Memorial Sloan Kettering Cancer Center

This study is testing a modified stem cell transplant procedure for children and adults with severe sickle cell disease or beta-thalassemia. The goal is to cure these genetic blood disorders by replacing a patient's faulty blood-making cells with healthy ones from a half-matched …

This study is testing whether a personalized treatment approach can lead to long-term remission or cure for people with advanced HER2-positive breast cancer. Researchers will use regular blood tests to guide treatment decisions, adjusting therapies based on cancer activity while …

This study is testing whether a blood test that detects cancer DNA can help doctors and patients decide when to stop immunotherapy treatment for advanced endometrial cancer. After one year of standard chemotherapy and immunotherapy, participants with negative blood tests may choo…

This study is testing if a blood test that looks for tiny bits of cancer DNA can help doctors decide which patients need radiation after surgery for HPV-related throat cancer. The goal is to see if some patients can safely delay radiation or receive a shorter course of treatment.…

This study is testing the safety of using cord blood for transplants in children and young adults (up to age 21) with life-threatening blood cancers or genetic blood disorders who do not have a perfectly matched donor. The main goal is to measure how many patients survive the fir…

This study is testing whether giving hormone therapy before surgery helps women with a specific type of breast cancer have better surgical outcomes. Researchers want to see if this approach reduces the chance that cancer cells are left at the edges of removed tissue, which often …

This study is testing whether giving radiation therapy before mastectomy surgery allows for immediate breast reconstruction using the patient's own tissue. Currently, patients with advanced breast cancer typically wait months after surgery for reconstruction. Researchers want to …

This study is testing if adding the drug siltuximab to a personalized dose of chemotherapy (melphalan) works better than the standard chemotherapy dose for people over 60 with multiple myeloma who are getting a stem cell transplant. The goal is to see if this combination helps co…

This study is for people with a specific type of advanced lung cancer (EGFR-mutant). It tests if adding standard chemotherapy to the usual targeted drug (osimertinib) works better than the drug alone. The goal is to see if the combination can keep the cancer from growing or sprea…

This study is testing whether a combination of two oral drugs, avutometinib and defactinib, can help control advanced or recurrent mesonephric gynecologic cancer. It will enroll about 40 adult women whose cancer has persisted or returned after prior treatment. The main goal is to…

This study is testing whether a targeted drug called trastuzumab deruxtecan can shrink tumors in people with a specific type of lung cancer (HER2-positive) before they have surgery to remove them. The goal is to see if giving the drug first makes the surgery more effective by kil…

This study compares different FDA-approved treatments for bladder cancer that hasn't spread into the muscle wall. It tests a newer gene therapy drug called nadofaragene firadenovec against several standard treatment options. The trial is for adults whose cancer returned after ini…

This study is testing whether the drug pasireotide can help control prolactinoma tumors in people who cannot take or don't respond to standard dopamine agonist medications. Researchers will enroll about 10 adults who are not candidates for surgery to see if pasireotide safely low…

This study is testing a new combination of two existing drugs, lorlatinib and ramucirumab, for people with advanced lung cancer that has a specific genetic change called ALK. The main goals are to find the safest dose of the drug combination and to see how well it works at contro…

This study is testing whether combining three immunotherapy drugs—fianlimab, cemiplimab, and ipilimumab—is safe and effective for people with advanced melanoma that has continued to grow despite previous immunotherapy treatment. The trial will enroll 88 adults whose melanoma has …

This study is testing whether a newer combination of targeted drugs causes fewer serious side effects than the current standard chemotherapy treatment for hairy cell leukemia. Researchers will enroll 86 adults who haven't received any prior treatment for their cancer. They'll com…

This study is testing whether adding two targeted drugs (tucatinib and trastuzumab) to standard chemotherapy before surgery can help shrink tumors in people with a specific type of rectal cancer (HER2-positive). The main goal is to see if this combination leads to a complete disa…

This study is testing the safety of a new two-drug combination (avutometinib and defactinib) for children and young adults (ages 3-30) whose solid tumors have come back or stopped responding to standard treatments. The main goal is to find the highest dose that is safe and causes…

This early-stage study is testing the safety of a drug called deferoxamine when it is injected directly into the spinal fluid. The goal is to treat cancer that has spread to the lining of the brain and spinal cord (leptomeningeal metastases) from solid tumors like lung or breast …

This early-stage trial is testing a new drug called CRD3874-SI in people with advanced cancers that have spread or returned after previous treatments. Researchers will first find the highest safe dose, then test that dose in patients with specific cancers like sarcoma and Merkel …

This study is testing whether people with a specific type of lung cancer can be safely monitored at home after receiving a new drug treatment, instead of staying in the hospital. Researchers want to see if a 'Hospital-at-Home' program using telehealth is a more efficient way to w…

This study is testing whether a much lower dose of radiation, combined with standard chemotherapy, can effectively control HPV-positive throat cancer while causing fewer side effects. It will involve 121 adults with this specific cancer type who have not had prior radiation to th…

This study is testing whether a precise, high-dose radiation treatment called stereotactic radiosurgery (SRS) can help people with small cell lung cancer that has spread to the brain. It will measure how many participants are still alive 6 months after receiving the treatment. Th…

This study is testing whether adding an experimental immunotherapy drug called retifanlimab to standard chemotherapy (gemcitabine and docetaxel) is safe and more effective for treating advanced soft tissue sarcoma. The goal is to see if the combination can better control the canc…

This study is testing whether a drug called mosunetuzumab, given alone or with another drug called zanubrutinib, is an effective first treatment for people with follicular lymphoma, a type of blood cancer. It will involve about 152 adults who have been recently diagnosed and have…

This study is testing whether adding four targeted drugs (gefitinib, trametinib, disulfiram, and sunitinib) to standard chemotherapy works better than standard chemo alone for people with metastatic osteosarcoma, a serious bone cancer. It will enroll about 45 participants, includ…

This early-stage study is testing whether a radioactive drug called Lutetium-177-PSMA-617 is safe for people with aggressive types of brain cancer called gliomas. The treatment uses a molecule that seeks out and delivers radiation directly to tumor cells that have a specific mark…

This study is testing whether adding newer drugs (glofitamab, polatuzumab, and obinutuzumab) to standard lymphoma treatment works better for older adults with aggressive B-cell lymphoma. Researchers want to see if this combination can effectively control the cancer while causing …

This early-stage study is testing whether a combination of two drugs, valemetostat and atezolizumab, is safe and effective as a maintenance therapy for people with extensive-stage small cell lung cancer. The goal is to help keep the cancer from growing or returning after patients…

This study is testing whether combining a targeted, high-dose radiation treatment with an immunotherapy drug called pembrolizumab is safe for people with advanced adrenal cancer that has spread to the liver. The main goal is to see if this two-part treatment causes few or managea…

This study is testing whether following a specific diet can improve how well standard chemotherapy works and boost quality of life for people newly diagnosed with multiple myeloma, a type of blood cancer. Researchers will randomly assign 220 participants to either follow a prescr…

This study is testing whether adding an immunotherapy drug called TSR-042 before standard chemoradiation and surgery works better for advanced solid tumors with specific genetic features. Researchers want to see if this combination helps eliminate cancer cells more effectively. T…

