Memorial Sloan Kettering Cancer Center

This study tests whether a bivalent vaccine, taken with a sugar called beta-glucan and a protein (GM-CSF), can help prevent high-risk neuroblastoma from returning in children who are currently in remission. The treatment works by training the immune system to recognize and attack…

This study tests a CAR T-cell therapy called obe-cel in adults with B-cell acute lymphoblastic leukemia (ALL) whose cancer is in complete remission with no detectable cancer cells. The goal is to see if obe-cel can prevent the cancer from coming back. About 40 participants will r…

This study tests whether adding the drug belumosudil to standard care can better prevent graft-versus-host disease (GVHD) in adults with blood cancer who have had a stem cell transplant. About 46 participants will receive belumosudil along with their usual GVHD prevention medicin…

This early-phase trial is testing an experimental drug called BMS-986504 alongside standard cancer treatments in 60 people with advanced cancers that have lost a gene called MTAP. The cancers include mesothelioma, stomach/esophageal cancer, and bladder cancer. The main goal is to…

This phase 2 trial is testing whether adding the immunotherapy drug pembrolizumab to standard GVD chemotherapy can improve outcomes for people with Hodgkin lymphoma that has returned or not responded to initial treatment. About 257 participants will receive up to 4 cycles of the …

This early-stage trial is testing whether adding an experimental cancer vaccine (ELI-002 7P) and an immunotherapy drug (tislelizumab) to standard chemotherapy (mFOLFIRINOX) is safe and effective for people with a specific type of pancreatic cancer that has a KRAS mutation. The st…

This study tests whether combining two oral drugs, abemaciclib and cabozantinib, is safe and effective for people with advanced clear cell or translocation kidney cancer that has already been treated with immunotherapy. The trial has two phases: first, finding the best dose with …

This early-phase study tests whether a short course of radiation (1 week instead of the usual 5) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The trial will enroll 28 participants and aims to see if mo…

This study tests a new drug called tinengotinib combined with standard hormone therapies (abiraterone or enzalutamide) in 50 men with metastatic castration-resistant prostate cancer that has spread and stopped responding to usual treatment. The goal is to see if the combination i…

This early-stage trial tests whether combining the drugs gilteritinib with ivosidenib or enasidenib is safe for people with acute myeloid leukemia (AML) that has returned or not responded to treatment. Participants must have specific gene mutations (FLT3 and IDH1 or FLT3 and IDH2…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control certain types of advanced thyroid cancer that no longer respond to standard radioactive iodine treatment. The trial enrolls 30 adults with RAF dimer-driven differentiated or anaplastic thyroid …

This early-stage trial tests a new treatment called CD371-YSNVZ-IL18 CAR T cells for people with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find the safest dose and see what side effects occur. About 15 participants w…

This study tests whether combining two drugs, revumenib and mezigdomide, is safe for people with specific types of acute leukemia that have returned or not responded to prior therapy. About 52 participants aged 12 and older will take part. The goal is to find the best dose and se…

This early-phase trial tests a drug called CRD3874-SI, which activates the STING pathway to boost the immune system's ability to fight cancer cells. It is for people with acute myeloid leukemia (AML) that has returned or not responded to previous treatments. The main goal is to f…

This phase 2 study is testing a time-limited combination of three drugs—pirtobrutinib, venetoclax, and rituximab—in 40 patients newly diagnosed with Waldenström's macroglobulinemia, a rare blood cancer. The goal is to see if this regimen can achieve a very good partial response o…

This study is for people with a specific type of lung cancer (EGFR-mutant NSCLC) that has spread to the brain. Researchers want to see if adding a precise, one-time radiation treatment (SRS) to the standard drug osimertinib is better than the drug alone at controlling brain tumor…

This study tests a drug called tarlatamab in people with a specific type of advanced prostate cancer (DLL3-positive) that has spread and either came back or didn't respond to prior treatments. About 32 participants will receive the drug to see if it can shrink tumors or slow the …

This early-phase study tests a new treatment for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment combines specially trained natural killer (NK) immune cells with a drug called atezolizumab. The main goal is to find a…

This Phase 2 trial is testing whether adding cyclophosphamide to elranatamab helps people with relapsed or refractory multiple myeloma who have risk factors that make standard treatment less effective. About 26 participants will receive the combination therapy. The main goal is t…

This study compares a new boost approach called irreversible electroporation (IRE) using the NanoKnife system against the standard radiation boost for men with intermediate-risk prostate cancer. All participants will receive standard stereotactic body radiation therapy (SBRT), bu…

This phase 1 trial tests a new therapy called MSK-TCR5 for people with advanced solid tumors that have a specific genetic change (RAS G12D mutation) and a certain immune type (HLA-A*11:01). The therapy uses a patient's own T-cells, modified in a lab to better recognize and attack…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, can shrink or eliminate rectal tumors in people with a specific type of rectal cancer (MMRp/MSS) that usually doesn't respond to immunotherapy alone. About 40 adults with stage II or III rectal cancer…

This study tests whether combining two drugs, tepotinib and ivonescimab, is safe and works for people with advanced non-small cell lung cancer that has a specific genetic change called METex14 skipping. About 16 participants will try different doses to find the one with the fewes…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink or control advanced or recurrent ER+ endometrial cancer. About 75 adults who have already had chemotherapy and immunotherapy will take part. The goal is to see how well the treatment works and if it i…

This early-phase trial tests two experimental drugs, ABBV-637 and ABBV-155, alone or together with ERAS-801 in people whose glioblastoma has come back after standard treatment. About 60 adults with a specific genetic marker (EGFR amplification) will take part. The main goal is to…

This study tests whether giving a personalized dose of the chemotherapy drug fludarabine before CAR T-cell therapy can improve outcomes for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia. About 130 participants will be randomly assign…

This early-phase study tests whether combining two drugs, epcoritamab and ibrutinib, is safe for people whose central nervous system lymphoma has come back or not responded to treatment. About 26 adults with this rare cancer will receive the drug combination. The main goal is to …

This study tests whether stereotactic radiosurgery (SRS), a precise form of radiation, can effectively treat brain metastases in people newly diagnosed with small cell lung cancer that has spread to the brain. About 62 participants will receive SRS, and researchers will track how…

This phase 2 trial tests whether giving a powerful chemotherapy regimen called NALIRIFOX along with targeted radiation and the drug capecitabine can shrink pancreatic tumors enough to allow successful surgery. The study enrolls 60 people with borderline resectable or locally adva…

This early-phase study tests whether combining valemetostat with atezolizumab is safe as maintenance therapy for people with extensive-stage small cell lung cancer. Researchers will try different doses of valemetostat to find the best one with few side effects. The study involves…

This study tests a new cancer drug, repotrectinib, combined with standard chemotherapy in children and young adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if the combination can shrink tumors. Researchers will also study how the b…

This study is testing a new treatment for older adults (65 and up) with diffuse large B-cell lymphoma (DLBCL) or similar aggressive lymphomas. The treatment combines a targeted immunotherapy drug called glofitamab with standard chemotherapy, aiming to improve cancer remission whi…

This early-phase study tests a radioactive drug called 177Lu-PSMA-617 combined with standard chemotherapy (temozolomide) for people with aggressive IDH wild type gliomas. The goal is to see if the combination is safe and to get a first look at whether it helps control tumor growt…

This Phase II trial tests a bivalent vaccine (with an immune booster) plus two different schedules of oral β-glucan in 94 people with high-risk neuroblastoma who are in complete remission. The goal is to see which schedule triggers stronger antibodies against the cancer, potentia…

This early-phase study tests a personalized cell therapy called MB-CART19.1 for people with central nervous system lymphoma (CNSL) that has returned or not responded to prior treatments. The therapy uses the patient's own immune cells, modified to attack the cancer, and is made o…

This study tests whether giving two drugs (enfortumab vedotin and pembrolizumab) before bladder cancer surgery can eliminate cancer in the lymph nodes and shrink tumors. About 23 adults with advanced bladder cancer that has spread to lymph nodes will receive the combination befor…

This study looks at whether giving hormone therapy before breast-conserving surgery helps reduce leftover cancer cells at the edges of removed tissue. It involves 176 postmenopausal women with stage 2-3 ER+/HER2- invasive lobular carcinoma. The goal is to see if this approach lea…

This study tests whether adding the drug cadonilimab to standard chemotherapy (FLOT) helps people with a certain type of stomach or gastroesophageal junction cancer that can be removed with surgery. About 37 adults will receive the combination before and after surgery. The goal i…

This early-phase trial tests the safety of CRD3874-SI, a drug that activates the STING pathway to boost the immune system against cancer. About 81 adults with advanced solid tumors (sarcoma, Merkel cell carcinoma, and others) will receive weekly IV infusions at increasing doses. …

This study compares the standard drug osimertinib alone versus osimertinib plus chemotherapy (carboplatin and pemetrexed) in people with metastatic EGFR-mutant lung cancer who still have detectable cancer DNA in their blood after starting osimertinib. The goal is to see if the co…

This study tests whether the drug Ivonescimab can safely shrink or control advanced leiomyosarcoma, a rare soft-tissue cancer. About 20 adults who have already tried 1-3 prior treatments will receive the drug. The goal is to see if it slows tumor growth with few side effects.

