New hope for kids with relapsed cancers: experimental drug CBL0137 enters trial
NCT ID NCT04870944
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the best dose, check side effects, and see if the drug can shrink tumors. The drug works by blocking signals inside cancer cells that help them grow and survive.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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C S Mott Children's Hospital
RECRUITINGAnn Arbor, Michigan, 48109, United States
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Children's Healthcare of Atlanta - Arthur M Blank Hospital
RECRUITINGAtlanta, Georgia, 30329, United States
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Children's Hospital Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
RECRUITINGLos Angeles, California, 90027, United States
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Children's Hospital of Alabama
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Email: •••••@•••••
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Children's Hospital of Orange County
RECRUITINGOrange, California, 92868, United States
Contact Email: •••••@•••••
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Email: •••••@•••••
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Children's Hospital of Pittsburgh of UPMC
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
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Children's Hospital of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
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Children's Mercy Hospitals and Clinics
RECRUITINGKansas City, Missouri, 64108, United States
Contact Email: •••••@•••••
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Children's National Medical Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Email: •••••@•••••
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Cook Children's Medical Center
RECRUITINGFort Worth, Texas, 76104, United States
Contact Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Duke University Medical Center
RECRUITINGDurham, North Carolina, 27710, United States
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Johns Hopkins All Children's Hospital
RECRUITINGSt. Petersburg, Florida, 33701, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
RECRUITINGBaltimore, Maryland, 21287, United States
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Lurie Children's Hospital-Chicago
RECRUITINGChicago, Illinois, 60611, United States
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
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New York Medical College
RECRUITINGValhalla, New York, 10595, United States
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Oregon Health and Science University
RECRUITINGPortland, Oregon, 97239, United States
Contact Email: •••••@•••••
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Phoenix Childrens Hospital
RECRUITINGPhoenix, Arizona, 85016, United States
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Primary Children's Hospital
RECRUITINGSalt Lake City, Utah, 84113, United States
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Riley Hospital for Children
RECRUITINGIndianapolis, Indiana, 46202, United States
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
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Saint Jude Children's Research Hospital
RECRUITINGMemphis, Tennessee, 38105, United States
Contact Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
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Sydney Children's Hospital
SUSPENDEDRandwick, New South Wales, 2031, Australia
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UCSF Medical Center-Mission Bay
RECRUITINGSan Francisco, California, 94158, United States
Contact Email: •••••@•••••
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UT Southwestern/Simmons Cancer Center-Dallas
RECRUITINGDallas, Texas, 75390, United States
Contact Email: •••••@•••••
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University of Chicago Comprehensive Cancer Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Minnesota/Masonic Cancer Center
RECRUITINGMinneapolis, Minnesota, 55455, United States
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Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Experimental antibody drug shows promise for Hard-to-Treat lymphoma
- Glowing dye could help surgeons spot hidden brain tumor cells
- Engineered immune cells target deadly brain tumors in children
- Vaccine trains immune system to hunt down cancer cells
- Targeted drug aims to shrink recurrent brain tumors by blocking key growth enzyme
- Scientists seek tissue samples to unlock HIV-Cancer mysteries