Could less radiation be enough? new trial hopes to reduce side effects for kids with brain tumors

NCT ID NCT06368817

Recruiting now Disease control Sponsor: Children's Oncology Group Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 3 times

Summary

This phase II trial is testing whether giving a lower dose of radiation after chemotherapy can effectively treat children and young adults with central nervous system germinomas, a type of brain tumor. The study will enroll 240 participants aged 3 to 29. After initial chemotherapy with carboplatin and etoposide, patients receive either proton or 3D conformal radiation at a reduced dose based on how well the tumor responded. The goal is to maintain high cure rates while minimizing long-term side effects from radiation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Carboplatin and Etoposide chemotherapy followed by reduced-dose proton or 3D conformal radiation therapy
What this could lead to: If successful, this could mean children with CNS germinomas can receive lower radiation doses, reducing long-term side effects while still controlling the disease.
What could go wrong: This is a phase II trial, so it is still testing whether the lower radiation dose is as effective as the standard dose. There is a risk that the reduced radiation may not control the tumor as well, leading to recurrence.

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Conditions

The condition(s) this trial relates to.

brain germinoma central nervous system germinoma diabetes insipidus germinoma pineal region germinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BASAL GANGLIA GERMINOMA CENTRAL NERVOUS SYSTEM GERMINOMA DIABETES INSIPIDUS GERMINOMA PINEAL REGION GERMINOMA SUPRASELLAR GERMINOMA THALAMIC GERMINOMA

Contacts and locations

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Locations

Albany Medical Center
RECRUITING

Albany, New York, 12208, United States
Alfred I duPont Hospital for Children
RECRUITING

Wilmington, Delaware, 19803, United States
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
RECRUITING

Las Vegas, Nevada, 89135, United States

Contact Email: •••••@•••••
Arkansas Children's Hospital
RECRUITING

Little Rock, Arkansas, 72202-3591, United States
Arnold Palmer Hospital for Children
RECRUITING

Orlando, Florida, 32806, United States
BI-LO Charities Children's Cancer Center
RECRUITING

Greenville, South Carolina, 29605, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77030, United States
British Columbia Children's Hospital
RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
C S Mott Children's Hospital
RECRUITING

Ann Arbor, Michigan, 48109, United States
CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL)
RECRUITING

Québec, G1V 4G2, Canada
CancerCare Manitoba
RECRUITING

Winnipeg, Manitoba, R3E 0V9, Canada
Cardinal Glennon Children's Medical Center
RECRUITING

St Louis, Missouri, 63104, United States
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITING

Atlanta, Georgia, 30329, United States
Children's Hospital
RECRUITING

London, Ontario, N6A 5W9, Canada
Children's Hospital Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital and Medical Center of Omaha
RECRUITING

Omaha, Nebraska, 68114, United States
Children's Hospital of Orange County
RECRUITING

Orange, California, 92868, United States

Contact Email: •••••@•••••
Children's Hospital of Philadelphia
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Children's Hospital of Pittsburgh of UPMC
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospital of San Antonio
RECRUITING

San Antonio, Texas, 78207, United States
Children's Hospital of The King's Daughters
RECRUITING

Norfolk, Virginia, 23507, United States

Contact Email: •••••@•••••
Children's Hospitals and Clinics of Minnesota - Minneapolis
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospitals and Clinics
RECRUITING

Kansas City, Missouri, 64108, United States

Contact Email: •••••@•••••
Children's National Medical Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Connecticut Children's Medical Center
RECRUITING

Hartford, Connecticut, 06106, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
RECRUITING

Grand Rapids, Michigan, 49503, United States
Dana-Farber Cancer Institute
RECRUITING

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
RECRUITING

Lebanon, New Hampshire, 03756, United States
Dell Children's Medical Center of Central Texas
RECRUITING

Austin, Texas, 78723, United States
Driscoll Children's Hospital
RECRUITING

Corpus Christi, Texas, 78411, United States
Hackensack University Medical Center
RECRUITING

Hackensack, New Jersey, 07601, United States
Hospital for Sick Children
RECRUITING

Toronto, Ontario, M5G 1X8, Canada
IWK Health Centre
RECRUITING

Halifax, Nova Scotia, B3K 6R8, Canada

Contact Email: •••••@•••••
John Hunter Children's Hospital
SUSPENDED

Hunter Regional Mail Centre, New South Wales, 2310, Australia
Johns Hopkins All Children's Hospital
RECRUITING

St. Petersburg, Florida, 33701, United States
Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITING

Baltimore, Maryland, 21287, United States
Kapiolani Medical Center for Women and Children
RECRUITING

Honolulu, Hawaii, 96826, United States
Laura and Isaac Perlmutter Cancer Center at NYU Langone
RECRUITING

New York, New York, 10016, United States

Contact Email: •••••@•••••
Loma Linda University Medical Center
RECRUITING

Loma Linda, California, 92354, United States
Loyola University Medical Center
RECRUITING

Maywood, Illinois, 60153, United States
Lucile Packard Children's Hospital Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Lurie Children's Hospital-Chicago
RECRUITING

Chicago, Illinois, 60611, United States
Maine Children's Cancer Program
RECRUITING

Scarborough, Maine, 04074, United States

Contact Email: •••••@•••••
Massachusetts General Hospital Cancer Center
RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic in Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
McMaster Children's Hospital at Hamilton Health Sciences
RECRUITING

Hamilton, Ontario, L8N 3Z5, Canada
Medical City Dallas Hospital
RECRUITING

Dallas, Texas, 75230, United States
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
Mount Sinai Hospital
RECRUITING

