CENTRAL NERVOUS SYSTEM TUMOR

This is a first-in-human study to find the safest dose of a new oral drug called ONC206 for children and young adults with aggressive brain tumors, including a type called diffuse midline glioma (DMG). The trial will test the drug alone or in combination with radiation therapy in…

This study is testing the safety of a new two-drug combination (avutometinib and defactinib) for children and young adults (ages 3-30) whose solid tumors have come back or stopped responding to standard treatments. The main goal is to find the highest dose that is safe and causes…

This study is testing a new computer tool that predicts which patients are at high risk for a wound infection after brain or spine tumor surgery. About 500 patients will have their risk calculated after surgery. Those flagged as high-risk will get extra preventive care to see if …

This early-stage study is testing a new cell therapy for children and young adults with aggressive or returning brain tumors. Doctors collect a patient's own immune cells, engineer them in a lab to target a protein (B7H3) found on tumor cells, and then deliver these 'CAR T cells'…

This program offers a special type of PET scan to children and young adults with known or suspected cancers in the brain, spine, or head/neck area. The scan uses a small, safe amount of a radioactive tracer that may help doctors see the cancer more clearly. The goal is to provide…

This study aims to collect leftover tissue from brain and spinal cord tumor surgeries, as well as from autopsies, to learn more about these cancers. Researchers will use the samples to grow tumor cells in the lab and test how they respond to different drugs. The goal is to find n…

This study aims to understand why one twin develops a childhood brain tumor while their identical twin does not. Researchers will collect blood and saliva samples from 25 pairs of identical twins in this situation. They will look for tiny genetic differences that might explain wh…

This study is testing a new artificial intelligence (AI) tool designed to help match people with advanced cancer to suitable clinical trials. It will enroll up to 50,000 patients to see if using this AI system makes it easier for patients to find and join trials. The researchers …

This study is building a large, long-term database of health information and biological samples from people with cancer, people at risk for cancer, and healthy volunteers. The goal is to collect this data to help researchers better understand what causes cancer and how to prevent…