GLIOMA

This early-phase study tests the safety of a specially engineered virus (M032) injected directly into the brain tumor of children and adults with diffuse midline glioma, a rare and aggressive cancer. Participants must have completed standard radiation therapy 4 to 8 weeks before …

This study tests whether a combination of three drugs—pembrolizumab, olaparib, and temozolomide—can safely shrink or control brain tumors (gliomas) that have returned or not responded to earlier treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or I…

This study tests capmatinib, a drug already approved for certain lung cancers, in adults with other rare cancers that have specific MET gene changes. About 30 participants will receive the drug to see if their tumors shrink or stop growing for at least 24 weeks. The goal is to fi…

This early-phase study tests a new treatment for people with recurrent high-grade brain tumors (astrocytomas). A specially designed virus carrying two 'suicide' genes is injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the sa…

This study tests a new way to deliver a cancer drug directly to the brain along with repeat radiation for people whose aggressive brain tumors have come back. The drug, cetuximab, targets a protein common on these cancer cells. The goal is to see if this combination can stop tumo…

This study tests a new way to give radiation to people with aggressive brain tumors (glioblastoma) who cannot have surgery. Instead of the usual 3-week course, doctors use a PET scan to find the most active tumor areas and deliver higher-dose radiation in just 1 or 2 weeks, along…

This early-phase study tests a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors (like melanoma, lung, or colon cancer) that have a specific BRAF gene change and have stopped responding to standard treatments. The drug is given alone or combined w…

This study tests if methimazole, a drug used for thyroid conditions, can help people with progressive glioblastoma (a serious brain cancer). Researchers will give different doses to find a safe and effective level. The goal is to see if the drug can slow tumor growth and improve …

This study tests a drug called entrectinib, already approved for certain lung and solid tumors, in people with rare cancers that have a specific genetic change called ROS1 fusion. About 30 adults, teens, and children with these rare cancers will receive the drug. Researchers will…

This study tests a two-step treatment for people with newly diagnosed high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to control…

This study follows 150 adults with a certain type of slow-growing brain tumor (grade 2 glioma with an IDH mutation) who are taking the drug vorasidenib after surgery. The main goal is to see how the treatment affects their quality of life, including symptoms like seizures. Resear…

This study tests a drug called mirdametinib in people with certain brain or spinal cord tumors (gliomas). The goal is to see if it is safe and can shrink tumors or improve symptoms. About 26 adults will take the drug and be monitored for response.

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, a serious brain cancer. About 32 adults whose tumor has come back after prior treatment will be randomly assigned to get Avastin alone or Avastin…

This study tests a combination of two drugs—ATRA and retifanlimab—in people with a specific type of brain tumor (IDH-mutant glioma) that has returned after prior treatment. The goal is to see if this combo can shrink tumors or slow their growth by boosting the body's immune respo…

This study tests a drug called safusidenib in people with a slow-growing brain tumor (glioma) that has a specific IDH1 gene mutation. The trial has three parts: one for recurrent tumors, one to see if the drug can prevent tumor growth after standard treatment, and one for a speci…

This study tests whether the drug ONC201 can help people with a rare and aggressive brain tumor called H3 K27M-mutant glioma live longer. Participants must have completed standard radiation therapy. The trial is double-blind, meaning neither patients nor doctors know who gets the…

This early study tests the safety and feasibility of combining four drugs (dasatinib, quercetin, fisetin, and temozolomide) for people with glioma that has residual disease after prior treatment. The goal is to see if this approach can be tailored to each patient. Ten adults with…

This early-stage study tests a treatment called TIL therapy for people with brain glioma who have not responded to standard treatments. Doctors take immune cells from the patient's own tumor, grow them in a lab, and put them back into the body to attack the cancer. The goal is to…

This early study tests the safety of a wearable device called Optune that creates low-intensity electric fields to disrupt cancer cell division. Ten adults with brainstem gliomas will wear the device to see if it can slow tumor growth or shrink the cancer. The goal is to find a n…

