New short radiation regimen aims to cut side effects in breast cancer treatment

NCT ID NCT04084730

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is testing whether a shorter, higher-dose radiation treatment (APBI) given over just three days is safe and effective for women with early-stage breast cancer or DCIS who have had a lumpectomy. The goal is to see if this approach causes fewer or milder side effects compared to standard longer radiation courses. The trial is currently recruiting 280 women aged 45 and older.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Accelerated Partial Breast Irradiation (APBI) - a type of radiation therapy
What this could lead to: If successful, this could offer a more convenient and less toxic radiation option for women with early breast cancer after lumpectomy.
What could go wrong: This is a phase 2 trial with only 280 participants, so results are preliminary. There is a risk of higher toxicity with the shorter radiation schedule.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast ductal adenocarcinoma breast neoplasm ductal breast carcinoma in situ invasive ductal breast carcinoma invasive lobular breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER DCIS DCIS GRADE 1 DCIS GRADE 2 INVASIVE DUCTAL BREAST CARCINOMA INVASIVE DUCTAL CARCINOMA, BREAST

Contacts and locations

Locations

Baptist Alliance Miami Cancer Institute
RECRUITING

Miami, Florida, 33143, United States
Memorial Sloan Kettering Basking Ridge
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10021, United States
Memorial Sloan Kettering Commack
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester
RECRUITING

Harrison, New York, 10604, United States
Norwalk Hospital
RECRUITING

Norwalk, Connecticut, 06850, United States

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