New drug combo shows promise for rare brain cancer

NCT ID NCT02315326

First seen Feb 02, 2026 · Last updated May 08, 2026 · Updated 12 times

Summary

This study tested the drug ibrutinib, alone or with chemotherapy, in 93 adults with a rare type of brain lymphoma (PCNSL or SCNSL). The goal was to find the safest dose and see if it improves how well the cancer responds to treatment. The trial combined ibrutinib with standard chemotherapy to try to control the disease better.

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Contacts and locations

Locations

  • Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

    Basking Ridge, New Jersey, United States

  • Memorial Sloan Kettering Bergen (Limited Protocol Activities)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering Cancer Center

    New York, New York, 10065, United States

  • Memorial Sloan Kettering Commack (Limited Protocol Activities)

    Commack, New York, 11725, United States

  • Memorial Sloan Kettering Monmouth (Limited Protocol Activities)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering Nassau (Limited Protocol Activities)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering Westchester (Limited Protocol Activities)

    Harrison, New York, 10604, United States

Conditions

Explore the condition pages connected to this study.