chemotherapy. The goal is to cure more children while reduci…

This large, late-stage study is testing if adding one of two new treatments to the current intensive therapy helps children with newly diagnosed, high-risk neuroblastoma. One approach uses a radioactive drug that targets the tumor. The other uses a daily pill (lorlatinib) for chi…

This large study has two main goals. First, it tests if close monitoring after surgery is a safe approach for children and adults with low-risk germ cell tumors, avoiding chemotherapy unless the cancer returns. Second, for patients with higher-risk tumors that need treatment, it …

This study is testing two different combinations of chemotherapy drugs for children and young adults with aggressive forms of Wilms tumor, a childhood kidney cancer. It is for patients whose cancer is newly diagnosed and considered high-risk (diffuse anaplastic) or whose cancer h…

This study is for children and young adults newly diagnosed with a specific type of soft tissue cancer called low-risk rhabdomyosarcoma. The main goal is to see if doctors can maintain the same high survival rates while using less intense chemotherapy, which could reduce side eff…

This study is testing a drug called inotuzumab ozogamicin for children and young adults whose B-cell leukemia has come back or hasn't responded to other treatments. The drug is designed to find and kill only the cancer cells. Researchers want to see how well it works and how safe…

This study is testing whether a drug called letermovir can prevent a serious viral infection called cytomegalovirus (CMV) in children and teenagers who have received a stem cell transplant. After a transplant, patients' immune systems are very weak, making them highly vulnerable …

This study is testing a home-based fitness program designed specifically for Hispanic and Latino young adults who survived childhood cancer. The program uses a Fitbit, a mobile app, and a private social media group to encourage physical activity. Researchers want to see if this c…

This study aims to understand why one twin develops a childhood brain tumor while their identical twin does not. Researchers will collect blood and saliva samples from 25 pairs of identical twins in this situation. They will look for tiny genetic differences that might explain wh…

This study aims to understand the long-term health effects of childhood leukemia treatment in people with Down syndrome. Researchers will compare 330 survivors with Down syndrome who had leukemia to similar individuals without cancer history. By identifying health risks and quali…

This study is creating a large registry and tissue bank for children and young adults with cancer. It collects health information and leftover tissue samples from patients up to age 25 to help researchers understand these diseases better. The goal is to use this information to im…

This study aims to understand why some young Hodgkin lymphoma survivors develop heart problems years after their cancer treatment. Researchers will check blood samples for specific markers and perform heart scans on 190 survivors who received certain chemotherapy drugs. The goal …

This study follows over 1,100 children and young adults who survived germ cell tumors to understand the long-term effects of their cancer treatments. Researchers will collect health information and analyze tumor samples to identify genetic patterns that could predict which patien…