New drug combo shows promise for lung cancer brain metastases

NCT ID NCT04965090

Completed Disease control Sponsor: Memorial Sloan Kettering Cancer Center Source: ClinicalTrials.gov ↗

First seen Jan 06, 2026 · Last updated May 12, 2026 · Updated 17 times

Summary

This study tested two drugs, amivantamab and lazertinib, in 43 adults with a specific type of lung cancer (EGFR-mutant) that had spread to the brain or spinal cord lining and was getting worse despite prior treatments. The goal was to see if the combination could shrink or control these brain tumors. The drugs target cancer cells with the EGFR mutation to slow their growth.

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Contacts and locations

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Locations

Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States

Conditions

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METASTATIC NON-SMALL CELL LUNG CANCER RECURRENT NON-SMALL CELL LUNG CANCER