Memorial Sloan Kettering Cancer Center

This study tested a combination of two oral drugs, copanlisib and ibrutinib, for people with a rare and aggressive brain cancer called primary central nervous system lymphoma that had come back or stopped responding to other treatments. The main goals were to find a safe dose and…

This study tested a drug called ibrutinib for adults with lymphoma that starts in or spreads to the brain and spinal cord. The main goals were to find the safest dose of ibrutinib and to see if it helped control the cancer when given alone or with standard chemotherapy. Researche…

This study tested whether adding a drug called romidepsin after a stem cell transplant could help patients with T cell lymphoma stay in remission longer. The trial involved 47 patients who had already achieved a partial or complete response to initial chemotherapy. Researchers fo…

This small, early-stage study tested whether a drug called enasidenib could safely improve low blood cell counts in people with a condition called CCUS. CCUS involves abnormal blood cells and low counts but is not yet cancer, though it can increase the risk of developing blood ca…

This early-stage study tested whether higher doses of targeted radiation therapy could be safely given alongside chemotherapy to treat bladder cancer. Researchers worked with 19 patients who had bladder cancer that hadn't spread to other parts of the body. The main goal was to fi…

This study tested a combination of two drugs, talazoparib and temozolomide, for men with advanced prostate cancer that had spread and stopped responding to standard hormone therapies. The first part of the study aimed to find the safest dose, and the second part tested how well t…

This study tested whether a combination of immunotherapy drugs (Hu3F8 and GM-CSF) plus a vitamin A-like drug (isotretinoin) could help prevent cancer from coming back in children with high-risk neuroblastoma who had achieved their first remission. The trial involved 59 patients w…

This study tested a new treatment strategy for people with a specific type of advanced lung cancer. After initial chemo and radiation, patients with tiny amounts of leftover cancer in their blood were assigned to either continue their current immunotherapy drug (durvalumab) or sw…

This early-stage study tested whether combining two targeted cancer drugs (dacomitinib and osimertinib) is safe for people with advanced lung cancer that has spread and has a specific genetic change (EGFR mutation). The trial involved 22 patients who hadn't previously received th…

This study tested whether doctors could get the same good results treating multiple myeloma with fewer side effects by using drugs in a specific order. Researchers started patients with two drugs, then only added a third drug if the cancer wasn't responding well enough. The goal …

This study tested a new method to make radiation therapy for lung cancer more accurate. Small beacon devices were implanted near the tumor to track its exact location while patients held their breath during treatment. Researchers wanted to see if this approach was practical and s…

This study tested whether a specific pump and catheter system was a safe way to deliver chemotherapy directly into the liver for patients with colorectal cancer or cholangiocarcinoma that had spread to the liver. The goal was to see if this method could control the cancer in the …

This study aimed to find the best way to use the drug pomalidomide for patients whose multiple myeloma has returned or stopped responding to treatment. It compared two approaches: a stem cell transplant followed by the drug, versus staying on a three-drug combination. The goal wa…

This small pilot study tested whether an oral drug called BGJ398 could shrink tumors in patients with a specific type of recurrent bladder cancer. It involved 4 adults whose cancer had returned after standard treatment and who had a particular genetic mutation. The goal was to se…

This study tested a new strategy for controlling advanced lung cancer that has spread. It aimed to see if using a sensitive blood test to detect tiny amounts of leftover cancer could guide doctors to use targeted radiation or surgery on the remaining tumors. The goal was to see i…

This study tested the safety of adding an oral drug called rucaparib to the standard radiation therapy given after surgery. It involved 31 women with a hard-to-treat type of breast cancer that had not fully disappeared after initial chemotherapy. The main goal was to find a safe …

This early-stage study tested a combination of two drugs, vemurafenib and copanlisib, in patients with a specific type of advanced thyroid cancer that had stopped responding to standard radioactive iodine therapy. The main goals were to find the safest dose of the drug combinatio…

This study tested whether adding the drug panitumumab to standard chemotherapy could help people with colorectal cancer that had spread to their liver stay cancer-free longer after surgery. It involved 75 patients whose cancer had been surgically removed from the liver and who ha…

This study tested whether it was practical to give a special nutrition shake to ovarian cancer patients in the days before their major surgery. Researchers wanted to see if patients could and would follow the program. The goal was to gather information to see if a larger study on…

This study tested whether two drugs, amivantamab and lazertinib, could help control advanced lung cancer that has an EGFR mutation and has spread to the brain or spinal fluid. It was for patients whose cancer had gotten worse or spread to the central nervous system despite previo…

This study tested whether two immunotherapy drugs, nivolumab and ipilimumab, could help control advanced salivary gland cancer that had returned or spread. The trial involved 64 adults whose cancer could not be cured with surgery or radiation. Researchers measured how well the co…

