Immunotherapy combo shows promise for rare salivary cancer

NCT ID NCT03172624

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested two immunotherapy drugs, nivolumab and ipilimumab, in 64 people with recurrent or metastatic salivary gland cancer that could not be removed by surgery or treated with radiation. The goal was to see how well the combination shrank tumors and what side effects occurred. The trial has been completed, and results will help determine if this approach is worth further study.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: nivolumab and ipilimumab (immunotherapy drugs)
What this could lead to: If it works, this could offer a new treatment option for people with advanced salivary gland cancer that has spread or come back.
What could go wrong: This is a small, early-phase trial (phase 2) with only 64 people. The drugs may cause serious side effects, and the response rate might be low.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoid cystic carcinoma salivary gland cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SALIVARY GLAND CANCER

Contacts and locations

Locations

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Rockville Centre

Rockville Centre, New York, 11570, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

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