Can a sharper beam of radiation shield the mind during brain tumor treatment?
NCT ID NCT07750457
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This trial is testing whether proton therapy, a more precise form of radiation, can better preserve memory and thinking skills compared to standard photon radiation in people with slow-growing brain tumors (grade 2 or 3 gliomas). Participants will be randomly assigned to receive either proton or photon radiation, and their cognitive function will be tracked for several years. The goal is to see if the more targeted approach reduces damage to healthy brain tissue and helps maintain quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Proton therapy (a type of radiation that may spare healthy brain tissue) compared to standard photon radiation therapy
- What this could lead to
- If proton therapy better preserves thinking and memory after brain radiation, it could become a preferred treatment option for people with low-grade gliomas.
- What could go wrong
- This is a relatively small study, and the benefit is not guaranteed. Proton therapy may not significantly improve cognitive outcomes, and there are always risks from radiation itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Universitätsklinikum Essen
RECRUITINGEssen, Germany
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Universitätsklinikum Gießen und Marburg
RECRUITINGGiessen, Germany
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