Memorial Sloan Kettering Cancer Center

This study tests a two-pronged chemotherapy approach for people with intrahepatic cholangiocarcinoma (a type of bile duct cancer) that cannot be removed by surgery. Participants receive chemotherapy directly to the liver through a surgically placed pump, plus standard chemotherap…

This study looks at whether a ketogenic diet—a very low-carbohydrate diet that forces the body to burn fat for energy—is safe and tolerable for overweight or obese women with newly diagnosed endometrial cancer before they have surgery. Nineteen participants will either follow the…

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This study tested a new way to treat basal cell carcinoma, a common skin cancer. Instead of surgery, doctors used a jet-injection device to deliver a drug called ALA into the tumor, then activated it with red light. The trial included 16 adults with small, low-risk BCCs and aimed…

This study tests whether a combination of three drugs—cisplatin, nivolumab, and temozolomide—can shrink tumors in people with advanced colorectal cancer that has not responded to other treatments. The cancer must be a specific type called MMR-proficient. The trial involves 18 par…

This study tested a combination of brentuximab vedotin and AVD chemotherapy in 118 adults with newly diagnosed, early-stage Hodgkin lymphoma that is considered unfavorable. The goal was to see if this treatment could cure more patients while reducing long-term side effects, espec…

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This phase I trial tested a new type of radiation therapy for low- and intermediate-risk prostate cancer that delivers a higher dose each day, completing treatment in just 5 sessions over 2 weeks instead of the usual 45-48. The study enrolled 120 participants to check the safety …

This study tested whether adding a radioactive drug (radium-223) to standard targeted radiation (SBRT) can delay cancer progression in men whose prostate cancer has returned in a few bone spots but hasn't yet become hormone-resistant. Twelve men participated, receiving either the…

This phase II trial tested whether combining two drugs, pembrolizumab and olaparib, could help people with persistent or recurrent endometrial cancer or carcinosarcoma. The study enrolled 26 participants and looked at how many responded to treatment and what side effects occurred…

This early-stage trial tested the safety of a drug called duvelisib when given with either romidepsin or bortezomib for adults with T-cell lymphoma that returned or didn't respond to prior treatment. The study involved 114 participants and aimed to find the highest safe dose. Thi…

This phase 2 study tested whether the drug romiplostim can prevent severe low platelet counts caused by chemotherapy in people with lymphoma. Eleven adult patients received weekly injections of romiplostim during their 21-day chemo cycles. The goal was to see if it could reduce t…

This study tested whether giving three hormone-blocking drugs along with high-dose, precisely targeted radiation could stop very high-risk prostate cancer from coming back. Sixty-four men with aggressive prostate cancer received the treatment. The main goal was to see how many me…

This study tested proton therapy in 87 adults whose head and neck cancer came back after prior radiation. The goal was to see if this precise type of radiation can control the tumor while limiting side effects. Participants had cancer that could not be removed by surgery or chose…

This phase 2 study tested a combination of two drugs, fulvestrant and abemaciclib, in 28 patients with a specific type of uterine cancer that is sensitive to hormones. The goal was to see if the drugs could shrink tumors or stop them from growing. Researchers also tracked side ef…

This study tested the safety of combining different doses of external radiation therapy with the chemotherapy drug gemcitabine in 19 bladder cancer patients. The goal was to find the highest safe dose of radiation that can be given alongside chemo. Participants had early-stage bl…

This study tested a new way to treat multiple myeloma by starting with just two drugs (bortezomib and dexamethasone) and adding a third (lenalidomide) only if the disease wasn't well controlled. The goal was to see if this step-by-step approach could achieve the same good results…

This study compares two radiation approaches for leptomeningeal metastases, a condition where cancer spreads to the fluid and lining around the brain and spinal cord. One group receives proton craniospinal irradiation, which targets the entire brain and spine, while the other get…

This study tested the safety and effectiveness of combining two targeted drugs, copanlisib and ibrutinib, in 18 adults with primary CNS lymphoma that had returned or not responded to prior therapy. The goal was to find the best dose and see how many patients' tumors shrank. This …

This pilot study tested a drug called BGJ398 in 4 people with a type of bladder cancer that stays in the bladder lining but keeps coming back after standard treatment. The drug targets tumors with a specific genetic change (FGFR3 mutation or fusion). The main goal was to see if t…

This study tested whether a Medtronic pump and Codman catheter can safely deliver chemotherapy directly to the liver in 35 people with colorectal cancer or bile duct cancer that spread to the liver. The main goal was to check safety, including liver side effects and need for sten…

