New cocktail aims to knock out tough prostate cancer

NCT ID NCT02772588

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving three hormone-blocking drugs along with high-dose, precisely targeted radiation could stop very high-risk prostate cancer from coming back. Sixty-four men with aggressive prostate cancer received the treatment. The main goal was to see how many men had a rise in their PSA levels, which would signal the cancer had returned.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: apalutamide, abiraterone, leuprolide, and high-dose precision radiation
What this could lead to: If successful, this combination could offer a more effective way to prevent prostate cancer from coming back in very high-risk patients.
What could go wrong: This is a small, single-arm phase 2 study with no comparison group, so results may not apply broadly. Hormone therapy can cause side effects like hot flashes and fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

Locations

John Hopkins Medical Center

Baltimore, Maryland, 21287, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Rockville

Rockville Centre, New York, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
University of Michigan Health System

Ann Arbor, Michigan, 48109, United States
Weill Cornell Medical Center

New York, New York, 10065, United States

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