This study tested whether combining two existing cancer drugs, fulvestrant and abemaciclib, could help control recurrent endometrial cancer that is sensitive to hormones. It involved 28 postmenopausal patients whose cancer had returned or persisted after prior treatments. The mai…

This study tested whether a more targeted form of radiation therapy could reduce damage to breast implants in women who had reconstructive surgery after breast cancer. Researchers compared a new technique using many small, precise radiation beams to the standard method, hoping it…

This small, early-stage study aimed to find out if it was safe to add one or two immunotherapy drugs (nivolumab and ipilimumab) to the standard chemotherapy used for advanced ovarian, fallopian tube, or primary peritoneal cancer. It involved 27 patients with advanced disease who …

This study tested whether the drug nivolumab could safely prevent a type of aggressive brain lymphoma from growing back. It was for patients who had completed initial chemotherapy but still had signs of lingering cancer in their spinal fluid. The goal was to see if this maintenan…

This study tested a drug called vemurafenib in 36 adults whose hairy cell leukemia had returned or didn't respond to standard treatments. The main goal was to see how well the drug could eliminate leukemia cells from the blood and how safe it was. Researchers measured the drug's …

This study tested whether a precise form of radiation called proton therapy could control head and neck cancer that had come back after previous radiation. It involved 87 adults whose cancer was not suitable for surgery or who chose not to have surgery. The main goals were to see…

This study tested whether an oral medication called regorafenib could help control advanced adenoid cystic carcinoma, a rare cancer. It involved 38 adults whose cancer had returned or spread and was no longer treatable with surgery or radiation. Researchers gave patients a lower …

This study tested whether adding the immunotherapy drug pembrolizumab to standard radiation or tumor ablation could help control metastatic colorectal cancer. It involved 34 patients whose cancer had spread and who had already tried at least two standard treatments. Researchers w…

This study tested a new electronic device that delivers radiation directly to the skin's surface to treat early-stage basal cell and squamous cell carcinomas. It involved 36 participants aged 60 and older to see how well the treatment worked, how safe it was, and what the cosmeti…

This study tested which of two radiation approaches works better to control cancer that has spread to the fluid-filled spaces around the brain and spine. One method treats the entire fluid system with proton radiation, while the other targets only symptomatic areas with photon ra…

This study tested whether using a smaller dose of radiation could still effectively control high-risk neuroblastoma, a serious childhood cancer, while aiming to reduce long-term side effects. It involved 78 children and young adults who had already received chemotherapy and surge…

This study tested whether a combination of three hormone-blocking drugs, given before, during, and after a short, high-dose course of targeted radiation, could effectively prevent prostate cancer from coming back in men with very high-risk disease. It involved 64 men whose cancer…

This study tested a combination of three drugs (ibrutinib, rituximab, and lenalidomide) for adults with lymphoma that had returned or stopped responding to treatment in the brain or spinal cord. The main goal was to find the highest safe dose of this combination. Researchers also…

This study tested if a newer, targeted drug called brentuximab vedotin could replace a harsh, multi-drug chemotherapy regimen (called ICE) as the first step before a stem cell transplant for patients whose Hodgkin lymphoma had returned or didn't respond to initial treatment. The …

This study tested whether combining three drugs (carfilzomib, lenalidomide, and dexamethasone) is safe and effective for people newly diagnosed with multiple myeloma, a cancer of plasma cells in the bone marrow. Researchers worked with 29 participants to find the highest dose pat…

This study tested different follow-up methods to help New York City taxi drivers control high blood pressure and reduce cancer risks. Researchers worked with 166 male taxi drivers who had high blood pressure, providing health education, referrals, and support through technology. …

This study aimed to find better ways to detect heart damage in people who survived Hodgkin lymphoma after receiving chest radiation treatment. Researchers compared two heart tests—a cardiac MRI and a stress echocardiogram—to see which one was more effective at spotting early hear…

This study tested whether a device called Nevisense could provide helpful information about unusual moles during routine skin checks. It involved 40 adults with over 100 moles and at least three large moles, a condition that increases skin cancer risk. Researchers used the device…

This study aimed to find the best way to screen healthy people for colon cancer. It directly compared two common methods: a one-time colonoscopy versus taking an annual stool test (FOBT). Nearly 5,000 participants aged 50-69 were randomly assigned to one of these screening approa…

This study tested whether a special green dye could help surgeons see the first lymph nodes that ovarian cancer might spread to. Researchers injected the dye into the ovaries of 48 women during surgery to see if it would travel to and highlight these key lymph nodes. The goal was…

This study tested a new scanning method to predict how well standard radioactive iodine treatment works for thyroid cancer that has spread. Researchers used a different radioactive tracer (124-I) with PET scans to measure how much radiation would reach each tumor before giving th…