This study is testing a procedure called gastric preconditioning to see if it can reduce dangerous leaks after surgery to remove esophageal cancer. It is for patients who are at high risk for these leaks due to their health history or the type of surgery needed. The procedure inv…

This study is testing whether a new combination of three drugs is safe and effective for people with an aggressive type of lymphoma that has come back or stopped responding to previous treatments. Researchers are enrolling adults whose cancer has returned after at least two prior…

This small pilot study is testing whether giving cancer patients an indoor air quality monitor helps them keep their homes smoke-free. Researchers want to see if using the monitor for two weeks is practical and if patients attend related workshops. The goal is to improve air qual…

This study is testing if a wearable device that delivers low-intensity electrical fields (TTFields) to the chest is safe and practical to use before surgery for early-stage lung cancer. Researchers want to see if this treatment can help activate the body's own immune system to at…

This study is testing whether adding daratumumab to a standard three-drug combination (CyBorD) is safe and effective for treating kidney damage caused by monoclonal gammopathy of renal significance (MGRS). The trial will enroll 20 adults with MGRS-related kidney disease who have …

This study is testing whether the drug sotorasib is safe and effective as the first treatment for people with advanced non-small cell lung cancer that has a specific KRAS G12C mutation. The trial will enroll 39 adults who haven't received any treatment since their cancer became a…

This study is testing an oral drug called cabozantinib in people with advanced non-small cell lung cancer that has specific genetic changes (like RET, ROS1, or NTRK fusions). The main goal is to see if the drug can shrink the cancer and stop it from growing. Researchers will also…

This study is testing whether combining three existing drugs—pembrolizumab, olaparib, and temozolomide—is safe and effective for people whose glioma brain tumor has returned or stopped responding to prior treatment. It aims to see if this combination can better control tumor grow…

This early-stage study is testing whether combining two drugs, epcoritamab and ibrutinib, is safe for people with lymphoma that has returned in or spread to the brain after prior treatment. The main goal is to find a dose that causes few or manageable side effects. It will includ…

This early-stage study aims to find out if it's safe to combine two treatments for a type of skin lymphoma called mycosis fungoides. Researchers will give participants the drug bexarotene along with a special, low-dose radiation treatment that covers the entire skin surface. They…

This study is testing whether combining two drugs, mirdametinib and palbociclib, is safe and effective for people with advanced liposarcoma that has spread, returned, or cannot be surgically removed. Researchers will first find the safest dose of mirdametinib to give with a fixed…

This early-stage study is testing a personalized treatment called lifileucel for patients with advanced uveal melanoma (a rare eye cancer) or certain aggressive soft-tissue sarcomas. Doctors take a patient's own immune cells from their tumor, grow large numbers of them in a lab, …

This early-phase study is testing the safety of a new type of CAR T-cell therapy for adults and teenagers (12+) with acute lymphoblastic leukemia (ALL) that has come back or not responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to bett…

This study is testing whether a new combination treatment is safe for men with prostate cancer that has spread to a few other areas in the body. The treatment combines a targeted radioactive drug (177Lu-PSMA617) that seeks out cancer cells, followed by precise, high-dose radiatio…

This study is testing if using highly focused radiation on a single tumor that has started growing again can help people with metastatic breast cancer stay on their current effective drug treatments longer. Participants will receive this targeted radiation while continuing their …

This study is testing whether a combination of a vaccine, an oral sugar supplement (beta-glucan), and an immune-stimulating protein (GM-CSF) can help prevent cancer from coming back in people with high-risk neuroblastoma who are currently in remission. The treatment aims to train…

This study is testing whether a combination of three medications—avutometinib, defactinib, and letrozole—can effectively treat low-grade serous ovarian cancer. It is for patients who are not candidates for complete initial surgery or who still have measurable disease after surger…

This study is testing whether patients with blood cancers can safely recover from stem cell transplants at home instead of in the hospital. Researchers want to see if home recovery reduces hospital readmissions and improves patient satisfaction while maintaining safety. The trial…

This study is testing whether the drug isatuximab can help adults who develop severe, treatment-resistant low blood counts after a stem cell transplant for blood cancer. The goal is to see if the drug can effectively restore healthy blood cell levels in these patients. It is for …

This study is testing a new, reduced chemotherapy plan called N10 for children with high-risk neuroblastoma, a serious childhood cancer. The goal is to see if this less intense treatment is still effective and safe for patients under 19 years old. Researchers want to find out if …

This study is for people with a specific type of breast cancer (HER2-positive) that has spread to only a few other places in the body. Researchers want to know if adding surgery or targeted radiation to the standard drug treatment helps keep the cancer under control for longer co…

This early-stage study is testing a new type of CAR T-cell therapy called ADCLEC.syn1 in adults whose acute myeloid leukemia has returned or hasn't responded to standard treatments. The main goal is to find the highest dose that is safe and causes only mild side effects. Once a s…

This study is testing whether the drug enasidenib is a safe and effective treatment for adults with a rare and aggressive type of blood cancer called angioimmunoblastic T-cell lymphoma (AITL) that has a specific genetic change (IDH2 mutation). Researchers will give enasidenib eit…

This study is testing whether a single, powerful session of MRI-guided radiation can stop liver tumors from growing in people whose colorectal cancer has spread there. Researchers will see if this one-time treatment is effective and safe, and if special MRI images can predict how…

This study is testing whether adding an experimental drug called BMS986365 to standard hormone therapy before prostate removal surgery is safe and effective for men with high-risk prostate cancer that hasn't spread. Researchers want to see if this combination can completely elimi…

This study is testing whether a fluorescent dye given by IV before surgery can help surgeons better see and remove all cancer cells during an operation for extramammary Paget's disease of the vulva. Researchers want to see if using the dye reduces the chance that cancer cells are…

This early-stage study is testing a new treatment for adults with acute myeloid leukemia (AML) that has returned or not responded to other therapies. Researchers are combining specially trained immune cells, called NK cells, from a family donor with a drug called atezolizumab. Th…

This study is testing whether adding the immunotherapy drug pembrolizumab to a standard chemotherapy regimen (called GVD) is safe and effective for adults with Hodgkin lymphoma that has returned or did not respond to first treatment. The goal is to control the cancer and see if t…

This study is testing whether combining the drugs axitinib and nivolumab is a safe and effective first treatment for adults with advanced mucosal melanoma, a rare and aggressive cancer. The researchers believe blocking two different cancer growth pathways at once may work better …

This early-stage study aims to find the safest and most effective dose of the drug abemaciclib when given at the same time as targeted radiation therapy. It is for people with advanced, hormone-sensitive breast cancer that has spread to the bones. The goal is to see if this combi…

This study is testing whether a three-drug combination followed by ongoing maintenance therapy can effectively treat and prevent relapse in older adults with a specific type of acute myeloid leukemia (AML). Researchers want to see if this approach keeps the cancer from returning …

This study is testing whether a different medication approach can better prevent chronic graft-versus-host disease (GVHD) after stem cell transplants for blood cancers. Researchers will compare a new strategy using the drug ruxolitinib against the standard prevention method. The …