This study is testing a stem cell transplant from half-matched (haploidentical) donors for people with sickle cell disease or beta-thalassemia. Before the transplant, patients receive drugs to lower their immune system, which may reduce the risk of serious side effects like graft…

This study tests whether a personalized, lower dose of radiation (guided by a special PET scan) works as well as the standard dose for people with HPV-positive throat cancer. About 291 participants will receive either the lower or standard radiation dose, along with standard chem…

This study tests a radioactive drug called I-MIBG in people with resistant neuroblastoma or related tumors (pheochromocytoma and paraganglioma). The drug is designed to deliver radiation directly to cancer cells. Researchers want to see if it can shrink tumors and how safe it is.…

This study is for people who had surgery for oral tongue cancer and need radiation to prevent recurrence. Instead of radiating the whole mouth, doctors will only target the neck lymph nodes, sparing the tongue. The goal is to see if this reduces severe mouth sores while keeping t…

This early-stage trial tests a personalized cell therapy called lifileucel for people with advanced uveal melanoma (a rare eye cancer) or certain sarcomas (connective tissue cancers). The treatment involves removing immune cells from the patient's tumor, growing them in a lab, an…

This study tests a drug called ulixertinib for people with histiocytic neoplasms, a rare group of disorders where immune cells form tumors. The drug is taken as a pill twice daily. Researchers want to see if it can shrink tumors and control the disease. The trial will enroll 38 a…

This phase 2 study is testing whether adding two newer drugs—pembrolizumab (an immunotherapy) and trastuzumab (a targeted therapy)—to standard chemotherapy can help people with HER2-positive esophageal or stomach cancer that can be surgically removed. About 49 adults will receive…

This early-stage trial tests the drug abemaciclib (a CDK4/6 inhibitor) given together with targeted radiation for people with metastatic HR+ HER2- breast cancer that has spread to bone. The main goal is to find the safest dose of abemaciclib when combined with radiation. About 28…

This study tests a drug called sacituzumab govitecan in 33 adults with mesothelioma that has come back or spread. Participants receive the drug until their disease worsens or side effects become too severe. The main goal is to see if the drug can shrink tumors and help control th…

This study tests whether switching to the drug ruxolitinib after a stem cell transplant can better prevent chronic graft-versus-host disease (GVHD) compared to standard treatment. About 40 adults with blood cancers who are in remission will receive either a medium dose of cycloph…

This study tests whether time-restricted eating (eating only during a set window each day) combined with regular coaching calls can help adult survivors of childhood cancer lose weight and lower their risk for heart disease and diabetes. Three hundred survivors with a BMI of 25 o…

This study tests whether a combination of two non-chemotherapy drugs (vemurafenib and obinutuzumab) causes fewer side effects than the standard chemotherapy-based treatment (cladribine and rituximab) in people with untreated hairy cell leukemia. About 86 adults with a specific ge…

This early-phase study tests a combination of two drugs, alectinib and duvelisib, in 30 people with a rare type of blood cancer called ALK-positive anaplastic large cell lymphoma that has come back or not responded to prior treatment. The goal is to find a safe dose and see if th…

This early-stage trial is testing whether the drug sotorasib can get into KRAS G12C+ brain tumors and how safe and effective it is. Sixteen adults with these tumors who are already scheduled for brain surgery will receive the drug. Researchers will measure how much drug reaches t…

This phase 2 trial tests a personalized approach for people with HER2+ metastatic breast cancer. Doctors use ctDNA blood tests and imaging to decide when to step up or down treatments, including targeted drugs and local therapies, to achieve long-term remission. The goal is to se…

This study tests whether combining two drugs, mirdametinib and palbociclib, can safely slow or stop advanced liposarcoma (a rare soft-tissue cancer). About 54 adults with liposarcoma that has spread or cannot be removed will receive different doses to find the best one. The main …

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune response to the drug pembrolizumab in people with metastatic or locally advanced triple negative breast cancer. About 30 participants will be randomly assigned to receive either the combinat…

This phase 2 trial tests the drug mosunetuzumab, alone or with zanubrutinib, in 152 adults with newly diagnosed follicular lymphoma who need treatment. The goal is to see how many patients achieve complete remission. Participants receive the drug as injections over several months…

This study tests whether using a fluorescent dye and special camera during ovarian cancer surgery can help surgeons see blood flow in the bowel and reduce the risk of leaks after reconnecting it. About 310 women with ovarian cancer who need bowel surgery will be randomly assigned…

This study tests whether the drug ivonescimab, given after standard radiation therapy (SBRT), can help prevent early-stage non-small cell lung cancer from returning. About 36 people with tumors up to 7 cm will receive the drug as a consolidation treatment. The main goal is to see…

This study tests whether adding surgery and targeted radiation to standard treatment helps people with HER2-positive breast cancer that has spread to up to 5 spots in the body. About 178 adults will be randomly assigned to receive either standard care alone or standard care plus …

This phase 2 trial tests whether a combination of three drugs—fianlimab, cemiplimab, and ipilimumab—can safely shrink tumors in people with advanced melanoma that no longer responds to standard PD-1 therapy. The study enrolls 88 adults with locally advanced or metastatic melanoma…

This study is testing a drug called pembrolizumab in people with ultra-rare sarcomas, a group of very uncommon cancers. The drug works by releasing the immune system's brakes so it can attack cancer cells. Researchers want to see if it can shrink tumors or stop them from growing,…

This study tests a drug called mirdametinib for people with certain brain or spinal cord tumors (gliomas). The goal is to see if it is safe and can shrink tumors or improve symptoms. About 26 adults will take part, and the drug targets tumors with specific genetic changes.

This study is testing whether the immunotherapy drug dostarlimab (TSR-042), followed by standard chemoradiation and surgery, can effectively treat advanced mismatch repair deficient (dMMR) solid tumors. About 212 adults with locally advanced dMMR cancers will receive the drug int…

This study tests whether a precise type of radiation (SBRT) alone can control unfavorable intermediate-risk prostate cancer, avoiding the need for hormone therapy. About 215 participants will receive SBRT, with the radiation dose guided by a genetic test (Decipher) to personalize…

This study tests if a combination of three drugs (lenvatinib, pembrolizumab, and fulvestrant) is safe and works for people with ER-positive, HER2-negative breast cancer that has spread. About 54 adults whose cancer has not responded to other treatments will take part. The goal is…

This study is for women with a certain type of endometrial cancer (called MMR-D/MSI-H) who have already had surgery. It tests whether adding radiation and an immunotherapy drug called dostarlimab can help keep the cancer from coming back. About 62 participants will receive the co…

This study is testing whether a more aggressive approach to managing high blood pressure during breast cancer treatment can safely reduce the risk of heart damage. About 130 women with breast cancer who are receiving anthracycline chemotherapy will be randomly assigned to either …

This study tests whether a cord blood transplant can help children and young adults (up to age 26) with blood cancers like leukemia and lymphoma. Participants receive the transplant as their first or second treatment. The main goal is to see how many are cancer-free one year afte…

This study is testing whether a lower dose of radiation can effectively treat metastatic tumors that have a specific genetic change called an ATM mutation. The goal is to find the smallest effective dose to reduce side effects. About 45 adults with advanced cancer and an ATM muta…

This study tests if the drug enfortumab vedotin can safely and effectively shrink or eliminate high-grade urothelial carcinoma in the upper urinary tract before standard surgery. It includes 24 people who cannot take or choose not to take the chemotherapy drug cisplatin. The main…

This study is testing whether giving lower doses of radiation over a shorter time, along with standard chemotherapy, works as well as the usual higher radiation doses for people with HPV-positive throat cancer. About 74 participants will receive chemoradiation with drugs like cis…