This early-stage study is testing whether specially engineered immune cells (CAR T cells) can be safely given directly into the brain or spinal fluid of children and young adults with aggressive brain tumors like DIPG or recurrent medulloblastoma. The cells are designed to recogn…

This study tests whether adding silevertinib (an oral targeted therapy) to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer growing. About 162 adults whose tumors have certain genetic markers (…

This study tests a special proton therapy technique that avoids the hippocampus, a brain area key for memory, in children with low-grade glioma. About 74 children will receive this treatment to see if it's possible to reduce radiation to the hippocampus while still controlling th…

This study tests two drugs, vemurafenib and cobimetinib, already approved for melanoma, in adults with other rare cancers that have a specific BRAF V600 gene change. About 30 people will take the drugs to see if their tumors shrink or stop growing. The goal is to find new uses fo…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard therapy. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to control the tumor and see if the combination is s…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or stop them from growing. Participants receive the drug through an IV every 3 weeks for up t…

This early-stage study tests whether using sound waves (NaviFUS system) can help the drug bevacizumab work better for people with recurrent glioblastoma, an aggressive brain cancer. About 10 adults whose cancer has returned after standard treatments will receive the drug plus sou…

This early-stage study tests an experimental oral drug, NST-628, in adults with advanced solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to check the drug's safety, find the right dose, and see if it shrinks tumors. About 230 participants w…

This early-stage trial tests a special helmet that uses sound waves to temporarily open the blood-brain barrier, allowing chemotherapy to better reach aggressive brain tumors called glioblastoma. Ten adults who have already completed initial treatment will receive the helmet trea…

This study tests a new experimental drug (PF-07799544) combined with another drug (PF-07799933) in adults with advanced solid tumors that have a specific gene change called BRAF V600. The goal is to see if the combination is safe and can shrink or control the cancer. Participants…

This study tests a combination of two drugs, tarlatamab and temozolomide, in teens and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink or control the tumors. About 70 people will take part, …

This early-phase study tests an experimental oral drug called GLIX1 in 30 adults whose aggressive brain tumor (high-grade glioma) has come back or worsened after standard treatments. The main goals are to find a safe dose and check for any signs that the drug can control the dise…

This study tests a shorter, more intense radiation schedule for people whose glioblastoma (a severe brain cancer) has returned after standard treatment. About 28 adults will receive radiation 4 times a week for 1 to 3 weeks. The goal is to find the safest dose that controls the t…

This study tests a new radioactive drug, 177Lu-PSMA-617, to see if it is safe for people with a fast-growing type of brain tumor called IDH wild type glioma. The drug targets a protein (PSMA) found on these tumor cells and delivers radiation directly to them. About 20 adults whos…

This early-phase trial tests a personalized vaccine called Tamavaq NeoVaccine in 29 adults with newly diagnosed glioma, a type of brain cancer. The vaccine is custom-made using AI and quantum mechanics to target unique mutations in each patient's tumor. The main goal is to check …

This study is testing whether adding a new experimental medicine called APG-157, taken as dissolving pastilles in the mouth, can improve outcomes for people whose high-grade glioma (a type of aggressive brain tumor) has returned after previous treatment. Participants will take th…

This study tests a new type of PET/MRI scan that looks for a specific gene change (IDH mutation) in brain tumors called gliomas. Knowing this mutation helps doctors choose the right treatment and predict outcomes. The trial will enroll 10 adults with suspected or known gliomas to…

This study is testing whether a special PET-MRI scan using 18F-Fluciclovine can help doctors tell the difference between actual tumor growth and harmless changes that happen after treatment in children with high-grade glioma. About 30 children aged 1 to 21 with this type of brain…

This study compares a new MRI technique (aMRI) to standard PET scans for measuring brain tumor activity in 20 adults with glioma. aMRI uses special analysis of regular MRI images to detect tumor cell metabolism without radiation. If it works as well as PET, it could offer a cheap…