This study is testing whether the immunotherapy drug tislelizumab is a safe and effective treatment for colorectal cancer patients in Nigeria who have not yet received any cancer treatment. The trial focuses on patients whose cancer has a specific genetic feature called mismatch …

This study aims to see if two different drug treatments can help people with rare, hard-to-treat immune disorders get ready for a stem cell transplant. Researchers want to know if the treatments can calm the body's harmful inflammation, making it easier for the new donor cells to…

This study is testing whether a drug called elacestrant works better alone or combined with abemaciclib for people with advanced or returning endometrial cancer that has estrogen receptors. The trial will enroll 75 participants who have already received platinum-based chemotherap…

This study is testing if adjusting the dose of a chemotherapy drug (fludarabine) based on a patient's individual metabolism improves the effectiveness of a subsequent CAR-T cell therapy for children and young adults with relapsed or hard-to-treat B-cell acute lymphoblastic leukem…

This study is testing a weight loss program designed for taxi and ride-share drivers in New York City. It will compare four different support methods—like personal counseling, text messages, and weekly calls—to see which combination works best to help drivers lose at least 5% of …

This early-stage study is testing whether combining two drugs, teclistamab and mezigdomide, is safe and effective for people with multiple myeloma that has come back or stopped responding to other treatments. The main goal is to find the safest dose and see if the combination can…

This study is testing whether a very low dose of radiation therapy works as well as the standard, higher dose for people with early-stage, slow-growing B-cell lymphomas. Researchers want to see if the lower dose can control the cancer just as effectively while causing fewer side …

This study is testing whether the drug combination ASTX727 can help control advanced malignant peripheral nerve sheath tumors (MPNST) that have a specific genetic change called PRC2 loss. The trial is for about 25 patients aged 16+ whose cancer has worsened after at least one sta…

This early study is testing whether weight loss medications tirzepatide and semaglutide are practical and safe for endometrial cancer patients who are overweight or have diabetes and are undergoing chemotherapy. Researchers will enroll 36 patients to see if they can complete the …

This study is testing whether a shorter, 5-day course of radiation is a safe and effective alternative to the standard longer treatment for women with early-stage breast cancer who have had a lumpectomy. It aims to see if this approach causes few or mild side effects while still …

This study is testing whether the drug enfortumab vedotin is safe and effective when given before surgery to people with aggressive cancer in their upper urinary tract (kidney or ureter). The trial is for patients who are not eligible for or have chosen not to receive the standar…

This study is testing a new software tool that analyzes DNA from a simple blood test. The goal is to see if this tool can accurately predict which cancer patients are at low risk for their blood clots returning. If successful, it could help doctors safely stop blood thinner medic…

This study is testing whether the drug talquetamab can help control multiple myeloma in patients who have already received a specific CAR-T cell therapy (ide-cel) but whose cancer has returned or resisted treatment. The goal is to see if giving talquetamab after the CAR-T therapy…

This study is testing whether a combination of two drugs, sacituzumab govitecan and cetuximab, can help control advanced head and neck cancer that has come back or spread after initial treatment. It will involve about 40 adults whose cancer has progressed despite standard therapy…

This study is testing whether a combination of two immunotherapy drugs can help prevent colorectal cancer from coming back in patients who have already had surgery and chemotherapy. The treatment is for people who still have tiny traces of cancer DNA in their blood after standard…

This study is testing a targeted radiation treatment for children and young adults whose neuroblastoma or related tumors have not responded to standard therapies. The treatment uses a radioactive drug that seeks out and delivers radiation directly to cancer cells. Researchers aim…

This study is testing if time-restricted eating (eating within a set daily window) combined with regular health coaching calls helps adult survivors of childhood cancer lose weight and improve their heart and metabolic health. It will compare this approach to just receiving educa…

This study is testing whether a combination of two immunotherapy drugs, enfortumab vedotin and pembrolizumab, can effectively treat people with advanced bladder cancer that has spread to nearby lymph nodes. The drugs are given before surgery to remove the bladder, with the goal o…

This study is testing whether the drug selinexor can help control certain childhood solid tumors that have come back or have not responded to standard treatments. It is for children as young as 1 year old who have specific cancers like Wilms tumor, rhabdoid tumor, or MPNST, and w…

This early-stage study is testing whether a treatment made from specific cultivated bacteria (SER-155) is safe and might help control severe diarrhea caused by cancer immunotherapy drugs. It will involve about 15 adults who are experiencing this side effect but have not yet recei…

This study is testing whether a lower dose of the cancer drug brentuximab vedotin can effectively treat certain types of skin lymphoma while potentially causing fewer side effects. It is enrolling adults with mycosis fungoides, Sezary syndrome, or lymphomatoid papulosis who need …

This early-stage study is testing whether combining two oral drugs, revumenib and mezigdomide, is safe and effective for people with specific types of acute leukemia that have returned or not responded to prior treatments. The trial will enroll about 52 participants aged 12 and o…

This study is testing a new drug called ERAS-601 in people with advanced chordoma, a rare type of bone cancer that has continued to grow despite previous treatments. Researchers want to find out if ERAS-601 is safe and if it can help control the cancer by shrinking tumors or stop…

This study is testing whether a lower dose of radiation therapy, given over a shorter time, combined with standard chemotherapy works as well as the current higher-dose radiation treatment for people with HPV-positive throat cancer. The goal is to see if reducing radiation can st…

This study is testing if adding a precise, high-dose radiation treatment to liver tumors helps standard immunotherapy drugs work better for people with advanced lung cancer that has spread to the liver. It will compare the standard drug treatment alone to the drug treatment plus …

This study is testing a new combination of three existing drugs—lenvatinib, pembrolizumab, and fulvestrant—to see if it is safe and effective for people with a specific type of advanced breast cancer that has spread. The main goal is to find the safest dose of this three-drug com…

This study is testing whether alternating between two different drug combinations is safe and effective for people newly diagnosed with standard-risk multiple myeloma. The trial will enroll 65 patients who are eligible for stem cell transplant. Researchers want to see if switchin…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This study aims to understand how well patients recover function and how their bones heal after surgery to remove bone tumors. Researchers will follow 300 patients for three years after their reconstructive surgery, which may use bone grafts or artificial devices. The goal is to …

This study is testing whether adding the chemotherapy drug cyclophosphamide to the immunotherapy drug elranatamab works better for people with multiple myeloma that has returned or stopped responding to other treatments. It is for adults whose cancer has specific features that mi…

This study is testing a personalized cell therapy called ide-cel for people with multiple myeloma that has come back after many treatments and a stem cell transplant. Researchers want to see if the quality of a patient's own immune cells, used to make the therapy, affects how wel…

This study is testing a new immune-stimulating drug, injected directly into the prostate tumor, for men with prostate cancer who are scheduled for surgery. The goal is to see if this approach, sometimes combined with standard hormone therapy, can help the body's own immune system…

This early-stage study is testing whether two experimental drugs, ABBV-637 and ABBV-155, are safe and tolerable when given alone or combined with another drug called ERAS-801. The trial involves 60 adults with recurrent glioblastoma, a fast-growing brain cancer, who have a specif…

