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Can a One-Two punch slow recurrent brain cancer?

NCT ID NCT02761070

Completed Disease control Sponsor: Kyorin University Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 07, 2026

Summary

This phase III trial compares two treatment strategies for people whose glioblastoma, an aggressive brain cancer, has returned or progressed after initial therapy. One group receives bevacizumab alone, while the other receives dose-dense temozolomide followed by bevacizumab if the tumor worsens. The study aims to see if the sequential approach improves overall survival compared to bevacizumab alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
bevacizumab and temozolomide
What this could lead to
If successful, this could establish a new standard treatment sequence for recurrent glioblastoma, potentially extending survival.
What could go wrong
The trial is in a challenging disease where many treatments fail; benefits may be modest, and both drugs carry risks like bleeding and fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Disease Progression glioblastoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA PROGRESSION RECURRENCE

Contacts and locations

Locations

  • Chiba University Hospital

    Chiba, Chiba, 260-8677, Japan

  • Dokkyo Medical University

    Shimotsuge, Tochigi, 321-0293, Japan

  • Ehime University Graduate School of Medicine

    Shizukawa, Ehime, 791-0295, Japan

  • Fujita Health University Hospital

    Toyoake, Aichi-ken, 470-1192, Japan

  • Hirosaki University School of Medicine

    Hirosaki, Aomori, 036-8563, Japan

  • Hiroshima University Hospital

    Hiroshima, 734-8551, Japan

  • Hokkaido University Graduate School of Medicine

    Sapporo, 060-8648, Japan

  • Iwate Medical University

    Morioka, Iwate, 020-8505, Japan

  • Kagoshima University Graduate School of Medical and Dental Sciences

    Kagoshima, 890-8520, Japan

  • Kansai Medical University

    Hirakata, Osaka, 573-1191, Japan

  • Keio University Hospital

    Tokyo, 160-8582, Japan

  • Kitasato University School of Medicine

    Kanagawa, 252-0374, Japan

  • Kobe University Hospital

    Kobe, Hyōgo, 650-0017, Japan

  • Kumamoto University Hospital

    Kumamoto, Kumamoto, 860-8556, Japan

  • Kurume University Hospital

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Kusyu University Graduate School of Medical Sciences

    Fukuoka, 812-8582, Japan

  • Kyorin University Faculty of Medicine, Department of Neurosurgery

    Tokyo, 181-8611, Japan

  • Kyoto University Graduate School of Medicine

    Kyoto, 606-8507, Japan

  • Nagasaki University Hospital

    Nagasaki, Nagasaki, 852-8501, Japan

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • Nakamura Memorial Hospital

    Sapporo, 060-8570, Japan

  • National Cancer Center Hospital

    Tokyo, 104-0045, Japan

  • Nihon University School of Medicine Itabashi Hospital

    Tokyo, 173-0032, Japan

  • Niigata University Medical & Dental Hospital

    Niigata, Niigata, 951-8520, Japan

  • Okayama University Hospital

    Okayama, Okayama-ken, 700-8558, Japan

  • Osaka International Cancer Institute

    Osaka, 541-8567, Japan

  • Osaka University Graduate School of Medicine

    Suita, Osaka, 565-0871, Japan

  • Saga University Hospital

    Saga, Saga-ken, 849-8501, Japan

  • Saitama Medical University International Medical Center

    Hidaka, Saitama, 350-1298, Japan

  • Sapporo Medical University Hospital

    Sapporo, Hokkaido, 060-8543, Japan

  • Shizuoka Canser Center Hospital

    Shizuoka, 411-8777, Japan

  • The University of Tokyo Hospital

    Tokyo, 113-8655, Japan

  • Tohoku University Graduate School of Medicine

    Sendai, Miyagi, 980-8574, Japan

  • Tokyo Medical And Dental University, Medical Hospital

    Bunkyō-Ku, Tokyo, 113-8519, Japan

  • University of Tsukuba Hospital

    Tsukuba, Ibaraki, 305-8576, Japan

  • University of Yamanashi

    Chuo-shi, Yamanashi, 400-8510, Japan

  • Yamagata University Hospital

    Yamagata, Yamagata, 990-9585, Japan

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