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Glowing dye could help surgeons spot hidden brain tumor cells

NCT ID NCT04743310

Completed Diagnosis Sponsor: John Yu Source: ClinicalTrials.gov ↗

First seen Jul 10, 2026 · Last updated Jul 10, 2026

Summary

This study tests whether a fluorescent dye called tozuleristide, given before surgery, can make brain tumor tissue glow under a special imaging system. Surgeons can then see and remove more of the tumor while sparing healthy brain. The trial enrolls adults with certain types of brain tumors who are scheduled for surgery. The goal is to see how accurately the dye identifies tumor tissue and whether it helps achieve more complete removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
tozuleristide
What this could lead to
If successful, this approach could help surgeons remove brain tumors more completely by making tumor tissue glow during surgery.
What could go wrong
This is a small, early-phase study. The dye may not work for all tumor types, and there is a risk of allergic reaction or other side effects. The technique may not improve patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acoustic neuroma astrocytoma (excluding glioblastoma) brain cancer central nervous system cancer craniopharyngioma ependymoma glioblastoma glioma medulloblastoma meningioma Neoplasms, Germ Cell and Embryonal Pinealoma primary brain neoplasm spinal cord neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CENTRAL NERVOUS SYSTEM TUMOR

Contacts and locations

Locations

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.