This study is testing whether a personalized immune cell therapy called obecabtagene autoleucel (obe-cel) can help prevent relapse in adults with B-cell acute lymphoblastic leukemia who are currently in their first complete remission with no detectable cancer cells. The therapy i…

This study is testing whether adding an experimental drug called tinengotinib to standard prostate cancer medications is safe and effective for men with advanced prostate cancer that has spread and stopped responding to hormone therapy. The trial will enroll 50 participants who a…

This study is testing a new type of radiation therapy called lattice radiation (LRT) for people with large cancer tumors that have spread to soft tissues. It compares LRT to standard radiation to see which is better at shrinking tumors and attracting immune cells to fight the can…

This study is testing whether two immunotherapy drugs (botensilimab and balstilimab) can shrink rectal tumors before surgery. Researchers want to see if this approach works for people with a specific type of rectal cancer that doesn't typically respond well to immunotherapy. The …

This study is testing a new combination of five different treatments for people with advanced stomach or esophageal cancer that has worsened after one prior therapy. The goal is to see if this multi-drug approach can better control the cancer. The treatment includes two immunothe…

This early-stage study is testing the safety of a new cell therapy for advanced stomach and esophageal cancers that have spread to the abdominal lining. Doctors collect a patient's own immune cells, modify them in a lab to better target cancer cells, and then infuse them directly…

This study is testing whether a drug called BIO 300 can help protect the lungs of patients who have both early-stage lung cancer and a separate lung scarring disease (interstitial lung disease) when they receive radiation therapy. The main goal is to see if BIO 300 can prevent se…

This is an early-stage study to find a safe dose of an experimental therapy called MQ710 for people with advanced solid tumors that have returned, spread, or stopped responding to standard treatments. The therapy is a modified virus designed to be injected directly into tumors. R…

This study is testing whether a much shorter, one-week course of targeted pelvic radiation, given alongside standard chemotherapy drugs, is practical for patients to complete. It aims to see if this combined approach is manageable for people with stage III endometrial cancer who …

This study is testing a two-part treatment to prevent high-risk neuroblastoma from returning in patients who are currently in remission. It combines a vaccine designed to train the immune system to attack cancer cells with an oral supplement (β-glucan) that may boost the immune r…

This program provides access to an unapproved drug called L-MTP-PE for people with osteosarcoma (a type of bone cancer). The drug aims to help the body's own immune system fight and control the cancer after surgery. It is for patients whose doctors believe it could be beneficial …

This early-stage study is testing if adding two immunotherapy drugs (cemiplimab and cetuximab) to standard chemotherapy before surgery is safe for people with advanced head and neck cancer. The main goal is to see if this stronger pre-surgery treatment can work well enough that p…

This study is testing whether adding a new drug called ulixertinib to an existing medication (ruxolitinib) is safe and effective for people with myelofibrosis, a rare bone marrow cancer. Researchers will enroll 37 adults who are already taking ruxolitinib but still have significa…

This study aims to help bladder cancer patients recover better after major surgery. It will test if using a small urine drainage tube (stent) or a bowel recovery drug (alvimopan) helps patients leave the hospital sooner and reduces infections. About 530 patients will be randomly …

This study is testing whether a lower dose of radiation can effectively treat metastatic tumors that have a specific genetic change called an ATM mutation. Researchers are recruiting 40 patients to find the minimum radiation dose needed to control these tumors while potentially r…

This study is testing whether adding targeted radiation to the brain after three months of drug therapy works better than using the drug alone for people with a specific type of lung cancer that has spread to the brain. Researchers want to see if this combined approach helps cont…

This is a first-in-human study to test the safety and find the right dose of a new type of CAR T-cell therapy for patients with acute myeloid leukemia (AML) that has come back or not responded to other treatments. The therapy involves modifying a patient's own immune cells to tar…

This early-stage study is testing the safety of a new drug called 2141-V11 for people with non-muscle invasive bladder cancer that hasn't responded to standard BCG therapy and who are not having their bladder surgically removed. Researchers will give the drug directly into the bl…

This study is testing a combination of three drugs—zanubrutinib, obinutuzumab, and venetoclax—for people with untreated CLL or SLL. The main goal is to see how many patients achieve a deep response where no cancer cells can be detected in their blood or bone marrow. It aims to co…

This study is testing whether codrituzumab is safe for children and young adults with solid tumors that have returned or stopped responding to standard treatments. Researchers will give the drug to up to 50 patients aged 1-21 years to check for side effects and see how the body p…

This study is testing if the experimental drug ZEN003694 can help control advanced squamous cell lung cancer in people whose cancer has a specific genetic change called NSD3 amplification. The drug works by blocking certain proteins that cancer cells may need to grow. Researchers…

This early-stage study is testing whether adding the drug abemaciclib to the standard treatment ruxolitinib is safe and more effective for people with myelofibrosis, a serious bone marrow cancer. The trial is for patients who are already taking ruxolitinib but still have signific…

This study is collecting information on patient outcomes after receiving a cord blood transplant using Memorial Sloan Kettering's optimized procedure. It aims to see how well this standard transplant approach works for adults with high-risk blood cancers like leukemia, lymphoma, …

This study is testing if adding an immunotherapy drug called Dostarlimab to standard radiation treatment can help prevent cancer from coming back in women with a specific, harder-to-treat type of advanced endometrial (uterine) cancer. It is for women who have already had surgery …

This study is testing whether the drug enfortumab vedotin can help control advanced adenoid cystic carcinoma, a rare cancer that has returned or spread. Researchers will enroll 34 adults whose cancer has progressed despite previous treatments. The trial will measure how well the …

This study is testing whether using a lower dose of radiation, combined with chemotherapy and planned surgery, can effectively control certain head and neck cancers. The goal is to see if this approach works while potentially reducing treatment side effects. It is for adults with…

This study is testing whether cancer patients can safely receive more of their routine care through video visits from home instead of traveling to the clinic. It involves 1,750 people with breast or prostate cancer who have already had several clinic visits. The goal is to see if…

This study is testing whether adding an anti-inflammatory drug called certolizumab to standard chemotherapy before surgery can help shrink lung tumors more effectively. The goal is to see if this combination leads to better outcomes for patients with stage II or III non-small cel…

This study is testing whether placing tiny radiation seeds during brain surgery can prevent tumors from growing back in people with recurrent brain metastases. Researchers are comparing this approach to standard surgery alone to see which works better at controlling the cancer. T…

This study is testing whether the drug ulixertinib can safely control rare blood cancers called histiocytic neoplasms. Researchers will enroll 38 patients aged 12 and older whose cancer has continued to grow despite previous treatments. The trial focuses on patients whose cancers…

This study is testing whether giving two immunotherapy drugs, cemiplimab and fianlimab, before surgery to remove a kidney is a safe and practical approach. The goal is to see if this treatment can shrink the tumor before the operation. It is for a small group of 10 people with hi…

This study is testing whether a combination of two drugs, azacitidine and venetoclax, can help get rid of very low levels of leukemia cells that remain after standard chemotherapy in adults with acute myeloid leukemia (AML). The goal is to better prepare patients for a bone marro…

