New drug targets rare lung cancer gene in small trial
NCT ID NCT05607108
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial is testing a drug called ZEN003694 in 13 people with advanced squamous cell lung cancer that has a specific gene change (NSD3 amplification). The drug works by blocking certain proteins that may help the cancer grow. Researchers want to see if it can shrink tumors or slow the disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZEN003694 (a BET inhibitor drug)
- What this could lead to
- If it works, this could point toward a new treatment option for people with a specific type of advanced lung cancer that has a certain gene change.
- What could go wrong
- This is a small, early-phase trial with only 13 participants, so results may not apply widely. The drug may not shrink tumors or could cause side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Memorial Sloan Kettering Bergen (All Protocol Activities)
RECRUITINGMontvale, New Jersey, 07645, United States
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Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITINGNew York, New York, 10065, United States
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Memorial Sloan Kettering Monmouth (All Protocol Activities)
RECRUITINGMiddletown, New Jersey, 07748, United States
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Memorial Sloan Kettering Nassau (All Protocol Activities)
RECRUITINGUniondale, New York, 11553, United States
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Memorial Sloan Kettering Suffolk-Commack (All Protocol Activities )
RECRUITINGCommack, New York, 11725, United States
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Memorial Sloan Kettering Westchester (All Protocol Activities)
RECRUITINGHarrison, New York, 10604, United States
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Memorial Sloan Kettering at Basking Ridge Limited Protocol Activities
RECRUITINGBasking Ridge, New Jersey, 07920, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood test could reveal how lung cancer evolves during treatment
- New drug IDP-001 takes on advanced cancers in early trial
- CRISPR Gene-Edited immune cells aim to fight lung cancer – but trial never started
- Engineered immune cells take on Hard-to-Treat lung cancer
- New combo therapy aims to boost lung cancer fight
- Custom-Made vaccine takes on tough cancers in early trial