This study tested the drug ibrutinib (Imbruvica) in 93 adults with a rare type of brain lymphoma (PCNSL or SCNSL), either newly diagnosed or that had come back. The goal was to find the best dose and see if adding it to standard chemotherapy improves how many patients achieve com…

This study tested whether a procedure called local ablative therapy (LAT) can help control metastatic non-small cell lung cancer (NSCLC) when a blood test shows signs of remaining cancer (minimal residual disease, or MRD). 37 patients with stage IV NSCLC received LAT to all visib…

This early-phase trial tested a combination of three drugs—ibrutinib, rituximab, and lenalidomide—in 25 patients with central nervous system lymphoma that had returned or not responded to prior treatment. The main goal was to find the safest dose of ibrutinib when given with the …

This study tested whether the drug nivolumab can safely prevent primary central nervous system lymphoma (PCNSL) from coming back. It included 14 people who still had signs of tumor DNA in their spinal fluid after finishing their first chemotherapy. The goal was to see if nivoluma…

This study looked at whether switching from the immunotherapy durvalumab to the targeted drug sotorasib can better control locally advanced non-small cell lung cancer in patients with a KRAS G12C mutation and signs of remaining cancer (minimal residual disease). Ten participants …

This early-phase study tested a drug called enasidenib in 4 people with a rare blood condition (CCUS) and a specific gene change (IDH2). The goal was to see if the drug could safely improve low blood cell counts. The study is complete, but results are not yet reported.

This study tested a new device that delivers targeted radiation to early-stage basal and squamous cell skin cancers. Thirty-six people aged 60 and older received treatment, and researchers tracked how well the cancer was controlled, cosmetic results, and quality of life. The goal…

This early-phase study tested the safety of combining two targeted drugs, dacomitinib and osimertinib, in 22 people with a specific type of advanced lung cancer (EGFR mutant). Participants had not received similar targeted therapy before. The goal was to find the safest dose and …

This phase 2 trial tested two drugs, amivantamab and lazertinib, in 43 adults with a specific type of lung cancer (EGFR-mutant) that had spread to the brain and worsened after previous treatments. The goal was to see if the combination could shrink or control brain tumors. Both d…

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 64 people with recurrent or metastatic salivary gland cancer that could not be removed by surgery or treated with radiation. The goal was to see how well the combination shrank tumors and what side effects oc…

This study looked at a combination of two drugs, talazoparib and temozolomide, in 16 men with advanced prostate cancer that had spread and stopped responding to hormone therapy. The goal was to find the safest dose and see if the drugs could shrink tumors. The study was completed…

This pilot study tested whether adding the immunotherapy drugs nivolumab (with or without ipilimumab) to standard chemotherapy could be safe for people with advanced high-grade serous ovarian, fallopian tube, or primary peritoneal cancer. 27 participants received the drug combina…

This early-stage study tested the safety of combining the drug rucaparib with standard radiation therapy in 31 women with triple-negative breast cancer who still had cancer cells after chemotherapy and surgery. The goal was to find a safe dose and see if the combination could be …

This study tested whether adding the immunotherapy drug pembrolizumab to standard radiation or ablation could help people with metastatic colorectal cancer. The idea is that the combination might trigger a stronger immune response that also attacks tumors not directly treated. Th…

This study tested a combination of three drugs—carfilzomib, lenalidomide, and dexamethasone—in 29 people newly diagnosed with multiple myeloma. The goal was to find the safest high dose of carfilzomib and see how well it clears cancer cells from the body. Researchers measured sid…

This study looked at ways to help taxi drivers lower their blood pressure and improve their health. Researchers added extra support like health coaching and follow-up calls to regular health fairs. 166 male drivers with high blood pressure took part. The goal was to find the best…

This study looked at nearly 1,000 adults having pancreatic surgery to see which antibiotic, cefoxitin or piperacillin-tazobactam, works better at preventing wound infections within 30 days after the operation. Participants received one of the two antibiotics before surgery. The g…

This study tested whether a targeted drug called brentuximab vedotin (SGN-35) could replace the standard ICE chemotherapy before a stem cell transplant in 66 people with relapsed or refractory Hodgkin lymphoma. The drug targets cancer cells and has fewer side effects than ICE. Pa…

This study tested a drug called vemurafenib (Zelboraf) in 36 people with hairy cell leukemia that had returned or not responded to standard therapy. The goal was to see how well the drug could clear leukemia from the blood and what side effects it caused. Vemurafenib works by blo…

