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Engineered immune cells take aim at childhood brain cancers

NCT ID NCT04185038

Recruiting now Disease control Sponsor: Seattle Children's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tests whether a new type of immunotherapy, called B7-H3 CAR T cells, can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG, DMG, or other recurrent central nervous system cancers. The treatment uses the patient's own immune cells, which are modified in a lab to recognize and attack tumor cells. The goal is to see if this approach is safe and feasible, and to gather early information on how the cells spread and work in the body.

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Conditions

The condition(s) this trial relates to.

atypical teratoid rhabdoid tumor brain cancer central nervous system cancer childhood medulloblastoma choroid plexus carcinoma diffuse intrinsic pontine glioma ependymoma germ cell tumor glioma medulloblastoma Neoplasms, Germ Cell and Embryonal Neuroectodermal Tumors, Primitive Pinealoma pineoblastoma primitive neuroectodermal tumor rhabdoid tumor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL TERATOID/RHABDOID TUMOR CENTRAL NERVOUS SYSTEM TUMOR CHOROID PLEXUS CARCINOMA DIFFUSE INTRINSIC PONTINE GLIOMA DIFFUSE MIDLINE GLIOMA EPENDYMOMA GERM CELL TUMOR GLIOMA MEDULLOBLASTOMA, CHILDHOOD PINEOBLASTOMA, CHILDHOOD PRIMITIVE NEUROECTODERMAL TUMOR

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Seattle Children's Hospital

    RECRUITING

    Seattle, Washington, 98105, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact