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Bacteria cocktail aims to tame immunotherapy side effects

NCT ID NCT06801067

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-stage trial tests whether SER-155, a mix of 16 live bacteria taken by mouth, can safely treat severe diarrhea and colon inflammation caused by cancer immunotherapy. The study will enroll 15 adults who have developed these side effects. The main goal is to check safety, but researchers will also see if the treatment can reduce symptoms without needing immune-suppressing drugs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
SER-155 (a mixture of 16 live bacteria taken by mouth)
What this could lead to
If it works, this could offer a safer, non-immunosuppressive first treatment for severe diarrhea caused by cancer immunotherapy.
What could go wrong
This is a very early Phase 1 trial with only 15 people, so it is primarily testing safety, not effectiveness. The treatment may not work or could cause side effects like bloodstream infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

diarrheal disease enterocolitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DIARRHEA ENTEROCOLITIS

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Memoral Sloan Kettering at Basking Ridge (Limited Protocol Activities)

    RECRUITING

    Basking Ridge, New Jersey, 07920, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Bergen (All Protocol Activities)

    RECRUITING

    Montvale, New Jersey, 07645, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Cancer Center (All Protocol Activities)

    RECRUITING

    New York, New York, 10065, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Monmouth (All Protocol Activities)

    RECRUITING

    Middletown, New Jersey, 07748, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Nassau (Limited protocol activities)

    RECRUITING

    Rockville Centre, New York, 11553, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Suffolk-Commack (Limited protocol activity)

    RECRUITING

    Commack, New York, 11725, United States

    Contact Phone: •••-•••-••••

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    RECRUITING

    Harrison, New York, 10604, United States

    Contact Phone: •••-•••-••••

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