This study is testing whether analyzing tissue samples taken right after a liver tumor ablation procedure can help doctors identify any remaining live cancer cells. The goal is to use this information to guide the next steps in treatment for patients with cancer that has spread t…

This study is testing whether combining two targeted drugs is safe and helpful for adults with acute myeloid leukemia (AML) that has returned or not responded to prior treatment, and who have two specific genetic mutations. Researchers will first find the highest dose of the drug…

This study is testing if giving a drug called emapalumab right after diagnosis can help children and young adults with severe aplastic anemia. Aplastic anemia is a rare condition where the bone marrow stops making enough blood cells. Researchers want to see if adding emapalumab e…

This study is testing whether a personalized approach using a special PET scan to select patients for lower radiation doses works as well as standard high-dose radiation for HPV-positive throat cancer. Researchers want to see if this approach causes fewer side effects while maint…

This study is testing whether limiting radiation treatment to just the lymph nodes in the neck, while avoiding the tongue surgery site, can reduce painful mouth sores and other side effects for people with oral tongue cancer. Researchers will enroll 24 patients who have already h…

This study is testing whether a plant-based supplement called isoquercetin can reduce markers in the blood that indicate risk of blood clots in people with ovarian cancer. Researchers will compare the effects of isoquercetin against a placebo in 90 participants who are receiving …

This study is testing whether an experimental drug called tarlatamab can help control advanced prostate cancer that has spread and stopped responding to standard treatments. The trial will enroll 32 men whose cancer tests positive for a specific protein called DLL3. Researchers w…

This study is testing whether the drug ruxolitinib can help control advanced T or NK cell lymphomas that have returned or stopped responding to other treatments. It will enroll about 83 adults whose cancer has progressed after at least one prior therapy. The drug works by blockin…

This study is testing whether a combination of three drugs—pirtobrutinib, venetoclax, and rituximab—can effectively treat people newly diagnosed with Waldenström's macroglobulinemia, a rare blood cancer. The treatment is given for a limited time rather than continuously. Research…

This study is testing whether adding an experimental drug called evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better for people with advanced triple-negative breast cancer who also have metabolic issues like high blood sugar or obesity. About 55 participants w…

This study is testing whether adding two newer drugs (pembrolizumab and trastuzumab) to standard chemotherapy before surgery can better control HER2-positive stomach and esophageal cancers. The goal is to shrink tumors before surgery and prevent cancer from returning. About 49 pa…

This study is testing whether a new combination treatment can safely slow the growth of advanced sarcoma tumors in an arm or leg. It combines a targeted limb chemotherapy procedure with a drug that helps the immune system fight cancer. The goal is to see if this approach can keep…

This study is testing if the drug enzalutamide, alone or combined with mifepristone, can help control a specific type of advanced breast cancer that has spread. It will compare these treatments to standard chemotherapy options to see which is better at delaying cancer growth. The…

This early-stage study aims to find a safe and effective dose of two drugs, ruxolitinib and duvelisib, for adults whose T-cell or NK-cell lymphoma has returned or not responded to prior treatments. The main goal is to determine the highest dose patients can tolerate without sever…

This study is for people with a type of bile duct cancer in the liver that cannot be removed by surgery. It compares standard chemotherapy to the same chemotherapy plus a second drug delivered directly to the liver via a special pump. The goal is to see if the combined treatment …

This study is testing whether a combination of two drugs, avutometinib and defactinib, can help control advanced thyroid cancers that have specific genetic changes and have stopped responding to standard radioactive iodine treatment. The trial will enroll about 30 adults with two…

This study is testing whether a new drug called ivonescimab can help control advanced endometrial or cervical cancer that has continued to grow despite previous treatment. The drug works by targeting two different pathways that cancer cells use to grow and evade the immune system…

This study is testing whether keeping blood pressure extra low during breast cancer chemotherapy is safer and more effective at preventing heart damage than standard blood pressure care. Researchers will compare two different blood pressure targets in 130 women receiving chemothe…

This study is testing whether a blood conservation technique called acute normovolemic hemodilution (ANH) can reduce the need for donor blood transfusions during ovarian cancer surgery. Researchers will randomly assign 86 patients undergoing surgery for advanced ovarian cancer to…

This study is testing whether using a highly focused, high-dose radiation treatment on all visible tumor sites can help people with a limited number of cancer metastases live longer without their disease getting worse. It is for adults with breast cancer or non-small cell lung ca…

This is a small, early-stage study for adults with B-cell leukemia or lymphoma that has come back or not responded to other treatments. The goal is to test the safety of a new two-step approach. First, patients receive a targeted radioactive drug (131-I apamistamab), followed by …

This study is testing whether a new drug called repotrectinib, when given with standard chemotherapy, is safe and effective for children and young adults (up to age 30) whose solid tumors have come back or stopped responding to other treatments. Researchers will first find the sa…

This study is testing whether adding immunotherapy drugs (pembrolizumab with or without olaparib) to standard radiation therapy is safe and more effective at controlling metastatic breast cancer than radiation alone. It is for adults with specific types of breast cancer (triple-n…

This study is testing whether the immunotherapy drug pembrolizumab can help control five specific types of ultra-rare sarcomas that have few treatment options. It will enroll 32 adults whose cancer has returned or spread despite prior treatments. The drug works by releasing the i…

This study is testing whether combining two drugs, abemaciclib and cabozantinib, is safe and effective for people with advanced kidney cancer that has spread and has stopped responding to standard treatments. Researchers will first find the safest dose and then see how well the c…

This study is testing whether special, noninvasive cameras can help doctors more accurately diagnose skin and mouth lesions. The goal is to see if these images can guide treatment and sometimes avoid the need for a biopsy. Researchers will create a large database of images from o…

This study aims to compare two types of imaging scans to see which is better at finding and tracking metastatic lobular breast cancer. Researchers will test a new scan (FES PET/CT) against the standard scan (FDG PET/CT) in 30 adults with this specific cancer type. The goal is to …

This study is testing a new 3D imaging tool designed to help surgeons during head and neck cancer operations. Researchers will use a smartphone app to create 3D models from standard medical scans before surgery. The goal is to see if combining these 3D models with regular scan in…

This study aims to create a simple blood test to find pancreatic cancer at its earliest, most treatable stages and to track how well treatment is working. Researchers are enrolling 700 people, including those with pancreatic cancer, pancreatitis, pancreatic cysts, and healthy vol…

This study is developing a new type of MRI scan to help doctors tell the difference between brain tumors that are growing because cancer is getting worse and tumors that appear larger due to swelling from radiation treatment. The research involves healthy volunteers and patients …

This study is testing a new type of PET scan that uses a special form of iodine (iodine-124) to better measure how much radioactive iodine is taken up by thyroid cancer that has spread. The goal is to see if this scan can more accurately predict which patients will benefit from s…

This study is testing a newer type of eye scanner against a standard one to see if it can take clearer, more detailed pictures of the back of the eye. Doctors want to know if the newer scanner helps them better detect and monitor eye tumors. The study is for adults who already ha…

