Memorial Sloan Kettering Cancer Center

This early-stage study tests whether two experimental drugs, ABBV-637 and ABBV-155, are safe when given alone or with another drug called ERAS-801 for people whose glioblastoma has come back. About 60 adults with a specific type of brain tumor (EGFR gene amplified) will take part…

This study tests whether giving the drug trastuzumab deruxtecan before routine surgery can shrink tumors in people with a specific type of lung cancer (HER2-amplified or HER2-mutated non-small cell lung cancer). About 14 adults with stage II to IIIB lung cancer will receive the d…

This study looks at whether giving hormone therapy before surgery helps women with a certain type of breast cancer (invasive lobular carcinoma) have cleaner surgical results. The goal is to see if this approach lowers the chance of cancer cells being found at the edges of removed…

This study tests a new drug called ivonescimab combined with standard chemotherapy and precise radiation (SRS) for people with non-small cell lung cancer that has spread to the brain. The goal is to find a safe dose and see if it helps control the brain tumors. About 53 adults wi…

This study is for people with HPV-related throat cancer who have had or will have surgery. Researchers will use a blood test that looks for cancer DNA (HPV ctDNA) to decide if radiation therapy is needed. In one group, patients with no detectable cancer DNA after surgery will ski…

This study tests a combination of three drugs (avutometinib, defactinib, and letrozole) in 20 women with low-grade serous ovarian cancer who cannot have surgery right away. The goal is to see if the drugs can shrink tumors and how safe they are. Participants will take these medic…

This study is testing whether the drug enasidenib is a safe and effective treatment for a rare type of lymphoma called angioimmunoblastic T-cell lymphoma (AITL) that has a specific genetic change (IDH2 mutation). Researchers will give enasidenib either by itself or combined with …

This early-stage study is testing whether adding the drug abemaciclib to standard radiation therapy is safe for people with advanced breast cancer that has spread to the bones. Researchers want to find the highest dose of abemaciclib that can be given safely alongside radiation. …

This study is testing two different drug treatments to see if they can reduce harmful inflammation in people with severe immune system disorders, making them better prepared to receive a stem cell transplant. Researchers want to know if these treatments help the donated stem cell…

This study is testing whether adding the drug belumosudil to standard preventive treatments can better protect blood cancer patients from graft-versus-host disease (GVHD) after a stem cell transplant. Researchers will enroll 46 adults who have recently received a transplant and a…

This early-stage trial is testing a personalized cell therapy called lifileucel for patients with advanced uveal melanoma, sarcoma, or liposarcoma. Doctors take a patient's own immune cells from a tumor, grow large numbers of them in a lab, and then infuse them back into the pati…

This study is testing whether weight loss medications (tirzepatide or semaglutide) are practical and safe for endometrial cancer patients who are overweight or have diabetes while they undergo chemotherapy. Researchers want to see if patients can complete the treatment, monitor s…

This study is testing if adding an immunotherapy drug called dostarlimab to standard radiation treatment is safe and effective for preventing cancer from returning. It is for women with a specific type of advanced endometrial cancer who have recently had surgery. The goal is to s…

This study aims to find out if the cancer drug trastuzumab deruxtecan (T-DXd) can get into brain tumors when given through an IV. Researchers will measure how much of the drug reaches the tumor during surgery in 30 adults with certain HER2-positive brain cancers or recurrent glio…

This study aims to find the best family-centered program to help Hispanic parents and children achieve healthy weight loss and prevent obesity. Researchers are testing a mobile health intervention that uses text messages and video calls to promote better eating and activity habit…

This study tests a special mental health program called DESCANSO/REST for Spanish-speaking Latino cancer patients who feel depressed, have trouble sleeping, or feel very tired. The program is delivered through telehealth (video or phone calls) and includes up to 8 sessions. The m…

This study tests a new phone-based therapy called CARE for older adults (70+) with cancer who feel depressed or distressed. The therapy involves five phone sessions designed to address aging and cancer-related worries. Researchers will compare CARE to standard supportive counseli…

This study tests a support program for Chinese cancer patients and survivors. It combines education sessions, counseling, and peer support groups to see which mix works best. The goal is to improve quality of life. About 64 people from New York and New Jersey who speak Mandarin w…

This study is creating a database of information from people diagnosed with colorectal cancer before age 50. Researchers will use this data to compare young-onset and later-onset colorectal cancer, and to support future research. The study does not test any new treatment or drug.

This study aims to better understand how rectal cancer responds to standard chemotherapy and radiation treatments. Researchers will collect blood, tissue, and scan data from 30 patients undergoing standard treatment to learn how the body reacts. The goal is to find patterns that …