This phase 2 trial tests whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy can shrink HER2-positive rectal tumors before surgery. About 37 adults with locally advanced rectal cancer will receive the drug combo for 6 weeks, then continue it wit…

This expanded access program offers L-MTP-PE, an investigational drug that activates white blood cells to fight cancer, to people with osteosarcoma. Eligible patients include those with newly diagnosed or relapsed osteosarcoma who have had surgery to remove all detectable cancer.…

This study compares different FDA-approved drugs for a type of bladder cancer that hasn't spread into the muscle. About 125 adults whose previous treatment with BCG didn't work will receive either a newer gene therapy or standard drugs. The goal is to see which treatment better p…

This Phase 2 trial is testing a combination of three drugs—zanubrutinib, obinutuzumab, and venetoclax—in people with previously untreated chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or mantle cell lymphoma (MCL). The goal is to see if the combo can make …

This early-stage study tests a new drug called 2141-V11 in people with a type of bladder cancer that hasn't responded to standard therapy. The drug is given directly into the bladder through a catheter or by injection into the tumor. The main goal is to see if it's safe and to fi…

This study looks at whether adding a precise radiation dose to liver tumors can make standard immunotherapy work better for people with stage IV non-small cell lung cancer. About 68 adults whose cancer has spread to the liver will either get standard drug therapy alone or standar…

This study looks at whether a specific diet can improve how well treatment works and how patients feel. About 220 people with newly diagnosed multiple myeloma will take part. Researchers will track treatment response and quality of life through questionnaires and medical tests.

This study is testing a precise type of radiation called IMPRINT for people whose thymic cancer has spread to the lining of the lung (pleura). The main goal is to see if this treatment is safe and causes only mild side effects, especially lung inflammation. About 36 participants …

This phase II trial is testing the drug selinexor in people with Wilms tumor, rhabdoid tumor, MPNST, or other solid tumors that have returned or not responded to treatment. Selinexor works by blocking a protein called XPO1, which is often overactive in these cancers. The study ai…

This phase 2 trial tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). Th…

This study tests whether two drugs, avutometinib and defactinib, can shrink or control advanced or recurrent mesonephric gynecologic cancer, a rare type of cancer. About 40 women with persistent or recurrent disease will receive the drug combination. The main goal is to see how m…

This study tests whether adding siltuximab (a drug that blocks inflammation) to a personalized dose of melphalan chemotherapy works better than the standard melphalan dose in people over 60 with multiple myeloma receiving a stem cell transplant. About 215 participants will be ran…

This study compares standard chemotherapy (gemcitabine and oxaliplatin) alone versus the same drugs plus a liver-directed chemotherapy (HAI FUDR/dexamethasone) in people with bile duct cancer that has spread within the liver but cannot be removed surgically. About 164 adults with…

This phase 2 trial is testing whether a combination of drugs called BV-AVD works well for people with newly diagnosed, early-stage bulky Hodgkin lymphoma. The study uses PET scans to guide treatment and includes about 71 participants. The goal is to see if this approach can stop …

This study tests a combination of three drugs (avutometinib, defactinib, and letrozole) in 20 women with low-grade serous ovarian cancer who cannot have surgery right away. The goal is to see if the drugs can shrink tumors or control the cancer. Researchers will also monitor side…

This study tests whether combining the immunotherapy drug pembrolizumab with chemotherapy drugs (melphalan and dactinomycin) delivered directly to the affected limb via isolated limb infusion can safely delay cancer growth. It enrolls 30 patients aged 12 and older with advanced s…

This study is testing whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy can control HPV-positive throat cancer as well as the usual high dose (70 Gy). The goal is to reduce side effects from radiation while still keeping the cancer from coming bac…

This study tests whether combining the drug ivonescimab with either Dato-DXd or osimertinib is safe and effective for people with a specific type of advanced lung cancer (EGFR-mutant NSCLC) that has stopped responding to previous treatments. About 66 participants will receive dif…

This study tests the drug ruxolitinib in people with T or NK cell lymphoma that has come back or not responded to prior treatment. Ruxolitinib works by blocking a protein called JAK, which helps these cancer cells survive. The goal is to see if the drug can shrink tumors or contr…

This study tests a new drug called ivonescimab, given with standard chemotherapy and focused radiation (SRS), for people with non-small cell lung cancer that has spread to the brain. The goal is to find the safest dose and see if it helps control the brain tumors. About 53 adults…

This study tests whether a daily pill called isoquercetin, made from a plant compound, can reduce blood markers linked to clot risk in people with ovarian cancer. About 90 participants receiving chemotherapy will take either isoquercetin or a placebo for up to 6 weeks. The goal i…

This study tests whether giving a precise, high-dose radiation treatment called SBRT to one growing tumor can help people with metastatic breast cancer keep their disease under control. Participants continue their usual drug therapy while receiving SBRT to a single site where can…

This study tests a combination of four drugs (CyBorD plus daratumumab) in 20 people with a rare kidney condition caused by abnormal proteins. The goal is to see if the treatment is safe and can improve kidney function. Participants must have a confirmed diagnosis of multiple myel…

This study tests a new drug called 2141-V11, which helps the immune system find and kill prostate cancer cells. It is given as an injection into the tumor, either alone before surgery for intermediate-risk cancer or combined with hormone therapy for high-risk or early metastatic …

This study tests whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and effective for people with advanced soft tissue sarcoma that cannot be removed by surgery. About 98 participants will receive the…

This study is testing whether a blood test that detects HPV DNA can help doctors decide who needs radiation after surgery for HPV-related oropharynx cancer. In one group, patients with no detectable HPV DNA after surgery will be watched closely and only get radiation if the test …

This study tests a combination of two drugs—lorlatinib (a daily pill) and ramucirumab (an IV infusion every three weeks)—in people with advanced ALK-rearranged non-small cell lung cancer. The first part finds the safest dose, and the second part checks if that dose helps keep the…

This early-phase trial tests two drugs, ruxolitinib and duvelisib, together in people whose T- or NK-cell lymphoma has come back or stopped responding to treatment. The main goal is to find the safest dose of duvelisib when combined with a fixed dose of ruxolitinib. About 70 part…

This study tests enasidenib, a drug that targets cancer cells with a specific IDH2 mutation, in people with angioimmunoblastic T-cell lymphoma (AITL). The drug is given alone or with rituximab. The goal is to see if it safely shrinks tumors. About 25 adults whose lymphoma has ret…

This study is testing whether a lower dose of the drug brentuximab vedotin can still effectively treat three types of skin lymphoma: mycosis fungoides, Sezary syndrome, and lymphomatoid papulosis. The goal is to see if reducing the dose can maintain benefits while possibly loweri…

This study tests whether adding ulixertinib to the standard drug ruxolitinib is safe and helpful for people with myelofibrosis, a type of bone marrow cancer. About 37 adults who are already on a stable dose of ruxolitinib will receive different doses of ulixertinib. The goal is t…

This study tests a technique called acute normovolemic hemodilution (ANH) in 86 women having surgery for advanced ovarian cancer. Before surgery, some blood is removed and stored, then returned during or after the operation. The goal is to see if this reduces the need for donor b…

This early-stage study is testing whether adding the immunotherapy drug cemiplimab to standard chemotherapy and cetuximab before surgery is safe for people with advanced head and neck cancer. The goal is to see if this combination can control the cancer well enough that patients …

This early-phase trial tests whether deferoxamine, a drug given directly into the spinal fluid, is safe for people with leptomeningeal metastases—cancer that has spread to the lining of the brain and spinal cord. Researchers will test different doses in 35 adults with solid tumor…

This study tests a drug called sotorasib in people with advanced non-small cell lung cancer that has a specific change in the KRAS gene (called G12C). Participants have not yet received any treatment for their advanced cancer. The goal is to see if sotorasib is safe and effective…

This study tests a new drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD1 and VEGF) to help the immune system fight cancer and block tumor blood supply. Researchers wi…

This study tests a drug called enfortumab vedotin in people with adenoid cystic carcinoma (ACC), a rare cancer that has come back or spread. The goal is to see if the drug can shrink tumors or slow the disease. About 34 adults will take part, and researchers will monitor side eff…

This study tests whether adding four drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy helps people with osteosarcoma that has spread. About 45 participants with newly diagnosed or advanced disease will be enrolled. Researchers will check if the co…