This study aims to see if people with unexplained weight loss who get lung cancer screening are more likely to have or develop lung cancer than those without weight loss. Researchers will use low-dose CT scans and blood tests to try to detect lung cancer earlier in high-risk smok…

This study is testing a new two-part imaging method to help surgeons see breast cancer tumors more clearly. First, participants get a special MRI scan before surgery. Then, they receive an experimental fluorescent dye (pHLIP ICG) that makes cancer cells glow under a special camer…

This study is testing a new type of imaging scan to see if it can safely and effectively detect small cell lung cancer and similar tumors. The scan uses a special tracer that attaches to a protein called DLL3, which is often found on these cancer cells. Researchers want to see if…

This study is testing whether a combination of two new types of scans and blood tests can detect pancreatic cancer early in people with high-risk pancreatic cysts. The goal is to find a better way to spot cancer without needing invasive surgery. Researchers will enroll 25 adults …

This study is testing a new type of ultrasound imaging that combines multiple techniques to create more detailed pictures of tissue. Researchers want to see if this advanced imaging can better examine pancreatic cancer and thyroid nodules compared to standard ultrasound. The stud…

This study is testing a new, faster type of MRI scan to see if it can provide clearer, more detailed pictures of gynecologic tumors. The goal is to help doctors get better information about the tumor's activity to guide treatment decisions. The study will involve 20 women, some w…

This study is testing a new, non-invasive breath test called an 'electronic nose' to see if it can measure how well lung cancer treatment is working. Researchers will collect breath samples from 50 people with non-small cell lung cancer before and after their standard treatment. …

This study is testing a new imaging device that takes microscopic pictures of spots inside the mouth. Researchers want to see if these pictures can accurately identify oral cancer by comparing them to traditional biopsy results. The goal is to develop a tool that could help docto…

This study aims to improve breast cancer diagnosis in Nigeria by training local radiologists. Using tablet-based mobile health devices, researchers will teach doctors how to perform ultrasound-guided breast biopsies, a more precise method than current options. The goal is to crea…

This early-stage study is testing whether a new imaging tracer made with tiny silica particles can safely help surgeons better see prostate cancer cells during surgery. The tracer is designed to attach to cancer cells and show up on scans, potentially helping surgeons remove more…

This study is testing if a new type of PET/CT scan, called a 68Gallium PSMA-PET/CT scan, can find cancer that has spread in people with advanced bladder cancer or melanoma. Researchers want to see if this new scan works as well as or better than the standard scans doctors current…

This study aims to find the best family-centered program to help Hispanic parents and children lose weight and prevent obesity. Researchers are testing a mobile health intervention that uses text messages and video calls to promote healthy eating and activity habits. The program …

This study is testing whether an educational video increases interest in a preventive surgery to remove the fallopian tubes, which may help lower ovarian cancer risk. Researchers will ask women aged 45+ who are already scheduled for other abdominal surgery to watch the video and …

This study is testing whether a comprehensive prevention program can help drain fluid from the arm and stop lymphedema (chronic arm swelling) from developing. It involves 285 women with breast cancer who are having surgery to remove lymph nodes under their arm. The main goal is t…

This study is testing whether placing small antibiotic beads near breast tissue expanders during reconstruction surgery can prevent infections. Researchers want to see if this local antibiotic delivery reduces the risk of surgical site infections and fluid buildup (seroma) in the…

This study is testing whether the drug mogamulizumab can prevent a serious type of blood cancer called adult T-cell leukemia/lymphoma (ATL) from developing. It is for people who carry the HTLV-1 virus and have specific changes in their immune cells that put them at high risk for …

This study is testing whether changing what people eat can help prevent two early blood cell conditions (MGUS and SMM) from turning into cancer. Researchers will compare a plant-based diet, omega-3 and curcumin supplements, or a placebo in 150 participants over 12 weeks. They're …

This study is testing whether a medication called IgPro20 can help prevent infections in people with multiple myeloma who have low antibody levels. The research focuses on patients receiving bispecific antibody therapy, which can increase infection risk. Participants will be rand…

This study is testing whether adding the drug belumosudil to standard preventive treatments can better protect blood cancer patients from graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will enroll 46 adults who have recently received a transplant and a…

This study is testing two different support methods to help men follow through with their prescribed sexual rehabilitation exercises after prostate cancer surgery. Researchers want to see which approach helps men better stick with their rehabilitation program and improve their er…

This study is testing whether training cancer doctors and nurses in empathic communication skills can help reduce the feelings of stigma often experienced by lung cancer patients. Over 1,200 participants, including healthcare providers and their patients, will take part. The goal…

This study is testing two different walking exercise programs for women receiving chemotherapy for breast cancer. It aims to see which approach is better at improving fitness and reducing cancer-related fatigue. The study will enroll 140 participants to compare a fixed weekly wal…

This small pilot study is testing whether moving a flap of a patient's own fat to the neck area is a safe and practical way to reduce problems that occur after cancer treatment. These problems can include pain, stiffness, swelling, and trouble swallowing. Researchers will also ch…

This study is adapting and testing a program called CONVO for Latinx cancer patients. In the program, oncology nurses have a special conversation with patients about their personal values and goals for care. The goal is to see if these talks help improve communication and the ove…

This study is testing whether a special herbal plaster applied to the skin can be a helpful addition to standard opioid pain medication for people with cancer. Researchers want to see if the plaster is practical and effective for managing pain in a specific area of the body. The …

This study is testing whether a virtual mind-body wellness program can help cancer patients feel better during treatments like chemotherapy or radiation. The program offers online classes in things like meditation and yoga to help manage common side effects like severe fatigue. R…

This study is testing whether acupuncture is a practical and helpful treatment for cancer survivors who have ongoing joint and muscle pain. It will involve 60 non-white or Hispanic women who have finished active cancer treatment but still experience significant pain. The main goa…

This study is testing whether a specially designed anxiety treatment program is practical and helpful for Latino older adults who have cancer and for the family members who care for them. Researchers will work with 60 participants to see if the program reduces anxiety and is some…

This study is testing whether acupuncture is a practical way to help young women get their menstrual periods back after chemotherapy. Researchers will enroll 60 participants who lost their periods due to cancer treatment and randomly assign them to receive acupuncture or wait for…

This study is testing whether a single 60-minute counseling session can help reduce anxiety and depression in breast cancer patients who are waiting to start regular therapy. Researchers want to see if this brief session is helpful and practical for patients to complete. The stud…

This study is adapting a counseling approach called Meaning-Centered Psychotherapy to better serve Latino patients with advanced cancer. Researchers will work with about 285 participants to make the therapy culturally relevant and test if it improves spiritual well-being, reduces…

This study is testing whether virtual music therapy works as well as cognitive behavioral therapy (a type of talk therapy) to reduce anxiety in people who have had cancer. It will involve about 368 participants, including some with advanced cancer. Researchers will see which appr…

This early-stage study is testing whether a single, highly focused dose of radiation can safely treat chronic pain in the chest or abdominal wall. Researchers will give different radiation doses to a small group of adults whose pain hasn't been helped by standard pain medications…

This study is comparing two types of group therapy to help breast cancer survivors manage joint pain caused by their medication. Researchers want to see if these weekly video sessions can reduce pain, improve quality of life, and help people stay on their cancer treatment. The st…