New York, New York, 10029, United States
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITING

New York, New York, 10032, United States

Contact Email: •••••@•••••
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nemours Children's Clinic - Pensacola
RECRUITING

Pensacola, Florida, 32504, United States

Contact Email: •••••@•••••
Nemours Children's Clinic-Jacksonville
RECRUITING

Jacksonville, Florida, 32207, United States
Nemours Children's Hospital
RECRUITING

Orlando, Florida, 32827, United States
Newark Beth Israel Medical Center
RECRUITING

Newark, New Jersey, 07112, United States
Nicklaus Children's Hospital
RECRUITING

Miami, Florida, 33155, United States
Norton Children's Hospital
RECRUITING

Louisville, Kentucky, 40202, United States

Contact Email: •••••@•••••
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States

Contact Email: •••••@•••••
Perth Children's Hospital
RECRUITING

Perth, Western Australia, 6009, Australia

Contact Email: •••••@•••••
Phoenix Childrens Hospital
RECRUITING

Phoenix, Arizona, 85016, United States
Primary Children's Hospital
RECRUITING

Salt Lake City, Utah, 84113, United States
Prisma Health Richland Hospital
RECRUITING

Columbia, South Carolina, 29203, United States
Providence Sacred Heart Medical Center and Children's Hospital
RECRUITING

Spokane, Washington, 99204, United States
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Rady Children's Hospital - San Diego
RECRUITING

San Diego, California, 92123, United States
Rainbow Babies and Childrens Hospital
RECRUITING

Cleveland, Ohio, 44106, United States
Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Riley Hospital for Children
RECRUITING

Indianapolis, Indiana, 46202, United States
Royal Children's Hospital
RECRUITING

Parkville, Victoria, 3052, Australia
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
RECRUITING

New Brunswick, New Jersey, 08903, United States
Sacred Heart Hospital
ACTIVE_NOT_RECRUITING

Pensacola, Florida, 32504, United States
Saint Christopher's Hospital for Children
RECRUITING

Philadelphia, Pennsylvania, 19134, United States
Saint Joseph's Hospital/Children's Hospital-Tampa
RECRUITING

Tampa, Florida, 33607, United States
Saint Joseph's Regional Medical Center
RECRUITING

Paterson, New Jersey, 07503, United States
Saint Jude Children's Research Hospital
RECRUITING

Memphis, Tennessee, 38105, United States

Contact Email: •••••@•••••
Saint Luke's Cancer Institute - Boise
RECRUITING

Boise, Idaho, 83712, United States
Saint Peter's University Hospital
RECRUITING

New Brunswick, New Jersey, 08901, United States
Sanford Broadway Medical Center
RECRUITING

Fargo, North Dakota, 58122, United States

Contact Email: •••••@•••••
Sanford USD Medical Center - Sioux Falls
RECRUITING

Sioux Falls, South Dakota, 57117-5134, United States

Contact Email: •••••@•••••
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
State University of New York Upstate Medical University
RECRUITING

Syracuse, New York, 13210, United States
Summerlin Hospital Medical Center
RECRUITING

Las Vegas, Nevada, 89144, United States

Contact Email: •••••@•••••
Sydney Children's Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
The Children's Hospital at Westmead
RECRUITING

Westmead, New South Wales, 2145, Australia
The Montreal Children's Hospital of the MUHC
RECRUITING

Montreal, Quebec, H3H 1P3, Canada

Contact Email: •••••@•••••
The Steven and Alexandra Cohen Children's Medical Center of New York
RECRUITING

New Hyde Park, New York, 11040, United States
UCSF Benioff Children's Hospital Oakland
RECRUITING

Oakland, California, 94609, United States
UCSF Medical Center-Mission Bay
RECRUITING

San Francisco, California, 94158, United States

Contact Email: •••••@•••••
UNC Lineberger Comprehensive Cancer Center
RECRUITING

Chapel Hill, North Carolina, 27599, United States

Contact Email: •••••@•••••
USA Health Strada Patient Care Center
RECRUITING

Mobile, Alabama, 36604, United States
UT MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
UT Southwestern/Simmons Cancer Center-Dallas
RECRUITING

Dallas, Texas, 75390, United States

Contact Email: •••••@•••••
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada

Contact Email: •••••@•••••
University of Chicago Comprehensive Cancer Center
RECRUITING

Chicago, Illinois, 60637, United States

Contact Email: •••••@•••••
University of Illinois
RECRUITING

Chicago, Illinois, 60612, United States
University of Iowa/Holden Comprehensive Cancer Center
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami Miller School of Medicine-Sylvester Cancer Center
RECRUITING

Miami, Florida, 33136, United States
University of Minnesota/Masonic Cancer Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Mississippi Medical Center
RECRUITING

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Oklahoma Health Sciences Center
RECRUITING

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center at San Antonio
RECRUITING

San Antonio, Texas, 78229, United States

Contact Email: •••••@•••••
University of Virginia Cancer Center
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Email: •••••@•••••
University of Wisconsin Carbone Cancer Center - University Hospital
RECRUITING

Madison, Wisconsin, 53792, United States

Contact Email: •••••@•••••
Vanderbilt University/Ingram Cancer Center
RECRUITING

Nashville, Tennessee, 37232, United States
Wake Forest University Health Sciences
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States

Contact Email: •••••@•••••
Women's and Children's Hospital-Adelaide
RECRUITING

North Adelaide, South Australia, 5006, Australia
Yale University
RECRUITING

New Haven, Connecticut, 06520, United States

Contact Email: •••••@•••••

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