New hope for kids with deadly brain cancer? drug ONC206 enters human trials
NCT ID NCT04732065
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase trial tests a new drug called ONC206 in children and young adults with diffuse midline glioma or other recurrent brain tumors. The drug aims to kill cancer cells by causing stress in them, without harming healthy cells. Researchers are looking for the safest dose and checking for side effects, with up to 208 participants.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ONC206
- What this could lead to
- If successful, this could point toward a new treatment option for children with aggressive brain tumors like diffuse midline glioma.
- What could go wrong
- This is an early phase 1 trial, so the drug may not work or could have side effects. It is small and focused on safety, not yet proving effectiveness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Princess Máxima Center for Pediatric Oncology
RECRUITINGUtrecht, 3584, Netherlands
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The University Children's Hospital in Zurich
RECRUITINGZurich, Canton of Zurich, 8032, Switzerland
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New imaging clues could sharpen brain tumor monitoring
- Can a virus injected into brain tumors fight recurrence?
- Can a Tumor's genetic blueprint guide better treatment for kids with brain cancer?
- Can a seizure drug outsmart a deadly brain tumor?
- A simple lotion duo may shield skin from Tumor-Treating fields
- Can a One-Two punch slow recurrent brain cancer?