This study is testing different combinations of cancer education, counseling, and peer support meetings designed specifically for Chinese cancer patients and survivors. Researchers want to see which combinations work best and are most practical for improving participants' quality…

This study is testing whether a special red light therapy can safely reduce painful mouth sores caused by chronic Graft-Versus-Host Disease (GVHD). It will involve 44 patients who have had a stem cell transplant and still have mouth sores despite previous treatments. Participants…

This study is testing whether a vaginal suppository called Revaree Plus can improve vaginal health for women experiencing dryness and discomfort during breast cancer treatment. Researchers will enroll 60 women with hormone-receptor positive breast cancer who have completed primar…

This study is testing whether a Spanish-language telehealth program called DESCANSO/REST is practical and helpful for Latino cancer patients struggling with depression, fatigue, and insomnia. Researchers want to see if patients complete the sessions and find them useful. The prog…

This study is testing whether the medication gabapentin should be a standard part of pain management for patients having breast removal surgery (mastectomy). It involves nearly 1,900 patients at a major cancer center. The main goal is to see if using gabapentin around the time of…

This study is testing a mobile app called TEAMWork, designed to help breast cancer patients keep their jobs during and after treatment. The app provides advice for having conversations about cancer with employers and doctors. Researchers are asking about 546 breast cancer patient…

This study is testing whether an herbal formula called Ma-Zi-Ren-Wan (MZRW) can help relieve constipation in people who have survived cancer. Researchers will compare MZRW to a placebo (a dummy pill) over two weeks to see if it increases comfortable bowel movements. They will als…

This study aims to find the most effective aerobic exercise program to improve heart and lung fitness in women who have completed treatment for early-stage breast cancer. Researchers will compare different amounts and durations of exercise to see which plan best helps participant…

This study is testing whether a new 5-session phone therapy program called CARE can better help older adults with cancer who are feeling depressed or distressed. Researchers will compare CARE against standard supportive phone counseling to see which is more effective. The study i…

This study is testing a support program called ICCAN to see if it helps people with cancer complete their treatment and improves their quality of life. Researchers will compare ICCAN to the standard support services offered at New York City hospitals. The study is enrolling about…

This study is adapting a counseling program called Meaning Centered Psychotherapy to be more culturally relevant for Latino adults with advanced solid tumors. Researchers want to understand what affects quality of life for these patients and test if this adapted therapy can help …

This study is testing whether different amounts of aerobic exercise, like walking on a treadmill, can help reduce the side effects of chemotherapy for people with stomach or colon cancers. Researchers want to find the exercise level that is safe, practical, and most helpful for p…

This study aims to compare the long-term quality of life for people with lymphedema who choose to have a specific surgery (vascularized lymph node transfer) versus those who choose non-surgical management. It will follow 600 adults with arm or leg swelling to see which approach h…

This study is testing new MRI and CT imaging methods to help doctors better plan radiation therapy and monitor how tumors respond during treatment. Researchers are evaluating a combined MRI-radiation machine called MR-Linac that could improve image quality during radiation delive…

This study is testing whether advanced MRI scans can better identify which areas of a malignant brain tumor are most likely to grow back after standard treatment. Researchers will enroll adults with glioma to see if these detailed images can safely help guide future radiation the…

This study is testing a new method to find early signs that aggressive B-cell lymphoma might spread to the brain and spinal cord (central nervous system). Researchers will analyze spinal fluid from 50 high-risk patients using a sensitive DNA test to see if it can detect cancer ce…

This study aims to understand how breast cancer treatments affect ovarian health and future fertility in premenopausal women with BRCA gene mutations. Researchers will track hormone levels in the blood before, during, and after treatment to see how chemotherapy and hormone therap…

This study examines past medical records of 4,000 people who had surgery for esophageal cancer. Researchers want to understand how different surgical approaches and treatment timing affect long-term survival. The goal is to learn from historical data to improve future cancer care…

This study aims to find out which small thyroid cancers are likely to grow and require treatment. Researchers will follow 750 patients who have chosen to monitor their small cancer instead of having immediate surgery. By tracking the patients and analyzing tumor samples, the stud…

This study aims to measure how much radiation doctors are exposed to when performing robotic-assisted lung biopsies. Researchers will observe 350 standard procedures where doctors use robotic tools to sample lung tissue. Doctors will wear special badges that track their radiation…

This study aims to understand the inherited genetic factors that cause lymphoma, leukemia, and related cancers within families. Researchers are recruiting individuals and their family members who have a personal or family history of these diseases. The main goal is to collect DNA…

This study aims to learn how skin conditions related to cancer or its treatment affect patients' quality of life. Over 1,000 cancer patients and survivors will fill out questionnaires about their skin-related well-being. The goal is to gather information to help improve future ca…

This research aims to understand why colorectal cancer is increasing in younger adults by collecting blood, tissue, and stool samples. The study will compare samples from people aged 18-49 with colorectal cancer to samples from healthy people of the same age. Researchers will ana…

This international registry aims to collect health information from 500 people with painful bone metastases to better understand survival patterns and treatment approaches. Participants are adults (22+) with confirmed bone metastases requiring treatment like radiation or surgery.…

This study aims to create a long-term registry to understand what happens to people with Cushing's syndrome after they receive standard treatments like surgery, medication, or radiation. Researchers will follow 300 patients aged 14 and older during their routine care to collect d…

This study aims to understand if breast cancers in women with BRCA2 gene mutations respond differently to hormone therapy before surgery compared to cancers in women without these mutations. Researchers will measure a specific protein (Ki67) in tumor samples before and after at l…

This study is testing a new device called an 'electronic nose' that analyzes a person's breath. Researchers want to see if the chemical patterns in breath can show how well standard treatment is working for malignant pleural mesothelioma, a type of lung cancer. They will compare …

This study aims to find the best remote language interpreter method for Spanish- and Mandarin-speaking breast cancer patients with limited English skills. Researchers will compare three different interpreting approaches during doctor visits to see which one makes the fewest trans…

This study aims to understand the barriers that prevent eligible blood cancer patients from receiving a potentially curative stem cell transplant. Researchers will observe over 1,300 adults with acute leukemia, myelodysplastic syndrome, or myeloproliferative neoplasms to track wh…

This study aims to better understand how rectal cancer patients respond to standard chemotherapy and radiation treatments. Researchers will analyze participants' blood, tissue samples, and medical scans to learn how cancers change during treatment. The goal is to find patterns th…

This study aims to understand the genetic changes in cancer cells by analyzing leftover tumor tissue and a normal sample from patients. The goal is to identify specific mutations that might predict how a tumor will respond to certain drugs. Researchers will track how these genes …

This study aims to collect health and activity data from patients' smartphones to build a large research database. Researchers want to see if patterns in daily physical data can tell us something about cancer risk, diagnosis, or how patients respond to treatment. The study includ…

This study is creating a global registry to collect health information from people with large, dark birthmarks present at birth (LCMN) or a related condition where similar cells are found in the brain (NCM). The goal is to gather data on how the disease progresses and what treatm…