This study tested whether adding the targeted drug panitumumab to standard chemotherapy (given through the liver artery and a vein) could help keep colorectal cancer from returning after liver metastases were surgically removed. It involved 75 adults with a specific gene type (wi…

This study tested whether giving the drug romidepsin after a high-dose chemotherapy and stem cell transplant could help people with T-cell non-Hodgkin lymphoma stay in remission longer. Forty-seven patients participated. The goal was to see if this maintenance therapy improves pr…

This study tested whether adding an immunotherapy drug (Hu3F8) plus GM-CSF to standard treatment could help children with high-risk neuroblastoma stay in remission longer. Fifty-nine children who had already achieved remission after initial therapy received the combination along …

This early-phase trial tested a reduced dose of radiation in 78 children with high-risk neuroblastoma. The goal was to see if a lower dose could still control the tumor while causing fewer long-term side effects. Researchers monitored local control rates and side effects over tim…

This study tested two ways to treat multiple myeloma that has come back or stopped responding to treatment. All 23 participants first received a combination of clarithromycin, pomalidomide, and dexamethasone. Then, half got a stem cell transplant followed by pomalidomide, while t…

This phase II trial tested the oral drug regorafenib in 38 patients with progressive, recurrent, or metastatic adenoid cystic carcinoma, a rare cancer of the salivary glands. Regorafenib works by blocking signals that help cancer cells grow and by cutting off blood supply to tumo…

This early-phase trial tested two drugs, vemurafenib and copanlisib, in 8 people with advanced BRAF-mutant thyroid cancers that had stopped responding to radioiodine therapy. The goal was to see if the combination could make tumors sensitive to radioiodine again and to find the s…

This study tested a new type of PET scan using a radioactive tracer called 89Zr-DFO-huJ591 to find prostate cancer that has spread to other parts of the body. 77 men with metastatic prostate cancer received the experimental scan, and some also had standard scans and biopsies for …

This early study tested a new imaging technique that combines a special tracer ([18F]PARPi) with PET and MRI scans to get clearer pictures of brain tumors. Five adults with new or suspected returning brain tumors took part. The goal was to see how well the tracer highlights tumor…

This study tested whether a special camera (hyperspectral imaging system) can measure blood flow and oxygen levels in the skin of healthy people. Eight volunteers aged 18 to 45 had their skin scanned to see if the camera could detect changes when blood vessels tighten or relax. T…

This study looked at whether a device called Nevisense, which measures the electrical properties of moles, can help doctors better assess suspicious moles during routine skin checks. Forty adults with many moles (at least 100) and several large moles took part. The goal is to imp…

This study tested whether placing a special mesh during bladder removal surgery (radical cystectomy) could lower the chance of developing a parastomal hernia, a common complication. 178 patients having bladder removal for cancer took part. The researchers compared those who got t…

This phase 3 trial compared colonoscopy with annual fecal occult blood tests for colorectal cancer screening in nearly 5,000 healthy adults aged 50-69. The goal was to see which method finds more early tumors and has a better balance of benefits and harms. Participants were rando…

This study tested whether the drug benralizumab can safely reduce skin rashes caused by cancer treatments like checkpoint inhibitors. The goal was to lower the number of high-grade rashes to milder ones, which could improve quality of life and help patients stay on their cancer t…

This study tested whether family-focused grief therapy (FFGT) helps families cope when a member has advanced cancer. 700 families were randomly assigned to standard care, 6 therapy sessions, or 10 sessions. The goal was to prevent depression and improve communication during palli…

This study tested three different nerve block methods to manage pain after a double mastectomy with immediate reconstruction. Over 1,500 women received either a paravertebral block, a serratus+PECS-1 block, or a combination. The goal was to see which approach reduces the need for…

This study tested the safety of a special radiation schedule called Quad Shot for people with stage IV non-small cell lung cancer who are also receiving chemotherapy or immunotherapy. The Quad Shot delivers radiation in just 2 days per cycle, up to 3 cycles, to make it easier to …

This study tested a radiation method called multi-beam IMRT in 100 women with breast cancer who had implant reconstructions after mastectomy. The goal was to see if using 8-12 small radiation beams instead of the standard 2-5 could reduce implant failure and side effects. Results…

This study looked at two ways to help older patients (65+) with head and neck cancer manage side effects during radiation and chemotherapy. One approach involved a geriatric specialist working with the cancer team, and the other provided extra supportive care guided by a geriatri…

This study tested whether a gel made from birch bark extract (Oleogel-S10) can help heal skin burns caused by radiation therapy in breast cancer patients. 18 women with moderate to severe radiation dermatitis used the gel along with a standard steroid cream. The goal was to see i…

This study tested a 30-week walking program for cancer survivors who had been hospitalized with COVID-19. The goal was to see if the exercise was safe and caused few side effects. Only 3 people took part, so the results are very early and not conclusive.

