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Brain electrode recordings during awake surgery could sharpen tumor removal

NCT ID NCT05875935

Knowledge-focused Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 16, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study investigates whether recording brain electrical activity during awake surgery can help identify networks involved in thinking and language. In people with glial brain tumors located in critical functional areas, surgeons place electrode grids on the brain before waking the patient. By correlating these recordings with imaging data, researchers aim to map tumor and healthy tissue more precisely. The goal is to remove more of the tumor while reducing the risk of long-term neurological damage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
electrocorticography (ECoG) recording during awake surgery
What this could lead to
If successful, this approach could help surgeons remove brain tumors more completely while preserving cognitive functions, potentially improving survival and quality of life.
What could go wrong
This is a very small, early-stage study with only one participant, so results may not apply broadly. The technique is complex and may not translate into routine practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

1 person

The number who actually took part.

Started

Dec 2021

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Man or woman over 18 years-old * Subject with a non-recurrent glial lesion requiring surgery in vigilant condition; * Brain lesion located in the functional zone; * Major not protected within the meaning of the law; * Subject affiliated to a Health Insurance scheme; * No medical contraindication to performing an MRI (pacemaker); * No medical contraindication to surgery and anesthesia; * Karnofski index\> 70; * Subject having signed an informed consent. Exclusion Criteria: * Minor subject, pregnant or breastfeeding woman; * Major subject subject under measure of legal protection, guardianship or deprived of liberty by judicial or administrative decision; * Subject hospitalized without consent; * Subject treated with antipsychotics (neuroleptic or lithium); * Subject who has already been treated for his glial lesion by surgery and / or radiotherapy; * Subject refusing to sign an informed consent. * Subject wishing to discontinue participation in the study before completion; * Subject for which the surgical intervention and / or the ECoG recording could not be carried out after admission to the operating room (whatever the reason).

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Conditions

The condition(s) this trial relates to.

glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Electrocorticography GLIOMA Karnofski index

Contacts and locations

Locations

  • Clairval Private Hospital

    Marseille, Paca, 13009, France

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