This study is testing a new questionnaire designed to better understand the experiences of teens and young adults (ages 15-39) with cancer. Researchers want to see if the questionnaire is reliable and works well for both English and Spanish speakers. The goal is to create a bette…

This study is creating a large international registry to collect real-world data on patients with early-stage lung cancer who undergo a lung-sparing surgery called segmentectomy. It aims to track how well patients do over 3 and 5 years after this specific surgery. The goal is to …

This study is creating a database of health information from people diagnosed with desmoplastic small round cell tumor (DSRCT), a rare and aggressive cancer. Researchers will collect medical history and ongoing health data from up to 250 participants of any age. The goal is to ga…

This study aims to see if a new type of MRI scan gives consistent results when repeated. Researchers are testing the scan, which uses a special imaging agent, in people with solid tumors like breast, prostate, or brain cancer. The goal is to understand if this scan reliably shows…

This study is creating a large registry of DNA and health information from people with kidney cancer, their family members, and healthy volunteers. The goal is to collect data to help researchers understand the genetic factors involved in kidney cancer. This knowledge could lead …

This study aims to understand how pancreatic cancer communicates and spreads by examining tiny particles called exosomes in the blood and tissue. Researchers will compare samples from 181 patients with pancreatic cancer to those with non-cancerous pancreatic conditions to establi…

This study aims to understand how CAR-T therapy affects thinking skills, memory, and brain structure in adults with lymphoma. Researchers will follow 120 patients receiving standard CAR-T treatment, using cognitive tests and brain scans over time. The goal is to learn about poten…

This study aims to understand the genetic and biological characteristics of neuroblastoma tumors and how they relate to a patient's outcome. Researchers will analyze tumor, blood, and bone marrow samples from over 2,000 participants to identify genetic markers. The goal is to lea…

This study aims to understand why some stomach changes turn into cancer while others don't. Researchers will follow 3,200 people with various stomach conditions, healthy individuals, and cancer patients to compare their characteristics over time. The goal is to identify risk fact…

This study is testing a special type of ultrasound imaging to see if it can detect early changes in vaginal tissue caused by a standard radiation treatment for endometrial cancer. The goal is to see if this imaging can predict which patients might develop side effects like vagina…

This study aims to create a registry to better understand Erdheim-Chester disease and related rare conditions. Researchers will collect health information from 500 participants to learn how these diseases affect people's lives and how different treatments work over time. Some par…

This study aims to understand how chemotherapy and radiation treatments affect the ability to have children and sexual health in younger adults with colorectal cancer. Researchers will track hormone levels and ask participants about their reproductive and sexual health over time.…

This study aims to build a DNA registry to better understand testicular and germ cell tumors. Researchers will collect genetic and health information from 1,000 people, including patients, their family members, and unrelated healthy individuals. By comparing these groups, they ho…

This study aims to understand how often early-stage uterine cancer comes back after standard surgery that includes a sentinel lymph node biopsy. It will also track how often patients develop long-term leg swelling (lymphedema) as a side effect of this procedure. Researchers will …

This study aims to understand how cancer treatments affect women's sexual function and ability to have children. Researchers will follow 475 women with breast cancer or lymphoma, collecting questionnaires and optional blood tests over time. The goal is to learn about these side e…

This study aims to better understand how liver tumors respond to a targeted radiation treatment called Y90 radioembolization. Researchers will collect small tissue samples from participants' tumors after treatment to examine the effects. The findings could help improve how this t…

This study is testing a new imaging agent used with PET/CT scans to see if it can better detect and measure certain blood cancers and rare tumors. It involves about 30 adult patients with conditions like non-Hodgkin lymphoma, multiple myeloma, or specific rare diseases. The goal …

This study aims to understand how short-term dietary changes affect gut bacteria in people with early, pre-cancerous blood conditions (MGUS or SMM). Researchers will remotely enroll 200 participants across the US to follow a plant-based diet or take specific supplements for two w…

This study is testing a new training program called Hematolo-GIST, designed to help lymphoma doctors communicate more effectively with their patients. It involves 48 doctors and their patients with a specific type of aggressive lymphoma. The main goal is to see if the training is…

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect surveys, blood, and tissue samples from 800 participants in South Florida to look for genetic and lifestyle factors. The goal is to gather knowledge that may he…

This study looks at whether exercise after cancer treatment affects how long survivors stay cancer-free and their overall survival. Researchers will analyze existing health records from 1,000 adult cancer survivors who completed treatment at least 3 months ago. The goal is to und…

This study aims to understand how a bladder cancer drug called enfortumab vedotin affects patients' nerves. Researchers will follow 50 adults with advanced bladder cancer who are starting this treatment. They will use nerve tests to measure changes over 12-15 weeks to learn about…

This study is testing whether a new decision-making tool is practical to use in a future, larger trial. The tool is designed to help breast cancer patients and their surgeons make shared, informed decisions about reconstruction surgery after a mastectomy. Researchers will enroll …

This study is testing a program to screen cancer patients for emotional distress and connect those who need help with mental health services. It involves 50 English- or Spanish-speaking adults with a new solid tumor cancer diagnosis at a specific NYC hospital. The goal is to see …

This study aims to understand the support needs of family and friends who provide unpaid care for people with rare histiocytic diseases like Erdheim-Chester disease. Researchers will survey 250 caregivers to learn about their challenges and quality of life. The goal is to gather …

This study is testing two new digital approaches to improve cancer genetic counseling. The first part helps doctors contact family members of a patient with a cancer gene to encourage them to get tested. The second part helps patients and their doctors stay updated when a genetic…

This study aims to understand why some patients experience sudden drops in blood pressure after receiving anesthesia before surgery. Researchers will examine heart function and blood flow in 250 adults undergoing surgery with general anesthesia. The goal is to identify the mechan…

This study aims to build a large database of information about colorectal cancer in adults under 50. Researchers will collect data from younger patients and compare it to data from older patients to learn how the disease might differ. The goal is to gather knowledge that can guid…

This study aims to understand how women with BRCA1 or BRCA2 gene mutations react to additional genetic testing that provides more detailed risk information. Researchers want to see how this extra information affects their healthcare decisions, particularly whether they choose pre…

This study aims to create better educational materials about genetic testing for cancer patients who speak different languages and come from diverse cultural backgrounds. Researchers will work with 445 patients who have breast, ovarian, prostate, pancreatic, or colorectal cancer …

This study aims to learn more about what factors influence breast cancer risk and how patients fare after diagnosis. Researchers will collect blood and tissue samples from 750 women and ask them to complete surveys during their regular medical care. The study does not provide any…

This study aims to understand how men with BRCA1/2 gene mutations respond to additional genetic risk information when making decisions about prostate cancer screening. Researchers will survey 150 men without prostate cancer who carry these mutations to learn how this information …

This study aims to discover new genes that make people more likely to get cancer, especially when it runs in families. Researchers are enrolling 1,500 adults and children who either have cancer themselves or have a family history suggesting inherited risk. By analyzing participan…

This study is testing new MRI scanning methods to see if they can provide better information about head, neck, and thyroid cancers. Researchers want to find specific signs on the MRI scans, called biomarkers, that might predict how well a tumor will respond to treatment early on.…