This study tested a telephone-based therapy called Managing Anxiety from Cancer (MAC) for older adults (65+) with cancer and their caregivers. The therapy includes seven sessions covering relaxation, communication, and problem-solving skills. The goal was to see if it reduces anx…

This study tested whether colesevelam, a drug used for high cholesterol, can safely reduce diarrhea in people with multiple myeloma who take lenalidomide. 25 participants received colesevelam for 4 weeks. The goal was to see if diarrhea improved to a mild level or better. The stu…

This early-phase trial tested a dye called Illuminare-1 that makes nerves glow during prostate cancer surgery. The goal was to find a safe dose that helps surgeons avoid damaging nerves, which can cause side effects like incontinence. The study involved 41 men undergoing standard…

This study tests whether a biopsy technique called transbronchial cryobiopsy is safer than the standard method for diagnosing lung cancer. About 100 adults with known or suspected lung cancer will undergo the procedure under general anesthesia. Researchers will track complication…

This study looks at why some men feel anxious about giving themselves penile injections for erectile dysfunction after pelvic surgery. Researchers will ask 126 men to fill out questionnaires before, during, and after injection training. The goal is to better understand and measur…

This study looked at 133 Hodgkin lymphoma survivors who had chest radiation at least 5 years ago. Researchers compared two heart tests—a stress echocardiogram and a cardiac MRI—to see which one finds heart damage earlier. The goal is to improve long-term heart monitoring for thes…

This completed study looked at why certain breast cancer drugs stop working over time. Researchers collected tumor samples from 269 patients to study genetic changes that might cause resistance. The goal was to better understand these mechanisms so that future treatments can be i…

This completed study from Memorial Sloan Kettering Cancer Center looked at how people with a close family member who had melanoma make decisions about sun protection. Researchers interviewed 94 participants and used an electronic diary to track daily behaviors like sunscreen use …

This study looked at whether it's possible to give ovarian cancer patients a special nutrition shake for seven days before their surgery. 23 patients took part to see if they would stick with the program. The goal was just to see if the program was doable, not to measure health b…

This study tested if a special dye (ICG) can help surgeons find the first lymph nodes that ovarian cancer might spread to. 48 women having ovary surgery took part. The goal was to see if the dye works well for this purpose, which could help doctors better understand and stage the…

This study looked at whether a low-dose vaginal estrogen tablet (Vagifem) is safe for women who have had breast cancer and are taking aromatase inhibitors. 31 postmenopausal women with a history of breast cancer used the tablet for vaginal dryness. Researchers measured their bloo…

This study looked at 73 people with many moles to see if certain mole features can help predict who is most likely to develop melanoma. Participants gave saliva samples and had their moles photographed and analyzed. The goal is to improve risk assessment and make melanoma screeni…

This study looked at 111 people who had surgery for early-stage cervical or vulvar cancer to find out how many develop lower leg swelling (lymphedema). Researchers used a questionnaire to gather information, not to test any new treatment. The goal is to better identify who is at …

This study tested whether a Community Health Worker (CHW) program could help at-risk Chinese community members in New York City get lung cancer screening. Researchers enrolled 99 participants, including Chinese immigrant livery drivers aged 45-80 who smoke or used to smoke. The C…

This study looked at whether a program that screens cancer caregivers for distress and offers them support (called S+C) works better than usual care. About 150 caregivers of cancer patients took part. The goal was to see if the program helps reduce caregivers' unmet needs and imp…

This study gathered information from 12 people with fibrolamellar cancer (FLC) around the world. Participants shared their medical history and regular care details through an online registry. The goal was to create a database for future research, not to provide treatment.

This study tested whether patients and caregivers find 'Coping Together' manuals helpful after a stem cell transplant. 41 participants shared their thoughts on the manuals during the first 100 days after transplant. The goal was to improve these self-directed coping guides for fu…

This study tested a special radioactive substance called 124-Iodine to see how much radiation each thyroid cancer spot in the body receives. The goal was to help doctors decide the right dose of standard treatment (131-Iodine) and avoid giving unnecessary radiation to patients wh…

This study tested whether small devices called Calypso beacons, placed near lung tumors, can help doctors track the tumor's position during radiation while the patient holds their breath. 48 adults with lung cancer took part. The goal was to see if this approach is feasible and t…