CENTRAL NERVOUS SYSTEM TUMOR

This study tests whether a machine learning tool can accurately predict which patients are at high risk for infection after brain or spinal tumor surgery. About 500 adults scheduled for surgery will have their infection risk calculated within 72 hours after the operation. High-ri…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This early-phase study tests a combination of two drugs, avutometinib and defactinib, in children and young adults (ages 3 to 30) with solid tumors that have returned or not responded to treatment. The main goal is to find a safe dose with manageable side effects. The drugs targe…

This study tests an experimental drug called ONC206, alone or with radiation, in children and young adults with a rare and aggressive brain tumor called diffuse midline glioma (DMG) or other recurring brain cancers. The goal is to find the best dose and see if it is safe. ONC206 …

This program gives children and young adults with central nervous system or head and neck tumors access to a special PET scan that uses a tracer called methionine. The scan helps doctors see the tumor more clearly and make better treatment decisions. Anyone under care at St. Jude…

This study looks at 50 twins where only one child has a central nervous system tumor. Researchers will compare DNA from blood and saliva samples to see if small genetic differences (called somatic mosaicism) explain why one twin gets cancer and the other stays healthy. The goal i…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to provide researchers with a powerful tool to study what causes cancer, how it progresses, and …

This study is testing whether an artificial intelligence (AI) tool can help match people with advanced cancer to the right clinical trials. Researchers will enroll up to 50,000 participants to see if the AI improves trial enrollment rates and patient outcomes. The goal is to make…

This study collects leftover tumor tissue from surgery or autopsy from 500 people with central nervous system (CNS) tumors. Researchers will use the tissue to create cell lines and models to test how different drugs work. The goal is to learn more about these tumors and find bett…