Can a sharper beam of radiation shield the mind during brain tumor treatment?

NCT ID NCT07750457

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial is testing whether proton therapy, a more precise form of radiation, can better preserve memory and thinking skills compared to standard photon radiation in people with slow-growing brain tumors (grade 2 or 3 gliomas). Participants will be randomly assigned to receive either proton or photon radiation, and their cognitive function will be tracked for several years. The goal is to see if the more targeted approach reduces damage to healthy brain tissue and helps maintain quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Proton therapy (a type of radiation that may spare healthy brain tissue) compared to standard photon radiation therapy
What this could lead to
If proton therapy better preserves thinking and memory after brain radiation, it could become a preferred treatment option for people with low-grade gliomas.
What could go wrong
This is a relatively small study, and the benefit is not guaranteed. Proton therapy may not significantly improve cognitive outcomes, and there are always risks from radiation itself.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Universitätsklinikum Essen

    RECRUITING

    Essen, Germany

  • Universitätsklinikum Gießen und Marburg

    RECRUITING

    Giessen, Germany

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