This study tests a cord blood transplant in children and young adults (up to age 21) with life-threatening blood cancers or non-cancer blood disorders who do not have a matched family donor. The goal is to see if this approach lowers the risk of death from treatment one year afte…

This phase 2 trial is testing a drug called ZEN003694 in 13 people with advanced squamous cell lung cancer that has a specific gene change (NSD3 amplification). The drug works by blocking certain proteins that may help the cancer grow. Researchers want to see if it can shrink tum…

This study tests whether a new drug (BMS986365) combined with hormone therapy (degarelix) can safely shrink or eliminate high-risk prostate cancer before standard surgery. About 30 participants will receive the combination for several months, then have their prostate removed. The…

This study tests whether IgPro20 (HIZENTRA), a concentrated antibody solution given under the skin, can prevent infections in people with multiple myeloma who have low antibody levels due to bispecific antibody therapy. About 100 participants will either receive IgPro20 plus stan…

This early-phase study tests a new treatment called ADCLEC.syn1 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The main goal is to find a safe dose that causes few side effects, and then see if it can help control…

This study tests whether combining pembrolizumab, olaparib, and temozolomide can shrink or slow the growth of gliomas that have come back after treatment. About 57 adults with a specific type of glioma (IDH-mutated, grade II or III) will receive the drug combination. The goal is …

This study is testing whether a procedure called gastric preconditioning—done before esophageal cancer surgery—can lower the risk of a serious complication called an anastomotic leak. The procedure uses a tiny tube to redirect blood flow in the stomach, which may help the surgica…

This phase 2 study tests whether a three-drug combination (ivosidenib, azacitidine, and venetoclax) followed by maintenance therapy with ivosidenib alone can prevent acute myeloid leukemia (AML) from coming back in patients with an IDH1 mutation. The trial enrolls 45 people aged …

This study tests whether the drug talquetamab can improve outcomes for people with multiple myeloma who have already received a type of CAR T-cell therapy called ide-cel. All 17 participants will get talquetamab injections until their disease gets worse. The main goal is to see h…

This study tests a drug called pasireotide for people with prolactinomas (pituitary tumors) who cannot take standard dopamine agonist therapy due to side effects, resistance, or medical reasons. About 10 adults will receive pasireotide to see if it safely lowers prolactin levels …

This pilot study is testing whether giving two immunotherapy drugs, cemiplimab and fianlimab, before kidney cancer surgery is safe and practical. Ten people with locally advanced clear cell renal cell carcinoma will receive the drugs before their planned nephrectomy. The main goa…

This phase II trial tests whether a drug called BIO 300, made from a soy compound, can prevent severe lung inflammation (pneumonitis) in people with early-stage non-small cell lung cancer who also have interstitial lung disease. About 25 participants will receive BIO 300 along wi…

This study tests whether giving lower doses of radiation to certain head and neck cancer patients can still effectively treat the cancer while causing fewer side effects. Participants receive chemotherapy and radiation, and doctors use a special PET scan to decide who can get the…

This study tests whether giving a very focused, high-dose radiation treatment (SBRT) to all visible cancer spots can delay the cancer from getting worse in people with breast or lung cancer that has spread to 1-5 places. About 145 participants will either receive standard care al…

This study is for people with advanced breast cancer that is androgen receptor-positive (AR+) and either triple-negative or low in estrogen receptors. It tests whether the drug enzalutamide, alone or combined with mifepristone, can control the cancer as well as standard chemother…

This study is testing whether the drug trastuzumab deruxtecan can shrink tumors in people with a specific type of lung cancer (HER2-amplified or HER2-mutated) before they have surgery. About 14 participants with stage II to IIIB non-small cell lung cancer will receive the drug an…

This phase 2 trial tests whether two drugs, azacitidine and venetoclax, can eliminate or reduce measurable residual disease (MRD) in adults with acute myeloid leukemia (AML) who have completed standard chemotherapy and are scheduled for a donor stem cell transplant. The goal is t…

This study tests whether combining two drugs, axitinib and nivolumab, can shrink or control advanced mucosal melanoma that hasn't been treated before. About 20 adults with this rare cancer will receive the combination. The goal is to see if the drugs work better together than alo…

This study compares standard radiation (24 Gy) to a much lower dose (4 Gy) for people with follicular or marginal zone lymphoma. The goal is to see if the lower dose works just as well but causes fewer side effects. About 375 participants will be enrolled, and the study is curren…

This study tests whether a single, high-dose session of MRI-guided radiation can control colorectal cancer that has spread to the liver. Researchers will treat up to 32 adults with up to 3 small liver tumors. They will track tumor growth, side effects, and look for MRI features t…

This study tests whether combining two drugs, sacituzumab govitecan and cetuximab, can shrink or control advanced head and neck cancer that has grown after initial therapy. About 40 adults whose cancer has spread or returned will receive the combination. The goal is to see how ma…

This early-stage study tests a drug called codrituzumab in children and young adults (ages 1 to 21) whose solid tumors have come back or not responded to treatment and carry a specific protein called GPC3. The main goal is to find a safe dose and see how the body handles the drug…

This study tests whether adding the immunotherapy drug pembrolizumab, with or without the targeted drug olaparib, to standard radiation therapy is safe and effective for people with metastatic triple-negative or hormone-receptor-positive/HER2-negative breast cancer. About 34 adul…

This early-phase study tests a radioactive drug (131-I apamistamab) given before CAR T-cell therapy for people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia or diffuse large B-cell lymphoma. The goal is to find a safe dose and see if the combination is tolera…

This early-phase trial is testing a new type of immunotherapy called CAR T-cells for people with a specific kind of stomach and esophageal cancer that has spread to the lining of the abdomen. The treatment involves collecting a patient's own immune cells, modifying them in a lab …

This study is for people with advanced breast cancer (T3 or T4) who have responded well to chemotherapy. Usually, radiation is given after mastectomy, which delays reconstruction. Here, radiation is given before surgery, so reconstruction can happen immediately using the patient'…

This study tests whether switching between two different drug combinations (Dara-RVd and Tec-RVd) is safe and effective for people newly diagnosed with multiple myeloma. About 65 participants will receive alternating cycles of these therapies. The goal is to achieve undetectable …

This early-stage study is testing whether combining two drugs—teclistamab and mezigdomide—is safe and effective for people with multiple myeloma that has come back or stopped responding to other treatments. About 18 participants will receive the drugs in a specific sequence. The …

This phase 2 trial is testing whether a reduced chemotherapy regimen called N10 is safe and effective for children with high-risk neuroblastoma. The study will enroll 45 children under 19 years old who have not had more than one prior chemo cycle. The goal is to see if this light…

This early-phase trial tests a new type of CAR T-cell therapy for people with acute lymphoblastic leukemia (ALL) that has come back or not responded to standard treatments. The therapy uses a patient's own immune cells, which are modified in a lab to better recognize and attack l…

This study looks at whether people with plasma cell disorders can safely recover from an autologous stem cell transplant at home instead of in the hospital. Researchers want to see if home recovery is practical, reduces infections, and keeps patients satisfied. About 91 adults ag…

This study tests a drug called ASTX727 in people with a rare type of nerve tumor (MPNST) that has a specific genetic change (PRC2 loss). The drug combines two medicines to better attack cancer cells. About 25 adults and teens whose tumor has grown despite standard treatment will …

This study tests whether two drugs, botensilimab and balstilimab, can clear remaining cancer DNA in people with colorectal cancer who still have signs of disease after standard treatments like surgery and chemotherapy. About 284 adults with a specific type of colorectal cancer (M…

This study tests the safety of combining bexarotene (a vitamin A-like drug) with ultra-low dose total skin electron beam radiotherapy for people with mycosis fungoides, a common form of cutaneous T-cell lymphoma. About 20 adults with stage IB or higher disease will receive both t…

This study looks at two common choices during bladder cancer removal surgery: using a ureteral stent (a tube to drain urine) and giving the drug alvimopan to help the bowels work sooner. The goal is to see if these choices affect how long patients stay in the hospital and how man…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a combination of counseling, text messages, phone support, and self-monitoring tools. Researchers will enroll about 1,785 drivers in New York City to find out which parts of the program wo…

This study looks at whether a simple blood test (ctDNA) can help doctors decide if it's safe to stop maintenance immunotherapy after one year in people with advanced or recurrent endometrial cancer. About 30 participants will receive standard treatment, and if their ctDNA test is…