This study is testing whether a special PET/CT scan can help doctors find and diagnose tumors in people with certain diseases, including amino acid transport disorders, primary hyperparathyroidism, and glioma. The scan looks at how the body handles amino acids to spot suspicious …

This study tests a special MRI technique that uses a natural substance (pyruvate) to see if it can better detect brain tumors called gliomas. Up to 5 adults with suspected or known gliomas will get this extra scan before surgery. The goal is to see if the new MRI is safe and more…

This study tests a special MRI technique called magnetic resonance elastography (MRE) that measures how stiff or soft brain tissue is. The goal is to see if MRE can tell the difference between tissue damaged by radiation and tumor that has come back in people with gliomas. About …

This study is testing a special MRI scan that uses a substance called hyperpolarized carbon to take clearer pictures of brain tumors (gliomas). The goal is to see if this method is safe and can help doctors find and diagnose these tumors better. About 140 adults with glioma will …

This study is testing whether artificial intelligence (AI) can accurately predict important molecular changes in gliomas, a type of brain tumor, by analyzing digital pathology images. Researchers will compare the AI's predictions against standard laboratory test results from 2,00…

This study tests a new program that gives brain tumor patients an information guide and one-on-one coaching sessions to help them cope after diagnosis. Researchers want to see if the program is practical and helpful for patients. About 50 adults recently diagnosed with a malignan…

This study tests whether the antidepressant escitalopram can improve memory, focus, and overall thinking in people newly diagnosed with a fast-growing brain cancer (grade IV glioma). About 20 participants will take the drug for 17 weeks and complete thinking and mood tests. The g…

This study looks at whether measuring the stiffness and stickiness of brain tumors (gliomas) using a special MRI technique called magnetic resonance elastography can help doctors better understand the tumor's behavior. About 100 adults with glioma will have this scan before surge…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study looks at platelets (small blood cells) found in brain and spinal cord tumors. Researchers want to see if platelets help tumors grow or spread, and if their presence is linked to patient survival. About 50 adults having tumor surgery will donate a small piece of their t…

This study looks at how olutasidenib, a drug for certain cancers with an IDH1 mutation, changes the way the body processes other medications. Researchers will give participants a mix of test drugs before and during olutasidenib treatment to measure differences in drug levels. The…

This trial tests whether a mobile app can help people with glioma (a type of brain tumor) receive their cancer treatment and monitoring at home instead of traveling to a specialist center. The study will enroll 120 adults who are starting or continuing systemic therapy. The main …

This study looks at whether early telehealth visits can help patients with aggressive brain tumors (high-grade glioma) discuss and document their end-of-life wishes soon after diagnosis. About 50 patients and their families will take part. The goal is to see if these visits are p…

This study aims to understand how patients with a slow-growing brain tumor (IDH-mutant grade 2 glioma) feel during different treatments. Researchers will compare quality of life, symptoms, and anxiety in patients receiving radiotherapy, the drug vorasidenib, or no active treatmen…

This study is testing whether a special PET-MRI scan using a tracer called 18F-Fluciclovine can better monitor low-grade gliomas (a type of brain tumor) in children and young adults. About 30 participants will get the scan before starting treatment, then again at 3 months and 1 y…

This study is testing whether a small device called a microdialysis catheter can safely collect fluid samples from brain tumors during surgery. The goal is to measure biomarkers—natural substances that show how the tumor behaves. Researchers hope this information will lead to bet…

This study analyzes tumor tissue from up to 12,000 cancer patients to find gene changes (mutations). The goal is to match each patient with a clinical trial or therapy that targets their specific cancer type. Researchers will also build a database of mutations to help future pati…

This early-stage trial tests a new imaging method that uses a radioactive tracer to find immune cells (CD8+ T-cells) inside brain tumors. The goal is to see if this PET scan can show where immune cells are active without needing a biopsy. About 20 adults with brain tumors schedul…

