Children's Oncology Group

This study tests whether tailoring treatment based on each child's risk of relapse can improve cure rates for Wilms tumor, a common childhood kidney cancer. About 1,656 children with favorable histology Wilms tumor will receive therapy adjusted according to tumor features and ear…

This study is for children and young adults (ages 3 to 29) with a rare brain tumor called non-germinomatous germ cell tumor that hasn't spread. Doctors will first give chemotherapy and see how well the tumor responds. If it shrinks a lot, patients get a lower dose of radiation to…

This study is for children and young adults with a new diagnosis of low-risk rhabdomyosarcoma, a type of soft tissue cancer. The goal is to see if a shorter course of two chemotherapy drugs (vincristine and dactinomycin) can keep very low-risk patients healthy while reducing side…

This study tests if adding a chemotherapy drug called melphalan directly into the eye can help treat a childhood eye cancer called retinoblastoma, especially when cancer cells are floating in the eye's jelly-like fluid (vitreous seeds). About 26 children with newly diagnosed reti…

This study is for children with a type of brain cancer called medulloblastoma. It tests if a drug called sodium thiosulfate can prevent hearing loss caused by the chemotherapy drug cisplatin. For children with a lower risk of the cancer returning, the study also tests if a less i…

This study looks at the best way to treat a rare childhood lung tumor called pleuropulmonary blastoma (PPB). For early-stage (type I) tumors, it compares surgery alone to surgery followed by chemotherapy to see if chemo is needed. For more advanced (types II and III) tumors, it t…

This study tests whether adding a radioactive drug (131I-MIBG) or a targeted pill (lorlatinib) to standard intensive therapy helps children with high-risk neuroblastoma live longer without the cancer coming back. About 750 children and young adults (ages 1 to 30) with newly diagn…

This study tests whether two newer drugs, CPX-351 and gilteritinib, work better than standard chemotherapy for children and young adults with newly diagnosed acute myeloid leukemia (AML). About 1,186 participants under age 22 will be enrolled. The goal is to improve survival and …

This early-stage study is testing a new drug called AZD1390 combined with radiation therapy in children and young adults with aggressive brain tumors (high-grade glioma, diffuse midline glioma, or DIPG). The goal is to find the safest dose and see if the combination helps control…

This study tests a drug called inotuzumab ozogamicin in children and young adults (ages 1 to 21) whose B-cell acute lymphoblastic leukemia (B-ALL) has come back or stopped responding to treatment. The drug works like a smart bomb, attaching to a marker on leukemia cells and deliv…

This study compares two surgical methods—open surgery (one large cut) and keyhole surgery (several small cuts with a camera)—to remove osteosarcoma tumors that have spread to the lungs. About 62 patients under 50 with up to 4 lung nodules will be randomly assigned to one of the t…

This study tests an experimental drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors by …

This study tests a new drug combination (DT2216 plus irinotecan) in children, teens, and young adults whose solid tumors have returned or not responded to treatment. The goal is to find the safest dose and see if the combo can shrink tumors, especially in a rare liver cancer call…

This study looks at two approaches for people with germ cell tumors. For low-risk patients, doctors will monitor closely after surgery to see if the tumor comes back. For standard-risk patients whose cancer has spread, the study compares two chemotherapy drugs (carboplatin vs cis…

This early-stage trial tests a new drug called imetelstat combined with two standard chemotherapies (fludarabine and cytarabine) in children and teens with acute myeloid leukemia, myelodysplastic syndrome, or juvenile myelomonocytic leukemia that has returned or not responded to …

This study tests a drug called tegavivint in children, teens, and young adults (ages 1 to 30) whose solid tumors have returned or are not responding to standard treatments. The drug works by blocking a key signal that tells cancer cells to grow. The trial aims to find the safest …

This study tests whether giving triptorelin before chemotherapy can protect the ovaries of young women (under 40) with cancer. Chemotherapy drugs called alkylating agents can harm the ovaries, making it hard or impossible to get pregnant later. Triptorelin temporarily pauses ovar…

This study is for children and young adults (ages 3 to 29) with a type of brain tumor called germinoma. Researchers want to see if giving a lower dose of radiation after chemotherapy can still control the tumor while causing fewer long-term side effects. About 240 participants wi…

This study tests whether adding a targeted drug called inotuzumab ozogamicin to standard chemotherapy and immunotherapy can improve outcomes for children and young adults with high-risk B-cell acute lymphoblastic leukemia (B-ALL). About 5,951 participants will receive either the …

This study tests two powerful chemotherapy combinations in children with a rare, aggressive kidney cancer called Wilms tumor. One group has newly diagnosed disease, the other has cancer that returned after initial treatment. The goal is to see if these drug mixes can stop the can…

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 who are CMV-positive will take letermovir after transplant. The goal is to see if the …

This study tests whether a home-based exercise program designed for Hispanic and Latino/Latina teens and young adults who survived childhood cancer can help them be more active. Participants will use a Fitbit and get support through social media. The goal is to improve physical f…

This study follows over 1,100 children and teens diagnosed with germ cell tumors to learn about short- and long-term side effects from treatment, like hearing loss. Researchers will also analyze tumor DNA and other markers to better predict which patients might have their cancer …

This study looks at 50 twins where only one child has a central nervous system tumor. Researchers will compare DNA from blood and saliva samples to see if small genetic differences (called somatic mosaicism) explain why one twin gets cancer and the other stays healthy. The goal i…

This study is a large registry for children and young adults with cancer. It collects health information and leftover tumor or blood samples over time. The goal is to help doctors find better ways to treat and care for these patients. Up to 75,000 people will take part.

This study looks at how certain blood cell changes (called clonal hematopoiesis) after Hodgkin lymphoma treatment might be linked to heart problems later in life. Researchers will check blood samples from 190 survivors who had chemotherapy as children or teens. The goal is to fin…

This study is for people with Down syndrome who have had acute leukemia and are now at least 6 years old. Researchers want to learn about long-term health problems that may appear after cancer treatment. By understanding these risks, doctors hope to create better follow-up care g…

This study examines stored umbilical cord blood from 300 children who later developed leukemia. Researchers will look for the same genetic mutations found in the children's leukemia cells within their newborn cord blood. The goal is to understand how and when these cancer-causing…