This study tests the drug cabozantinib in people with advanced non-small cell lung cancer whose tumors have certain gene changes (RET, ROS1, NTRK fusions or increased MET/AXL activity). The drug is taken by mouth and aims to shrink tumors and stop them from growing. About 86 part…

This study tests whether giving emapalumab early can help children with newly diagnosed severe aplastic anemia recover their blood cell counts within 6 weeks. About 35 children will receive the drug before standard treatments. The goal is to see if this approach improves treatmen…

This early-phase study tests a new treatment called MQ710, a modified virus injected directly into tumors, alone or with the immunotherapy drug pembrolizumab. It is for people with advanced solid tumors (like skin cancer or head and neck cancer) that have not responded to standar…

This early-stage trial tests whether SER-155, a mix of 16 live bacteria taken by mouth, can safely treat severe diarrhea and colon inflammation caused by cancer immunotherapy. The study will enroll 15 adults who have developed these side effects. The main goal is to check safety,…

This early-phase trial is testing whether adding abemaciclib to the standard drug ruxolitinib is safe and effective for people with myelofibrosis, a type of bone marrow cancer. The study will enroll 18 adults who have been on ruxolitinib for at least 12 weeks. Researchers will mo…

This study tests whether adding certolizumab (an anti-inflammatory drug) to standard chemotherapy and immunotherapy helps shrink stage II-III lung cancer more effectively before surgery. About 60 adults with operable lung cancer will receive the combination, then have their tumor…

This study tests a drug called tislelizumab for people in Nigeria with a specific type of colorectal cancer (mismatch repair deficient). The drug helps the immune system attack cancer cells. The study will check if the drug shrinks tumors and is safe. It includes 40 adults who ha…

This study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects com…

This study tests a standardized, optimized approach to cord blood transplantation for adults with high-risk blood cancers like leukemia and lymphoma. The method includes specific chemotherapy, radiation, and stem cell dosing, followed by careful monitoring. Researchers hope to im…

This study tests a new radioactive tracer called 89Zr-DFO-SC16.56 that attaches to a protein called DLL3 found on small cell lung cancer cells. The goal is to see if PET scans using this tracer can safely and accurately show where the cancer is in the body. About 53 adults with s…

This study is testing a new urine test that aims to detect colorectal cancer and precancerous polyps early. Researchers will enroll 210 people in Ghana, Tanzania, and South Africa who have symptoms like rectal bleeding or are getting a colonoscopy. The test uses a biosensor to fi…

This early-stage trial tests whether a special nanoparticle tracer can help surgeons see prostate cancer cells during surgery. Sixteen men with high-risk prostate cancer will receive an injection of the tracer, then undergo PET/MRI scans and surgery. The goal is to see if the tra…

This study tests a dedicated MRI scan of the pancreas (MRP) to see if it can detect pancreatic cancer earlier in people at high risk. About 79 participants with a strong family history or certain genetic mutations will get both the new MRI and an endoscopic ultrasound. The goal i…

This study tests whether using mobile health (mHealth) tools helps find early signs of oral cancer better than the usual visual exam in rural areas of Varanasi, India. Over 5,000 adults with risk factors like smoking, tobacco use, or age over 40 will be screened. The goal is to c…

This study compares a next-generation eye scanner (Intalight Dream OCT) with the current standard device (Heidelberg Spectralis OCT) to see which provides better images of eye tumors. Researchers will enroll 60 adults with ocular tumors and evaluate image quality and field of vie…

This study tests a new imaging agent called pHLIP ICG that makes breast cancer cells glow during surgery. The goal is to help surgeons see and remove all cancerous tissue more accurately. The trial involves 55 adults with early-stage breast cancer who have not had prior treatment…

This pilot study is testing whether a special PET/CT scan using 68Gallium PSMA can find cancer that has spread in people with metastatic bladder cancer or melanoma. Twenty participants will receive both the standard FDG-PET/CT scan and the new 68Ga PSMA-PET/CT scan within 10 days…

This study tests a new PET scan using a special form of iodine called iodine-124 to measure how much radioactive iodine thyroid cancer tumors absorb. The goal is to help doctors decide if standard radioactive iodine therapy is likely to help. About 60 adults with metastatic thyro…

This study tests a new technology called an electronic nose (E-Nose) that analyzes chemicals in a person's breath. Researchers want to see if it can accurately measure how well lung cancer responds to treatment and if the cancer comes back. The study involves 60 adults with non-s…

This study is testing a special camera that uses a laser to take microscopic pictures of suspicious spots inside the mouth. The goal is to see if these images can help doctors diagnose oral cancers and guide surgery. About 140 people with oral cancer will have their lesions image…

This study compares two types of PET scans to see which is better at finding and tracking metastatic lobular breast cancer. About 30 adults with this type of cancer will receive both an experimental FES PET/CT scan and a standard FDG PET/CT scan. The goal is to improve detection …

This study looks at whether people with unexplained weight loss who are at high risk for lung cancer are more likely to develop the disease. Researchers will use low-dose CT scans and blood tests to screen 409 participants over one year. The goal is to see if adding weight loss t…

This study is testing whether a new MRI technique using a substance called hyperpolarized pyruvate gives consistent results in people with solid tumors. About 109 participants will have two special MRI scans to see if the images are reproducible. The goal is to improve how doctor…

This study trains Nigerian radiologists to use tablet-based ultrasound to guide breast biopsies, a method that is more accurate than the blind biopsies or surgical excisions currently used. Nine hundred women with suspicious breast lumps will participate. The goal is to make this…

This study looks at whether combining special PET and MRI scans with blood tests can detect pancreatic cancer early in people who have pancreatic cysts. The goal is to avoid unnecessary surgery by identifying which cysts are truly dangerous. About 25 adults with high-risk cysts w…

This study is testing a new breath test, called an electronic nose (E-Nose), to see if it can measure how well treatment is working for people with malignant pleural mesothelioma (MPM). Researchers will collect breath samples from 20 patients before and during standard treatment,…

This study tests whether an educational video can increase women's interest in having their fallopian tubes removed during non-gynecologic surgery to prevent ovarian cancer. Participants watch a video and complete questionnaires before and after. The study involves 266 women aged…

This study tests a family-centered program to help Hispanic families lose weight and prevent obesity. About 1,319 parents and their children ages 8-12 will take part. The program uses text messages and family support to encourage healthy eating and activity.

This study tests whether a plant-based diet or supplements (omega-3 and curcumin) can change gut bacteria in people with MGUS or smoldering multiple myeloma, conditions that can lead to multiple myeloma. Researchers will measure butyrate levels in stool, a sign of healthy gut bac…

This study tests whether Stimulan Rapid Cure, a local antibiotic, can reduce infections in women receiving tissue expanders during mastectomy for breast cancer. About 392 participants will be randomly assigned to receive the antibiotic or standard care. The goal is to see if this…

This study tests whether starting sexual health counseling and using non-hormonal moisturizer right away can prevent vaginal dryness and sexual problems in premenopausal women with breast cancer who are on ovarian suppression. Fifty women will be randomly assigned to either this …

This study tests whether the drug mogamulizumab can prevent adult T-cell leukemia/lymphoma (ATL) in people infected with HTLV-1 who are at high risk. About 134 participants will receive low doses of the drug over several weeks. The goal is to see if it can reduce the virus levels…

This study tests whether a comprehensive program can prevent lymphedema (chronic arm swelling) in women undergoing lymph node removal for breast cancer. The program includes immediate lymphatic reconstruction during surgery, self-directed lymphatic massage, and regular arm measur…

This pilot study tests whether a combination of stress-reducing drugs (propranolol and etodolac) and mind-body techniques (resilience training and music therapy) can help women with advanced ovarian cancer feel less stress before, during, and after surgery. The study will enroll …

This study compares two exercise programs for women receiving chemotherapy for early-stage breast cancer. One program uses a fixed amount of walking each week, while the other adjusts the amount based on how each woman responds. The goal is to see which approach better improves c…

This study tests whether a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) can help reduce anxiety and depression in 300 Latino patients with advanced cancer. Participants receive either MCP-L or standard cognitive behavioral therapy over about 3 months. The goa…

This study is testing three different amounts of treadmill walking (90, 150, or 300 minutes per week) in people receiving chemotherapy for colorectal or stomach cancers. The goal is to find a safe and practical exercise level that helps patients complete their full chemotherapy p…

This study tests whether a type of talk therapy called behavioral activation (BA) can help treat depression in older adults who have survived cancer. Participants will receive BA or supportive psychotherapy remotely via video or phone over 10 weeks. The goal is to see if BA reduc…

