New vaccine combo aims to outsmart neuroblastoma relapse

NCT ID NCT06057948

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 29, 2026 · Updated 3 times

Summary

This Phase II trial tests a bivalent vaccine (with an immune booster) plus two different schedules of oral β-glucan in 94 people with high-risk neuroblastoma who are in complete remission. The goal is to see which schedule triggers stronger antibodies against the cancer, potentially keeping the disease from coming back. Participants are randomly assigned to one of two β-glucan schedules alongside the vaccine.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: bivalent vaccine with OPT-821 (QS-21) adjuvant and oral β-glucan
What this could lead to: If successful, this could lead to a more effective maintenance therapy to keep high-risk neuroblastoma in remission and reduce relapse risk.
What could go wrong: This is an early Phase II trial with only 94 participants, so results may not apply broadly. The vaccine aims to boost antibodies, but it's unclear if that translates to better long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIGH-RISK NEUROBLASTOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

neuroblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH-RISK NEUROBLASTOMA METASTATIC NEUROBLASTOMA NEUROBLASTOMA

Contacts and locations

Locations

Memorial Sloan Kettering Bergen (Consent Only)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Monmouth (Consent Only)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau (Consent Only)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Suffolk-Commack (Consent only)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering Westchester (Consent only)
RECRUITING

Harrison, New York, 10604, United States
Memorial Sloan Kettering at Basking Ridge (Consent only)
RECRUITING

Basking Ridge, New Jersey, 07920, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.