New pill shows promise for Hard-to-Treat cancers with BRAF mutations
NCT ID NCT05355701
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 29 times
Summary
This early-phase study tests a new oral drug, PF-07799933, in people aged 16 and older with advanced solid tumors (like melanoma, lung, or colon cancer) that have a specific BRAF gene change and have stopped responding to standard treatments. The drug is given alone or combined with other medicines (binimetinib, cetuximab, or chemotherapy). The main goals are to check safety, find the right dose, and see if the drug shrinks tumors. Participants take the pills twice daily for up to about 2 years.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Brigitte Harris Cancer Pavilion
RECRUITINGDetroit, Michigan, 48202, United States
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CT Scan and Echo Only: Henry Ford Medical Center-Plymouth
RECRUITINGPlymouth, Michigan, 48170, United States
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
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Cleveland Clinic Taussig Cancer Center Investigational Pharmacy
RECRUITINGCleveland, Ohio, 44106, United States
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Clinical and Translational Research Center (CTRC)
RECRUITINGAurora, Colorado, 80045, United States
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DFCI Chestnut Hill
RECRUITINGNewton, Massachusetts, 02459, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Hadassah Medical Center
RECRUITINGJerusalem, 9112001, Israel
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Henry Ford Hospital
RECRUITINGDetroit, Michigan, 48202, United States
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Henry Ford Medical Center - Columbus
RECRUITINGNovi, Michigan, 48377, United States
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Highlands Oncology Group
RECRUITINGFayetteville, Arkansas, 72703, United States
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Highlands Oncology Group
RECRUITINGRogers, Arkansas, 72758, United States
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Highlands Oncology Group
RECRUITINGSpringdale, Arkansas, 72762, United States
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Jewish General Hospital
RECRUITINGMontreal, Quebec, H3T 1E2, Canada
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MSK David H. Koch Center for Cancer Care
RECRUITINGNew York, New York, 10021, United States
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MSK Monmouth
RECRUITINGMiddletown, New Jersey, 07748, United States
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McGill University Health Centre
RECRUITINGMontreal, Quebec, H4A 3J1, Canada
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Memorial Sloan Kettering Cancer Center
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Cancer Center 53rd street
RECRUITINGNew York, New York, 10022, United States
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Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2M9, Canada
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Providence Cancer Institute Franz Clinic
RECRUITINGPortland, Oregon, 97213, United States
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
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Rambam Health Care Campus
RECRUITINGHaifa, Ḥeifā, 3109601, Israel
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SCRI Oncology Partners
RECRUITINGNashville, Tennessee, 37203, United States
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START San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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Sarah Cannon Research Institute - Pharmacy
RECRUITINGNashville, Tennessee, 37203, United States
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Sheba Medical Center
RECRUITINGRamat Gan, 5262000, Israel
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Sourasky Medical Center
RECRUITINGTel Aviv, Central District, 6423906, Israel
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Sylvester Comprehensive Cancer Center
RECRUITINGMiami, Florida, 33136, United States
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The Ottawa Hospital - General Campus
RECRUITINGOttawa, Ontario, K1H 8L6, Canada
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TriStar Bone Marrow Transplant
RECRUITINGNashville, Tennessee, 37203, United States
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TriStar Centennial Medical Center - Cell Processing Lab
RECRUITINGNashville, Tennessee, 37203, United States
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TriStar Centennial Medical center
RECRUITINGNashville, Tennessee, 37203, United States
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UCHealth Sue Anschutz-Rodgers Eye Center
RECRUITINGAurora, Colorado, 80045, United States
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University Health Network
RECRUITINGToronto, Ontario, M5G 2C4, Canada
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University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)
RECRUITINGAurora, Colorado, 80045, United States
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University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP)
RECRUITINGAurora, Colorado, 80045, United States
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University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP)
RECRUITINGAurora, Colorado, 80045, United States
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University of Miami Hospital and Clinics
RECRUITINGMiami, Florida, 33136, United States
Conditions
Explore the condition pages connected to this study.