This study tests a support program for Chinese cancer patients and survivors that includes education sessions, counseling, and peer support. The program is delivered by phone or video call. Researchers want to see if the program is practical and whether it improves quality of lif…

This study is for men with low- to intermediate-risk prostate cancer. It compares giving a lower radiation dose to some parts of the prostate versus the same dose to the whole prostate. The goal is to see if the lower dose reduces short-term urinary side effects. About 54 people …

This study tests a navigation program for cancer patients starting immunotherapy. The program helps with essential needs like food, transportation, and housing, and tracks side effects. Researchers want to see if this support helps patients continue their treatment and improves t…

This study tests a Hospital-at-Home program for people with small cell lung cancer receiving tarlatamab. The goal is to see if monitoring patients at home using telemedicine is as safe and effective as keeping them in the hospital after treatment. About 70 adults will take part, …

This study tests a program called ICCAN that gives cancer patients extra help with social and economic needs, like finding resources and monthly check-ins. Researchers want to see if this support helps patients complete their cancer treatment and improves their quality of life, c…

This study is testing a mobile app called TEAMWork that gives breast cancer patients advice on talking to their employers and doctors about work. The goal is to help patients keep their jobs during and after treatment. About 546 adults with breast cancer who are about to start or…

This study tests whether a single 60-minute counseling session can reduce anxiety and depression in breast cancer patients who are waiting for ongoing therapy. About 26 participants will receive the session plus a booklet, and researchers will measure how helpful and practical it…

This pilot study tests whether a buried free fat flap surgery can safely reduce neck problems like pain, stiffness, and swallowing trouble in people treated for head and neck cancer. Twelve adults who need a salvage neck dissection will receive the fat flap procedure. Researchers…

This pilot study is testing whether music therapy delivered over video calls is a practical way to help blood cancer survivors who have trouble with memory, attention, and thinking. Researchers will enroll 60 adults who have had lymphoma, leukemia, or myeloma. Participants will e…

This study looks at whether adding local anesthesia (numbing medicine) during a prostate biopsy, while patients are already sedated, reduces pain after the procedure. About 800 men will take part. The goal is to see if this simple change can lower pain scores, cut down on painkil…

This phase 2 trial tests whether real acupuncture can improve outcomes for hospitalized sepsis patients compared to a sham (fake) version. Researchers will enroll 78 adults at Memorial Sloan Kettering Cancer Center to see if such a study is feasible. The goal is to gather initial…

This phase 2 trial tests whether photobiomodulation (PBM) — a type of light therapy — can safely treat oral chronic graft-versus-host disease (GVHD), a painful mouth condition that can occur after a stem cell transplant. About 44 participants who have not responded to at least on…

This study compares music therapy and cognitive behavioral therapy (CBT) for reducing anxiety in people who have had cancer. 368 cancer survivors with anxiety will receive seven weekly virtual sessions of either music therapy or CBT. Researchers will track anxiety levels over 26 …

This study tests whether a traditional herbal formula called MZRW can help cancer survivors who suffer from constipation. Researchers will give 70 participants either MZRW or a placebo for two weeks and track bowel movements and gut bacteria changes. The goal is to see if MZRW is…

This study looks at whether giving sarcoma patients early access to mental healthcare before and after surgery can help with depression, anxiety, and quality of life. About 60 adults with bone or soft tissue sarcoma who are scheduled for surgery at Memorial Sloan Kettering will t…

This study tests whether eating a high-fiber plant-based diet (fruits, vegetables, nuts, beans, whole grains) can improve quality of life for people with clonal hematopoiesis (CH), a blood condition. Researchers will track changes through questionnaires. The study involves 36 adu…

This study tests a new phone-based therapy called CARE (Cancer and Aging: Reflections for Elders) to help older adults with cancer who feel depressed or distressed. About 459 participants aged 70 and older will receive either CARE or standard supportive counseling over the phone.…

This study compares two group therapy programs—Mindfulness Oriented Recovery Enhancement (MORE) and Supportive Psychotherapy—to help breast cancer survivors manage joint pain caused by aromatase inhibitors. About 200 women will attend weekly two-hour sessions for eight weeks and …

This study is testing whether a drug called pembrolizumab, given after a special type of radiation, is safe for people with advanced adrenocortical carcinoma that has spread to the liver. The trial will enroll 12 participants and focus on side effects. If successful, it may offer…

This study looks at whether acupuncture can help young women (ages 15-40) with cancer get their periods back after chemotherapy caused them to stop. About 60 participants will receive acupuncture or usual care. Researchers will measure how many people join and finish the study, a…

This study tests whether weight loss drugs like tirzepatide and semaglutide are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are undergoing chemotherapy. About 36 participants will take weekly doses for 24 weeks. Researchers w…

This study compares two methods to help men regain erectile function after prostate cancer surgery. About 224 men who had surgery within the past 9 months will take part. The goal is to see which approach works better for sexual rehabilitation.

This phase 3 trial tests whether a single dose of methylprednisolone given before major liver surgery can lower the risk of complications like infections and shorten hospital stays. About 750 adults scheduled for major hepatectomy will be randomly assigned to receive either the s…

This study compares a new radiation technique called lattice radiation therapy (LRT) to standard stereotactic body radiation therapy (SBRT) for people with solid tumors that have spread to soft tissues. The goal is to see if LRT shrinks tumors better and helps the immune system f…

This study looks at how different amounts of aerobic exercise (like walking or cycling) over different time periods affect heart and lung fitness in post-menopausal women who had early-stage breast cancer. About 152 women will take part. The goal is to find the best exercise plan…

This study is testing whether special herbal plasters placed on the skin can help manage pain in cancer patients and survivors who are already taking opioids. The goal is to see if adding these plasters to standard pain treatment is practical and effective. About 150 adults with …

This study tests a 7-session anxiety treatment program called MAC for Latino older adults with cancer and their caregivers. The therapy is delivered by phone or video by trained social workers. Researchers want to see if the program is practical and helpful for this group.

This study tests whether Revaree Plus, a hyaluronic acid vaginal suppository, can improve vaginal dryness in women with hormone-receptor-positive breast cancer. About 60 participants will use the suppository for 8 weeks. Researchers will measure changes in vaginal health using a …

This study tests a special mental health program called DESCANSO/REST for Spanish-speaking Latino cancer patients who feel depressed, tired, or have trouble sleeping. The program is delivered through telehealth (video or phone calls). Researchers want to see if it is practical an…

This early-stage trial tests whether a precise, one-time radiation treatment called stereotactic radiosurgery (SRS) can safely relieve chronic pain in the chest or abdominal wall. The pain must be linked to specific spinal nerves and not helped by standard pain medicines. Researc…

This study tests whether giving a fluorescent dye called fluorescein sodium before vulvectomy helps surgeons see and remove all extramammary Paget's disease cells. About 27 adults with noninvasive or microinvasive disease will receive the dye intravenously in the operating room. …

This study looks at whether the drug gabapentin should be routinely used for pain control in women having a mastectomy (breast removal surgery). About 1,896 patients will be randomly assigned to either have gabapentin removed from their pre-surgery medication list or continue as …

This study adapts a program called CONVO for Spanish-speaking Latinx adults with solid tumors. In the program, nurses talk with patients about their personal values during routine cancer care. The goal is to make care more respectful and supportive. About 234 adults will take par…

This study is testing whether a 12-week virtual program of mind-body classes (like yoga, dance therapy, and tai chi) can reduce fatigue and improve quality of life for people with head and neck, thoracic, gynecologic, or other cancers. About 480 adults currently receiving cancer …

This study adapts a counseling program called Meaning Centered Psychotherapy to better support Latinos with advanced cancer. The goal is to improve quality of life and spiritual well-being by addressing the unique challenges this community faces. Researchers will test the program…

This study looks at whether acupuncture is a practical option for cancer survivors who have ongoing joint pain. Researchers will enroll 60 racially diverse, underserved survivors and offer 10 weekly acupuncture sessions. The main goal is to see if people are willing to join and s…

This study adapts a counseling program called Meaning Centered Psychotherapy for Latinos with advanced cancer. The goal is to improve spiritual well-being and quality of life. Researchers will enroll 190 Latino adults with stage III or IV solid tumors to test the program's feasib…

This study looks at tongue strength and endurance in people who have had part of their tongue removed due to oral tongue cancer. Researchers will use a device called the Iowa Oral Performance Instrument (IOPI) to measure tongue pressure. Some participants will also use the IOPI a…

