New drug combo aims to tackle lung cancer brain spread

NCT ID NCT07535463

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called ivonescimab, given with standard chemotherapy and focused radiation (SRS), for people with non-small cell lung cancer that has spread to the brain. The goal is to find the safest dose and see if it helps control the brain tumors. About 53 adults with at least one brain metastasis will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ivonescimab (an immunotherapy drug) given with chemotherapy and stereotactic radiosurgery (focused radiation)
What this could lead to: If it works, this could offer a new treatment option for people with lung cancer that has spread to the brain, potentially improving control of brain tumors.
What could go wrong: This is an early-phase trial (Phase 1/2) with only 53 participants, so the benefits are uncertain. The drug may cause side effects, and the combination with radiation could increase risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (All Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITING

Rockville Centre, New York, 11553, United States
Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

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