Can a single radiation type spare prostate cancer patients from extra side effects?

NCT ID NCT07751159

Recruiting now Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Aug 07, 2026 · Last updated Aug 13, 2026 · Updated 2 times

Summary

This trial tests two ways of delivering radiation for men with high-risk prostate cancer that has not spread. One approach uses a standard combination of brachytherapy (a temporary radioactive implant) plus SBRT (precise external beams). The other uses SBRT alone. The goal is to see whether skipping the brachytherapy boost reduces short-term urinary symptoms while still controlling the cancer. The study tracks patient-reported urinary function at three months to compare the two strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: radiation therapy (SBRT alone vs. HDR brachytherapy boost plus SBRT)
What this could lead to: If SBRT alone works as well as the combined approach, it could offer a simpler radiation option with fewer urinary side effects for men with high-risk prostate cancer.
What could go wrong: This is a phase 2 trial with 126 participants, so results are preliminary. SBRT alone might not control the cancer as effectively as the standard combination, and side effects can still occur.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for HIGH RISK PROSTATE CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIGH RISK PROSTATE CANCER NON-METASTATIC PROSTATE CANCER PROSTATE CANCER PATIENTS

Contacts and locations

Locations

Memorial Sloan Kettering Cancer Center (All Protocol Activites)
RECRUITING

New York, New York, 10065, United States
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities)
RECRUITING

Commack, New York, 11725, United States
Memorial Sloan Kettering at Basking Ridge (Limited Protocol Activities)
RECRUITING

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering at Bergen (Limited Protocol Activities)
RECRUITING

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering at Monmouth (Limited Protocol Activities)
RECRUITING

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering at Nassau (Limited Protocol Activities)
RECRUITING

Uniondale, New York, 11553, United States
Memorial Sloan Kettering at Westchester (Limited Protocol Activities)
RECRUITING

Harrison, New York, 10604, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.