This study tracks how much radiation doctors are exposed to while performing robotic-assisted lung biopsies. About 350 procedures will be monitored across multiple hospitals using special badges. The goal is to understand current exposure levels and help make the procedure safer …

This study creates a registry of medical records, scans, and surveys from adults with neurofibromatosis type 1 (NF1) who also have a glioma brain tumor. Researchers will track diagnosis, treatments, and quality of life over time to better understand the disease. The goal is to im…

This study investigates the challenges and supports available for breast cancer diagnosis in Tanzania. Researchers will interview breast cancer survivors, patient advocates, and healthcare personnel to identify barriers to hormone receptor testing. The goal is to gather informati…

This study tests whether a decision aid tool called RECONJOINT is practical for helping women choose breast reconstruction after mastectomy. About 131 women with breast cancer or a genetic risk will use the tool. The goal is to see if a larger study can be done to improve shared …

This study aims to safely collect health information like heart rate and activity levels from cancer patients using devices like smartphones and wearables. Researchers will use this data to learn more about how it relates to cancer diagnosis, treatment response, and risk factors.…

This study is looking at how radiation therapy for head and neck cancer might affect thinking skills like memory and attention. Researchers will ask 60 newly diagnosed patients to complete thinking tests and questionnaires three times over one year. The goal is to learn more abou…

This study is a registry that will follow 600 people with early-stage lung cancer who undergo a surgery called segmentectomy. Participants will fill out questionnaires about their health before surgery, shortly after, and six months later. The goal is to measure how long people l…

This study aims to learn more about how the body responds to standard treatments for rectal cancer, including chemoradiation and chemotherapy. Researchers will analyze participants' blood, tissue, and scans to see if these tests can predict whether the cancer improves, worsens, o…

This study looks at how breast cancer cells change after a short course of hormone therapy in women with and without a BRCA2 gene mutation. Researchers will measure a protein called Ki67, which indicates how fast cancer cells are growing. The goal is to see if BRCA2 carriers have…

This study compares brain development in children who had multiple anesthesia exposures during retinoblastoma treatment to children who never had anesthesia. Researchers will use intelligence and memory tests to see if there are differences. The goal is to understand if anesthesi…

This study takes a small skin sample from breast cancer patients who have received certain chemotherapies. Researchers will turn those skin cells into heart cells in a lab to study why some patients develop heart problems. The goal is to learn more about the link between treatmen…

This study looks at how the drug enfortumab vedotin affects nerves in people with advanced or muscle-invasive bladder cancer. Researchers will use nerve tests and patient surveys to track changes over 9-15 weeks. The goal is to better understand and potentially reduce nerve damag…

This study is testing whether daily voice recordings can help doctors spot early signs of a brain-related side effect called ICANS in people receiving CAR T-cell therapy for non-Hodgkin lymphoma or multiple myeloma. About 20 participants will use their smartphones to record their…

This study is testing a new questionnaire called PRO-AYA, designed to measure quality of life in adolescents and young adults (ages 15-39) with cancer. Researchers want to see if the survey is reliable and accurate, including a Spanish version. 120 participants will fill out the …

This study is creating a database to track how people with esophageal or gastroesophageal junction cancer that has spread to only a few places (like the liver or lymph nodes) are treated in real-world settings. Researchers will collect information from 50 participants to see whic…

This study looks at how women with BRCA1 or BRCA2 gene mutations respond to learning about additional genetic risk factors. Researchers will follow about 800 women who have not had breast cancer, asking them to complete questionnaires and provide saliva or cheek swab samples. The…

This study is creating a large database of information and tissue samples from 1,000 people with T-cell lymphoma. Researchers will use this data to learn more about the disease and how to improve patient outcomes. Participants provide medical information and optional blood and na…

This study follows 100 people with desmoid-type fibromatosis, a rare tumor, for 12 months without giving any treatment. The goal is to see how often the tumors stay stable or shrink on their own. Participants get regular MRI or CT scans to track changes. The results could help do…

This study looks at how memory, attention, and thinking skills change over time in women aged 60-80 who are long-term breast cancer survivors. Researchers will compare them to healthy volunteers of the same age using computer tests. The goal is to understand if past cancer treatm…

This study compares three types of remote medical interpreting for Spanish- and Mandarin-speaking breast cancer patients with limited English proficiency. Researchers will measure how many interpretation errors occur during doctor visits. The goal is to find which method works be…

This study follows 1,250 women who have had lymph node removal during breast cancer surgery. Researchers use arm measurements and tissue tests to see who develops lymphedema (arm swelling) and why. The goal is to find early warning signs and improve quality of life.

This study tests a new 3D technology that combines standard scans (like CT or MRI) with real-time images to help surgeons guide head and neck surgery more precisely. About 27 adults scheduled for head and neck surgery will have a 3D scan created using a smartphone app during a st…

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study is gathering information from 100 adults with a type of thyroid cancer that no longer responds to standard radioactive iodine treatment. Doctors are using special medications called redifferentiating agents to try to make the cancer respond again. The goal is to track …

This study looks at whether exercise after finishing cancer treatment is linked to better outcomes, like longer survival without the cancer coming back. Researchers will analyze data from 1,000 adult cancer survivors at Memorial Sloan Kettering. The goal is to see if those who ex…

This study looks at whether a special MRI scan (cardiac MRI) can help doctors understand blood clots that form in the heart's right chamber from central lines (thin tubes used for treatment). Researchers will study 150 adult cancer patients to see if the MRI can tell how old the …

This study is testing whether noninvasive imaging methods can help doctors diagnose skin and mouth lesions more accurately before deciding on a biopsy. Researchers will collect images from up to 5,010 participants, including healthy volunteers and patients with lesions, using a s…

This study looks at how people with BRCA1/2 gene mutations react to additional genetic risk testing for prostate cancer. Researchers want to understand how this information affects their decisions about cancer screening. The study involves 150 men aged 45-70 who carry a BRCA1/2 m…

This study collects health information from 500 adults with painful bone metastases that have spread from other cancers. Researchers aim to better understand the disease and track survival over time. No new treatments are given; participants simply share their medical data.

This study follows 300 people who had surgery to remove bone tumors (like osteosarcoma or chondrosarcoma). Researchers want to see how well the bone heals and how much function returns over 3 years. Participants fill out questionnaires about their daily activities. No new drug or…

This study is for women 18 and older who have a suspicious breast finding or a new breast cancer diagnosis. Researchers will collect tissue and blood samples and ask participants to fill out questionnaires during their regular care. The goal is to learn more about what affects br…

This study is testing new MRI techniques to get more detailed images of head and neck and thyroid cancers. About 200 adults will have extra MRI scans before, during, or after treatment. The goal is to see if these scans can provide early clues about how well a treatment is workin…

This study is testing whether two types of PET scans can better detect where prostate cancer has spread in the body. About 300 men with prostate cancer that is getting worse will receive injections of a radioactive tracer and then be scanned. The goal is to see if these scans are…

This study is creating a registry of DNA and health information from 750 people with kidney cancer, their family members, and healthy volunteers. Researchers will use this data to better understand the genetics of kidney cancer, with the goal of improving prevention, diagnosis, a…

This study observes older patients (60+) receiving standard CAR-T therapy for blood cancers. Researchers track how treatment affects daily activities, thinking skills, and overall quality of life. No extra treatments are given—just careful monitoring to learn more about patient e…

This study looks at how chemotherapy and radiation affect the reproductive and sexual health of young adults with early onset colorectal cancer. Researchers will track hormone levels and fertility over time in 120 men and women. The goal is to better understand the long-term effe…

This study is observing about 1,715 people with early-stage endometrial cancer to see how often the cancer comes back and how often lymphedema (swelling) happens after standard treatment. Participants will have regular check-ups for 36 months. The goal is to gather real-world dat…

This study looks at whether a new telehealth program can help people with breast or prostate cancer get care from home instead of traveling to the doctor's office. About 1,750 patients at Memorial Sloan Kettering will take part. The goal is to see if this approach reduces the num…

This study tests whether a special training program can help cancer doctors communicate more empathetically with lung cancer patients. Many lung cancer patients feel judged or stigmatized during medical visits, which can harm their well-being and care. The training teaches doctor…

This study is testing whether taking a needle biopsy right after a tumor ablation procedure for liver metastases can detect cancer cells that survived the treatment. The results could help doctors decide if more treatment is needed right away. The study also looks at imaging and …

