Double attack on mutant KRAS: can two targeted drugs outsmart resistant cancers?

NCT ID NCT05288205

Recruiting now Disease control Sponsor: Allist Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether combining two experimental drugs, JAB-21822 and JAB-3312, can safely shrink or control advanced solid tumors that carry a specific KRAS G12C mutation. The study includes people with cancers like non-small cell lung, colorectal, or pancreatic cancer who have run out of standard options. The goal is to find the best dose and see how well the combination works against these hard-to-treat tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: A combination of two experimental targeted drugs: JAB-21822 (a KRAS G12C inhibitor) and JAB-3312 (an SHP2 inhibitor)
What this could lead to: If this combination works, it could offer a new treatment option for people with advanced cancers that carry a specific KRAS mutation, potentially shrinking tumors and slowing disease progression.
What could go wrong: This is an early-phase trial, so the safety and effectiveness are not yet proven. The combination may cause side effects or may not work for everyone. Success in this small study does not guarantee broader benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colorectal cancer colorectal neoplasm non-small cell lung carcinoma pancreatic ductal adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL CANCER KRAS P.G12C NON-SMALL CELL LUNG CANCER PANCREATIC DUCTAL CARCINOMA

Contacts and locations

Locations

Beijing Cancer Hospital
RECRUITING

Beijing, Beijing Municipality, 100142, China
Beijing Chest Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 101125, China
Beijing Tiantan Hospital, Captal Medical University
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100070, China
Cancer Hospital Chinese Academy Of Medical Sciences
RECRUITING

Beijing, Beijing Municipality, 100021, China
Cancer Hospital Chinese Academy Of medical Sciences Shenzhen Center
NOT_YET_RECRUITING

Shenzhen, Guangdong, 518116, China
Fudan University Shanghai Cancer Center
NOT_YET_RECRUITING

Shanghai, Shanghai Municipality, 200032, China
Fujian cancer Hospital
NOT_YET_RECRUITING

Fuzhou, Fujian, 350014, China
Harbin Medical University Cancer Hospital-Mammary gland of internal
NOT_YET_RECRUITING

Harbin, Heilongjiang, 150081, China
Henan Cancer Hospital
NOT_YET_RECRUITING

Zhengzhou, Henan, 450003, China
Hunan Cancer Hospital
NOT_YET_RECRUITING

Changsha, Hunan, 410031, China
LinYi Cancer Hospital
NOT_YET_RECRUITING

Linyi, Shandong, 276002, China
Pecking Union Medical College Hospital
NOT_YET_RECRUITING

Beijing, Beijing Municipality, 100005, China
Peking University Third Hospital
RECRUITING

Beijing, Beijing Municipality, 100191, China
Qilu Hospital of Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, 250012, China
Renmin Hospital Of Wuhan University
NOT_YET_RECRUITING

Wuhan, Hubei, 430060, China
Shandong Cancer Hospital
NOT_YET_RECRUITING

Jinan, Shandong, 250117, China
The Affilated Hospital of Inner Mongolia Medical University
NOT_YET_RECRUITING

Hohhot, Neimenggu, 750306, China
The First Affiliated Hosipital Of Zhengzhou University
NOT_YET_RECRUITING

Zhengzhou, Henan, 450052, China
The First Affiliated Hospital Xiamen University
NOT_YET_RECRUITING

Xiamen, Fujian, 361003, China
The First Affiliated Hospital of USTC Anhui Provincial Hospital
NOT_YET_RECRUITING

Hefei, Anhui, 230001, China
The First Hospital Of China Medical University
NOT_YET_RECRUITING

Shenyang, Liaoning, 110001, China
The Second Affiliated Hospital Zhejiang School of Medicine
NOT_YET_RECRUITING

Hangzhou, Zhejiang, 310009, China
The first Affiliated Hospital, Sun Yat-sen University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510080, China
Tongji Hospital Tongji Medical College of Hust
NOT_YET_RECRUITING

Wuhan, Hubei, 430030, China
Union Hospital Tongji Medical College Huazhong University of Science and Technology
NOT_YET_RECRUITING

Wuhan, Hubei, 430022, China
Xiangya Hospital Central South Univesity
NOT_YET_RECRUITING

Changsha, Hunan, 410008, China
Zhujiang Hospital of Southem Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510280, China

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