This study looks at how a type of brain tumor (parietal lobe glioma) affects a person's ability to pay attention to space and objects. Researchers will test 40 patients before and after surgery to see how these skills change. The goal is to better understand these thinking proble…

This study looks at how brain tumors (gliomas) may change over time and whether advanced MRI and PET scans can spot those genetic changes without repeated biopsies. About 20 adults with suspected or confirmed glioma will have imaging before surgery, and the results will be compar…

This early study tests a new graphene-based electrode for brain mapping during surgery to remove brain tumors. Ten adults with glioma will have the device used alongside standard monitoring to check its safety and how well it records brain signals. Some participants who are awake…

This study tests whether advanced MRI scans can better predict which parts of a malignant glioma (brain tumor) are most likely to come back after treatment. Researchers will use these scans to design safer, more targeted radiation plans. About 135 adults with suspected or confirm…

This study tests whether a special ultrasound dye can help brain surgeons tell the difference between tumor tissue and healthy brain during glioma surgery. The goal is to remove as much tumor as possible. About 100 adults having standard brain tumor surgery will receive the contr…

This study is creating a huge database of brain tumor patients (70,000 people) to help doctors better understand and treat these cancers. Researchers will collect MRI scans, lab results, and health outcomes from people with gliomas and other brain tumors. The goal is to use this …

This study tests a special version of the cancer drug nivolumab that has a fluorescent dye attached, called nivo800. The dye makes the drug glow, so doctors can see where it collects in brain tumors during surgery. The goal is to learn if this is safe and helps surgeons see tumor…

This study looks at why some people with brain tumors (gliomas) develop dangerously low blood cell counts from the chemotherapy drug temozolomide. Researchers will analyze genes, gut bacteria, and other factors in 55 patients to find predictors. The goal is to help doctors identi…

This study is testing a new MRI technique called CEST that can measure the acidity (pH) inside brain tumors like gliomas and metastases. Researchers will scan 800 patients to see if pH levels can help predict where tumors might come back and how long patients survive. The goal is…

This study tests a new MRI technique to measure a chemical called 2HG in brain tumors (gliomas) without needing surgery. Researchers will compare MRI results with tissue samples from 30 adults who are already scheduled for tumor removal. The goal is to improve how doctors track a…

This study looks at why some childhood cancer survivors continue to have symptoms like fatigue, pain, and trouble sleeping. Researchers will ask 600 survivors aged 8-18 about their symptoms and collect stool samples to study gut bacteria. The goal is to find links between gut hea…

This study looks at how the latest brain tumor classification system (from 2021) helps doctors better understand and treat different types of brain tumors. Researchers will collect data from 1,650 patients to see if the new system groups patients more accurately and to create tre…

This study tests a faster, more detailed MRI technique called Magnetic Resonance Fingerprinting (MRF) to see if it can tell the difference between a brain tumor coming back and radiation-induced brain damage. About 60 adults who have had brain radiation, have new or untreated bra…

This study looks at whether follow-up care for people with rare tumors can be done just as well by a nurse remotely as by a doctor in person. About 88 adults recently diagnosed with a rare tumor will be randomly assigned to either in-person doctor visits or remote nurse check-ins…

This study aims to improve how brain tumors (gliomas) are diagnosed and treated by using advanced genetic testing. Researchers will analyze tumor samples from 1,000 participants to identify specific genetic changes and match them with targeted therapies. The goal is to provide mo…

This study is testing whether a mobile app called Iskhaa can help people with brain tumors do their own neurological exams at home. Participants will record videos of tasks like walking or speaking, and answer quality-of-life questions. The app's results will be compared to in-pe…

This study looks at how radiation therapy for brain tumors (gliomas) affects thinking and memory. Researchers will use special brain scans (resting-state fMRI) and thinking tests to find which brain networks are most sensitive to radiation. About 96 adults with glioma will partic…