This study looks at how Y90 radioembolization, a radiation treatment for liver tumors that have spread from colorectal cancer, actually works inside the body. Researchers will collect small tissue samples (biopsies) from the liver after treatment to see how much tumor damage occu…

This study aims to find out which small thyroid cancers (papillary microcarcinoma) are likely to grow and cause problems. Researchers will analyze genetic and clinical features from 750 adults with these small tumors who are being monitored without immediate treatment. The goal i…

This study reviews the medical records of about 4000 people who had surgery for esophageal cancer. The goal is to see how the amount of cancer left at the edges of the removed tissue affects how long people live. No new treatments are given; the study only looks at past informati…

This study aims to develop and test a new MRI technique to distinguish between actual tumor growth and changes caused by radiation treatment in people with brain metastases. Researchers will include both healthy volunteers and patients who have had stereotactic radiosurgery. The …

This study follows 475 women with breast cancer or lymphoma to understand how their treatments affect sexual function and fertility. Participants complete questionnaires and may optionally provide blood samples to measure ovarian health. The goal is to learn about these long-term…

This study at Memorial Sloan Kettering Cancer Center is testing new ways to use MRI and CT scans to improve radiation therapy planning and tumor response checks. About 837 adults, including healthy volunteers and cancer patients, will undergo extra scans over time. The goal is to…

This study looks at how much of the drug T-DXd enters brain tumors in people with HER2-positive brain cancers or glioblastoma. Thirty participants will receive T-DXd before surgery to remove a brain tumor, and researchers will measure drug levels in the tumor. The goal is to see …

This study looks at tiny particles called exosomes, which carry proteins and genetic material between cells. Researchers will collect blood and tissue from 181 people with pancreatic cancer or noncancerous pancreatic disease to compare exosome activity. The goal is to understand …

This study looks at the genes in cancer tumors to find mutations that might be important for how the cancer grows. Researchers will use leftover tissue from surgeries or biopsies, along with a blood or saliva sample, to compare cancer genes to normal genes. The goal is to underst…

This early-phase study is testing a new imaging agent called [68Ga]-pentixafor to see how well it shows up on PET/CT scans in people with certain blood cancers (like multiple myeloma and non-Hodgkin lymphoma) and rare immune cell tumors. About 30 participants will get the agent a…

This study creates a database of information from people diagnosed with colorectal cancer before age 50. Researchers will compare this to data from older patients to find differences and potential causes. Participants complete a risk factor questionnaire and provide medical infor…

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect blood, tissue, and survey data from 800 adults in South Florida, including those with suspicious breast findings or newly diagnosed breast cancer. By analyzing …

This study creates a registry of DNA and health information from 1,000 people with germ cell or testicular tumors, plus their relatives and unrelated volunteers. Researchers will collect data on diagnosis, family history, and risk factors to learn why some people develop these tu…

This study is observing 250 adults undergoing surgery to understand how heart function and blood flow change when general anesthesia is given. Researchers focus on those who develop low blood pressure after anesthesia induction. Using echocardiography and blood pressure measureme…

This study is building a registry of 3,200 people with early changes in the stomach lining that can lead to gastric cancer. Researchers will collect information on lifestyle, diet, and other risk factors through questionnaires. The goal is to better understand why some people dev…

This study aims to find the genetic causes of certain blood cancers like lymphoma, leukemia, and multiple myeloma by studying families where more than one person has the disease. Researchers will collect DNA and blood samples from up to 500 participants, including patients and th…

This study tracks over 1,300 people with blood cancers like acute leukemia to see how many receive a stem cell transplant. Researchers want to understand the medical and personal reasons why some patients get this treatment while others do not. The goal is to identify barriers so…

This study is a patient registry for people diagnosed with desmoplastic small round cell tumor (DSRCT), a rare cancer. Researchers will collect health information from up to 250 participants of any age to build a database for current and future studies. The goal is to better unde…

This study creates a registry for people with Erdheim-Chester disease and related histiocytoses. Researchers will collect medical information and patient experiences over time to better understand these rare conditions. Up to 500 participants will be enrolled, and some may be ask…

This study tests whether a special ultrasound can measure changes in vaginal tissue caused by radiation therapy for endometrial cancer. Ten participants will have ultrasound scans before and after treatment to see if the method works. The goal is to better understand and monitor …

This study is testing a new spinal fluid test that looks for tumor DNA in people with aggressive B-cell lymphoma who are at high risk for the cancer spreading to the brain. Researchers want to see how often this test finds signs of lymphoma that standard tests miss. About 50 part…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…

This study aims to discover new genes that increase the risk of developing cancer, especially in people with a strong family history or unusual cancer patterns. Researchers will analyze genetic data from 1,500 adults and children who have or may develop inherited cancer. The goal…

This study is testing whether a special type of ultrasound called multiparametric ultrasound (mpUS) can provide more detailed images of tissue than standard ultrasound. Researchers will compare mpUS results with regular tests in up to 85 people who are at high risk for pancreatic…

This study aims to create a simple, minimally invasive test to find pancreatic cancer at an early stage and track how well treatment is working. Researchers will study 700 people with pancreatic cancer, pancreatitis, or pancreatic cysts. The goal is to identify biological markers…

This study looks at two new approaches to cancer genetic counseling. The first helps doctors reach out to family members who may have inherited a cancer-related gene change, making it easier for them to get tested. The second uses an online portal to keep patients and their docto…

This study looks at how a short-term plant-based diet or supplements (omega-3, curcumin, or probiotics) change levels of butyrate—a healthy gut compound—in people with smoldering multiple myeloma or MGUS. About 200 participants will be randomly assigned to one of the diet or supp…

This study follows 120 adults with lymphoma who are receiving CAR-T cell therapy. Researchers will test memory, attention, and other thinking skills, and perform brain MRIs and blood tests before and after treatment. The goal is to understand how CAR-T therapy may affect the brai…

This pilot study at Memorial Sloan Kettering tests whether giving cancer patients an indoor air quality monitor helps them maintain a smoke-free home. Ten participants who smoke and are in a tobacco treatment program will use the monitor for about 60 days. Researchers will see if…

This study is not testing a new treatment. Instead, it follows 300 people aged 14 and older with Cushing's syndrome to collect data on their health before and after standard treatments like surgery, medication, or radiation. The goal is to build a registry that helps doctors unde…

This study aims to create and improve educational materials about genetic testing for cancer patients from diverse backgrounds. Researchers will interview 445 people with breast, ovarian, pancreatic, prostate, or colorectal cancer who speak English, Spanish, or Haitian Creole. Th…

This study tests a program that screens cancer patients for emotional distress and refers them to mental health services if needed. It involves 50 English- or Spanish-speaking adults with new solid tumor cancers at Jamaica Hospital Medical Center. The goal is to see if such a pro…

This study aims to understand the genetic and biochemical makeup of neuroblastic tumors in children. By analyzing tumor samples and blood, researchers hope to learn how these tumors grow and spread. The information gathered will help doctors choose the most effective treatments f…

This study looks at how BRCA gene mutations and breast cancer treatments affect the ovaries in premenopausal women. Researchers will measure hormone levels in the blood before, during, and after cancer therapy to understand the risk of early menopause and fertility problems. Abou…

This study uses advanced MRI scans to better identify parts of brain tumors that are likely to grow back after standard treatment. Researchers will compare these scans with usual methods to see if they can improve radiation planning. About 135 adults with certain brain tumors wil…

This study collects blood, tissue, and stool samples from 160 people aged 18-49, including those with young onset colorectal cancer and healthy volunteers. Researchers will analyze the samples to create a database that helps explain why colorectal cancer is rising in younger adul…

This study is testing a new communication training program called Hematolo-GIST for doctors who treat large B-cell lymphoma. The goal is to help doctors better discuss the diagnosis and plan future care with their patients. About 48 people (doctors and patients) will take part to…

This study is a registry that gathers medical information from up to 100 people who have either large dark skin patches present at birth or a rare brain condition called neurocutaneous melanocytosis. The goal is to collect data on how these conditions are treated and how they pro…

This study follows 600 people with lymphedema to compare quality of life between those who choose surgery (a lymph node transfer) and those who choose non-surgical management. Participants fill out questionnaires about their symptoms and daily life over time. The goal is to under…

This study surveys 250 informal caregivers (family or friends) of people with Erdheim-Chester disease and similar conditions. Participants complete online questionnaires about their supportive care needs, mood, and sense of purpose. The goal is to identify what caregivers need mo…