This first-in-human study tested the safety of a new dye called Illuminare-1, which is designed to glow and highlight nerve structures during prostate cancer surgery. The goal is to help surgeons see and avoid damaging important nerves, which can lead to side effects like inconti…

This small, early-stage study tested a new type of combined PET and MRI scan to see if it could take clearer pictures of brain tumors. It involved 5 adult patients with new or suspected returning brain tumors who were already scheduled for treatment. The goal was to gather initia…

This study tested a new type of imaging scan to see if it could more accurately find prostate cancer that had spread to other parts of the body, particularly the bones. Researchers compared this experimental scan against standard scans in 77 men with advanced prostate cancer. The…

This large, completed study aimed to find out which of two commonly used antibiotics works better at preventing surgical site infections after a major pancreatic surgery called pancreatoduodenectomy. Nearly 1,000 adult patients scheduled for this surgery were randomly assigned to…

This study tested whether a gel called Oleogel-S10 helps heal skin irritation caused by radiation therapy in breast cancer patients. Eighteen participants with moderate-to-severe skin reactions applied either the study gel or a standard steroid cream. Researchers measured whether…

This study tested if a drug called colesevelam could safely reduce diarrhea caused by lenalidomide, a common maintenance therapy for multiple myeloma. It involved 25 adult patients with myeloma who were experiencing this specific side effect. The main goal was to see if their dia…

This study tested two different ways to provide extra care for adults 65 and older with head and neck cancer who were receiving chemotherapy and radiation. The goal was to see if specialized support from geriatric doctors could help manage treatment side effects better and reduce…

This study tested the safety of a shorter radiation schedule called 'Quad Shot' for people with advanced lung cancer who were also receiving standard drug treatments. The goal was to see if this faster approach could help control symptoms like cough or shortness of breath while c…

This small, early-stage study tested whether a 30-week personalized walking program is safe for cancer survivors who were previously hospitalized for COVID-19. The main goal was to see if the exercise caused serious side effects. Researchers worked with just a few participants to…

This study tested a special phone-based therapy program designed to help manage anxiety in older adults with cancer and their primary family caregivers. It compared this therapy to usual care to see if it could better reduce anxiety and improve emotional well-being. The program w…

This study tested whether family therapy sessions could help families communicate and support each other better when a loved one has advanced cancer, both during treatment and after death. Researchers compared standard care to 6 or 10 therapy sessions to see which approach best p…

This study tested different ways to give pain-blocking injections before double mastectomy with reconstruction surgery. Researchers wanted to see which injection method best reduced patients' need for opioid pain medication after surgery. The trial involved over 1,500 women and c…

This study tested whether a new support program could better help the family and friends caring for cancer patients. It involved 150 caregivers and checked if screening them for stress and connecting them to helpful resources reduced their unmet needs over three months. The goal …

This study aimed to understand how many people develop leg swelling (lymphedema) after lymph node surgery for early-stage cervical or vulvar cancer. Researchers surveyed 111 patients who had this surgery between 2006 and 2022 to identify who might be at higher risk. The study onl…

This study aimed to understand how people with a close family member who had melanoma make decisions about sun protection. Researchers interviewed 94 participants about their sunscreen use, shade-seeking, hat wearing, and protective clothing choices. The goal was to learn what in…

This study checked if a low-dose vaginal estrogen tablet (Vagifem) is safe for breast cancer survivors taking aromatase inhibitor medications. Researchers measured whether estrogen from the vaginal tablet gets absorbed into the bloodstream, which could potentially affect cancer r…

This study aimed to improve our ability to predict which people with many moles are most likely to develop melanoma skin cancer. Researchers examined 73 adults with a high number of moles to identify specific mole patterns linked to higher melanoma risk. The goal was to use this …

This study aimed to understand why certain breast cancer drugs eventually stop working for patients. Researchers analyzed tumor samples from people whose cancer progressed despite treatment with targeted therapies or hormone-blocking drugs. By studying these samples, they hoped t…

This study tested whether a program using trained community health workers could help Chinese drivers in New York City who smoke get lung cancer screening and quit-smoking advice. Researchers compared this personal help to just giving people written information. The goal was to s…

This study created a worldwide registry to collect information from people diagnosed with fibrolamellar carcinoma, a rare type of liver cancer. The registry gathered medical history and treatment information from 12 participants to help researchers better understand this disease.…

This study tested whether a new type of camera system could safely and accurately measure blood flow and oxygen levels in human skin. Researchers enrolled 8 healthy volunteers to see how well the camera worked on their arms. The goal was to gather information to see if this techn…

This study asked patients and their caregivers for feedback on self-help manuals designed to teach coping skills after a stem cell transplant. The goal was to understand their experiences and suggestions to improve the guides for future users. Researchers interviewed 41 participa…