New 3-Drug cocktail targets Hard-to-Treat brain tumors

NCT ID NCT05188508

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tests whether combining pembrolizumab, olaparib, and temozolomide can shrink or slow the growth of gliomas that have come back after treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or III) will receive the drug combination. The goal is to see how many patients respond and to monitor side effects.

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Conditions

The condition(s) this trial relates to.

glioma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOMA

Contacts and locations

Locations

BAPTIST ALLIANCE - MCI (Data Collection Only)
RECRUITING

Miami, Florida, 33143, United States
Hartford Healthcare Alliance (Data Collection Only)
RECRUITING

Hartford, Connecticut, 06102, United States
Lehigh Valley Health Network (Data Collection Only)
RECRUITING

Allentown, Pennsylvania, 18103, United States
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk -Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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